Development of therapeutic drugs for fibrodysplasia ossificans progressiva by drug repositioning strategies

• Project/Area Number: 15K15548
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Nagoya University
• Principal Investigator: Kitoh Hiroshi 名古屋大学, 医学系研究科, 准教授 (40291174)
• Co-Investigator(Kenkyū-buntansha): 杉浦 洋 名古屋大学, 医学部附属病院, 医員 (40750477) ; 松下 雅樹 名古屋大学, 医学部附属病院, 病院助教 (60721115)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 進行性骨化性線維異形成症 / ドラッグ・リポジショニング / 異所性骨化 / Id1 / ALK2 / ドラッグスクリーニング / 薬効スクリーニング

Outline of Final Research Achievements

Fibrodysplasia ossificans progressiva (FOP) is a severely disabling heritable disorder of connective tissue characterized by progressive heterotopic ossification in various extraskeletal sites. FOP is caused by a gain-of-function mutation in ALK2, which causes up regulation of a transcriptional factor, Id1. We screened FDA-approval drugs for suppression of the Id1 promoter activated by the mutant ALK2 in C2C12 myogenic cells. We found that azelastine HCl (anti-histamine), Fluvastatin sodium salt (ant-hyperlipidemia), and Trimipramine maleate salt (anti-depressant) suppressed the Id1 promoter activity in a dose-dependent manner. These drugs also downregulated the expressions of the Id1-target osteoblastic genes such as alkaline phosphatase and osteocalcin.

Research Products

• [Journal Article] Activated FGFR3 prevents subchondral bone sclerosis during the development of osteoarthritis in transgenic mice with achondroplasia. (2018)
  • Author(s): 6.Okura T, Matsushita M, Mishima K, Esaki R, Seki T, Ishiguro N, Kitoh H.
  • Journal Title: J Orthop Res Volume: 36(1) Issue: 1 Pages: 300-308
  • DOI: 10.1002/jor.23608
  • Peer Reviewed / Open Access
• [Journal Article] Chronic lateral epiphyseal separation of the proximal tibia causes late-onset tibia vara. (2018)
  • Author(s): Hasegawa S, Kitoh H, Matsushita M, Mishima K, Kadono I, Sugiura H, Kitamura A, Ishiguro N
  • Journal Title: J Pediatr Orthop B. Volume: 27 Issue: 1 Pages: 31-34
  • DOI: 10.1097/bpb.0000000000000430
  • Peer Reviewed / Open Access
• [Journal Article] Maternal administration of meclozine for the treatment of foramen magnum stenosis in transgenic mice with achondroplasia (2017)
  • Author(s): Matsushita M, Mishima K, Esaki R, Ishiguro N, Ohno K, Kitoh H
  • Journal Title: J Neurosurg Pediatr Volume: 19 Issue: 1 Pages: 91-95
  • DOI: 10.3171/2016.7.peds16199
  • Peer Reviewed / Open Access
• [Journal Article] Is the timing of surgery associated with avascular necrosis after unstable slipped capital femoral epiphysis? A multicenter study. (2017)
  • Author(s): Kohno Y, Nakashima Y, Kitano T, Irie T, Kita A, Nakamura T, Endo H, Fujii Y, Kuroda T, Mitani S, Kitoh H, Matsushita M, Hattori T, Iwata K, Iwamoto Y.
  • Journal Title: J Orthop Sci. Volume: 22 Issue: 1 Pages: 112-115
  • DOI: 10.1016/j.jos.2016.08.012
  • Peer Reviewed / Open Access
• [Journal Article] Percutaneous pinning after prolonged skeletal traction with the hip in a flexed position for unstable slipped capital femoral epiphysis: A case series of 11 patients. (2017)
  • Author(s): Matsushita M, Mishima K, Iwata K, Hattori T, Ishiguro N, Kitoh H.
  • Journal Title: Medicine (Baltimore). Volume: 96 Issue: 19 Pages: e6662-e6662
  • DOI: 10.1097/md.0000000000006662
  • Peer Reviewed / Open Access
• [Journal Article] Activated FGFR3 promotes bone formation via accelerating endochondral ossification in mouse model of distraction osteogenesis (2017)
  • Author(s): Osawa Yusuke、Matsushita Masaki、Hasegawa Sachi、Esaki Ryusaku、Fujio Masahito、Ohkawara Bisei、Ishiguro Naoki、Ohno Kinji、Kitoh Hiroshi
  • Journal Title: Bone Volume: 105 Pages: 42-49
  • DOI: 10.1016/j.bone.2017.05.016
  • Peer Reviewed / Open Access
• [Journal Article] Clinical dosage of meclozine promotes longitudinal bone growth, bone volume, and trabecular bone quality in transgenic mice with achondroplasia. (2017)
  • Author(s): Matsushita M, Esaki R, Mishima K, Ishiguro N, Ohno K, Kitoh H.
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 7371-7371
  • DOI: 10.1038/s41598-017-07044-8
  • Peer Reviewed / Open Access
• [Journal Article] Early radiographic risk factors for rigid relapse in idiopathic clubfoot treated with the Ponseti method. (2017)
  • Author(s): Mishima K, Kitoh H, Matsushita M, Sugiura H, Hasegawa S, Kitamura A, Nishida Y, Ishiguro N.
  • Journal Title: Foot Ankle Surg. Volume: ー Issue: 6 Pages: 30126-1
  • DOI: 10.1016/j.fas.2017.06.003
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal study of the activities of daily living and quality of life in Japanese patients with fibrodysplasia ossificans progressiva. (2017)
  • Author(s): 9.Nakahara Y, Kitoh H, Nakashima Y, Toguchida J, Haga N.
  • Journal Title: Disabil Rehabil Volume: 16 Issue: 6 Pages: 1-6
  • DOI: 10.1080/09638288.2017.1405083
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of novel Runx2 mutation with alanine tract expansion from Japanese cleidocranial dysplasia patient (2016)
  • Author(s): Shibata A, Machida J, Yamaguchi S, Kimura M, Tatematsu T, Miyachi H, Matsushita M, Kitoh H, Ishiguro N, Nakayama A, Higashi Y, Shimozato K, Tokita Y
  • Journal Title: Mutagenesis Volume: 31 Pages: 61-67
  • DOI: 10.1093/mutage/gev057
  • Peer Reviewed
• [Journal Article] Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters. (2016)
  • Author(s): Hasegawa S, Kitoh H, Ohkawara B, Mishima K, Matsushita M, Masuda A, Ishiguro N, Ohno K
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 470(2) Issue: 2 Pages: 356-61
  • DOI: 10.1016/j.bbrc.2016.01.044
  • Peer Reviewed / Open Access
• [Journal Article] Hyperpigmentation over the metacarpophalangeal joints and the malleoli in a case of hyaline fibromatosis syndrome with ANTXR2 mutations. (2016)
  • Author(s): Sugiura K, Ohno A, Kono M, Kitoh H, Itomi K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol. Volume: - Issue: 10 Pages: 44-46
  • DOI: 10.1111/jdv.13290
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical Results and Complications of Lower Limb Lengthening for Fibular Hemimelia: A Report of Eight Cases. (2016)
  • Author(s): Mishima K, Kitoh H, Iwata K, Matsushita M, Nishida Y, Hattori T, Ishiguro N.
  • Journal Title: Medicine (Baltimore) Volume: 95 Issue: 21 Pages: e3787-e3787
  • DOI: 10.1097/md.0000000000003787
  • Peer Reviewed / Open Access
• [Journal Article] Characteristic calcaneal ossification: an additional early radiographic finding in infants with fibrodysplasia ossificans progressiva (2016)
  • Author(s): Hasegawa S, Victoria T, Kayserili H, Zackai E, Nishimura G, Haga N, Nakashima Y, Miyazaki O, Kitoh H
  • Journal Title: Ped Radiol Volume: 46 Issue: 11 Pages: 1568-1572
  • DOI: 10.1007/s00247-016-3662-3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A rare case of femoral hypoplasia (proximal focal femoral deficiency) with overlapping phenotype of mullerian duct syndrome (Mayer-Rokitansky-Hauser syndrome) (2016)
  • Author(s): Melovitz-Vasan C, Kitoh H, Vasan N
  • Journal Title: Int J Anat Res Volume: 4 Pages: 3312-3316
  • Peer Reviewed
• [Journal Article] Low bone mineral density in achondroplasia and hypochondroplasia (2015)
  • Author(s): Matsushita M, Kitoh H, Mishima K, Kadono I, Sugiura H, Hasegawa S, Nishida Y, Ishiguro N
  • Journal Title: Pediatr Int. Volume: 印刷中 Issue: 8 Pages: 705-708
  • DOI: 10.1111/ped.12890
  • Peer Reviewed
• [Journal Article] A glutamine repeat variant of the RUNX2 gene causes cleidocranial dysplasia (2015)
  • Author(s): Matsushita M, Kitoh H, Subasioglu A, Colak FK, Dundar M, Mishima K, Nishida Y, Ishiguro N
  • Journal Title: Mol Syndromol Volume: 6 Issue: 1 Pages: 50-53
  • DOI: 10.1159/000370337
  • Peer Reviewed
• [Journal Article] C-type natriuretic peptide (CNP) plasma levels are elevated in subjects with achondroplasia, hypochondroplasia, and thanatophoric dysplasia (2015)
  • Author(s): Olney RC, Prickett TCR, Espiner EA, Mackenzie WG, Duker A, Ditro C, Zabel B, Hasegawa T, Kitoh H, Aylsworth AS, Bober MB
  • Journal Title: J Clin Endocrinol Metab Volume: 100 Issue: 2 Pages: 355-359
  • DOI: 10.1210/jc.2014-2814
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Congenital myasthenic syndrome in Japan: ethnically unique mutations in muscle nicotinic acetylcholine receptor subunits (2015)
  • Author(s): Azuma Y, Nakata T, Tanaka M, Shen X M, Ito M, Iwata S, Okuno T, Nomura Y, Ando N, Ishigaki K, Ohkawara B, Masuda A, Natsume J, Kojima S, Sokabe M, Ohno K
  • Journal Title: Neuromuscul Disord Volume: 25 Issue: 2 Pages: 60-69
  • DOI: 10.1210/en.2014-1914
  • Peer Reviewed
• [Journal Article] Prediction of clinically significant leg-length discrepancy in congenital disorders (2015)
  • Author(s): Mishima K, Kitoh H, Kadono I, Mastushita M, Sugiura H, Hasegawa S, Kitamura A, Nishida Y, Ishiguro N
  • Journal Title: Orthopedics Volume: 38 Issue: 10 Pages: 919-924
  • DOI: 10.3928/01477447-20151002-60
  • Peer Reviewed / Open Access
• [Journal Article] Lansoprazole upregulates polyubiquitination of TRAF6 and facilitates Runx2-mediated osteoblastogenesis (2015)
  • Author(s): Kenichi Mishima, Hiroshi Kitoh, Bisei Ohkawara, Tatsuya Okuno, Mikako Ito, Akio Masuda, Naoki Ishiguro, Kinji Ohno
  • Journal Title: EBio Medicin Volume: 2 Issue: 12 Pages: 20462061-20462061
  • DOI: 10.1016/j.ebiom.2015.11.024
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Bone formation was promoted in mouse model of distraction osteogenesis with gain-of-function mutations in Fgfr3 (2018)
  • Author(s): Yusuke Osawa, Masaki Matsushita, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno, Hiroshi Kitoh
  • Organizer: Annual meeting of Orthopaedic Research Society
  • Int'l Joint Research
• [Presentation] Transplantation of autologous culture-expanded bone marrow cells and platelet rich plasma for bone regeneration. Comprehensive clinical study of the lower limb lengthening (2017)
  • Author(s): Hiroshi Kitoh, Kenichi Mishima, Masaki Matsushita, Hiroshi Sugiura, Akiko Kitamura, Naoki Ishiguro
  • Organizer: EPOS/POSNA combined annual meeting
  • Int'l Joint Research
• [Presentation] Clinical feasibility of meclozine for improvement of short stature in achondroplasia (2017)
  • Author(s): Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Hiroshi Sugiura, Akiko Kitamura, Naoki Ishiguro
  • Organizer: EPOS/POSNA combined annual meeting
  • Int'l Joint Research
• [Presentation] Long term health-related quality of life in achonroplasia (2017)
  • Author(s): Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Satoshi Yamashita, Hiroshi Sugiura, Akiko Kitamura, Naoki Ishiguro
  • Organizer: EPOS/POSNA combined annual meeting
  • Int'l Joint Research
• [Presentation] Disappearance of soft tissue interposition after gradual reduction using overhead traction in late-presenting DDH. A prospective comparative study on serial MRIs between pre-walking and walking children (2017)
  • Author(s): Hiroshi Kaneko, Tadashi Hattori, Koji Iwata, Masaki Matsushita, Hiroki Furuhashi, Hiroshi Kitoh
  • Organizer: EPOS/POSNA combined annual meeting
  • Int'l Joint Research
• [Presentation] Secondary spherical remodeling from the healed stage to skeletal maturity in Legg-Calve-Perthes Disease treated with Salter innominate osteotomy (2017)
  • Author(s): Hiroshi Kaneko, Hiroshi Kitoh, Masaki Matsushita, Hiroki Furuhashi, Tadashi Hattori
  • Organizer: EPOS/POSNA combined annual meeting
  • Int'l Joint Research
• [Presentation] Salter innominate osteotomy for DDH in childhood does not predispose to anterior over-coverage and posterior under-coverage in adulthood (2017)
  • Author(s): Hiroki Furuhashi, Hiroshi Kaneko, Koji Iwata, Tadashi Hattori, Hiroshi Kitoh
  • Organizer: EPOS/POSNA combined annual meeting
  • Int'l Joint Research
• [Presentation] Transplantation of autologous culture-expanded bone marrow cells and platelet rich plasma during lower limb lengthening (2017)
  • Author(s): Hiroshi Kitoh, Kenichi Mishima, Masaki Matsushita, Naoki Ishiguro
  • Organizer: The 27th Korean-Japanese Combined Orthopaedic Symposium
  • Int'l Joint Research / Invited
• [Presentation] Clinically feasible dose of meclozine improves bone growth, bone volume, and bone quality in mouse model with achondroplasia (2017)
  • Author(s): Masaki Matsushita, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno, Hiroshi Kitoh
  • Organizer: The 27th Korean-Japanese Combined Orthopaedic Symposium
  • Int'l Joint Research
• [Presentation] Activated FGFR3 prevents subchondral bone sclerosis during the development of osteoarthritis in transgenic mice with achondroplasia (2017)
  • Author(s): Toshiaki Okura, Masaki Matsushita, Kenichi Mishima, Ryusaku Esaki, Taisuke Seki, Naoki Ishiguro, Hiroshi Kitoh
  • Organizer: The 27th Korean-Japanese Combined Orthopaedic Symposium
  • Int'l Joint Research
• [Presentation] Activated FGFR3 promotes bone formation via accelerating endochondral ossification in mouse model of distraction osteogenesis (2017)
  • Author(s): Yusuke Osawa, Masaki Matsushita, Naoki Ishiguro, Kinji Ohno, Hiroshi Kitoh
  • Organizer: The 27th Korean-Japanese Combined Orthopaedic Symposium
  • Int'l Joint Research
• [Presentation] Oral administration of meclozine for the treatment of short stature in achondroplasia (2017)
  • Author(s): Hiroshi Kitoh, Masaki Matsushita, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno
  • Organizer: The 13th International Skeletal Dysplasia Meeting
  • Int'l Joint Research
• [Presentation] Treatment of deformities in lower extremity by a multi-axial external fixation system (2017)
  • Author(s): Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Naoki Ishiguro
  • Organizer: The 61st Korean Orthopaedic Association
  • Int'l Joint Research
• [Presentation] 培養骨髄細胞と多血小板血漿の移植を併用した下肢骨延長術 (2017)
  • Author(s): 鬼頭浩史、石黒直樹
  • Organizer: 第11回骨軟骨フロンティア
  • Int'l Joint Research / Invited
• [Presentation] 小児整形外科領域における骨系統疾患 (2017)
  • Author(s): 鬼頭浩史
  • Organizer: 第10回胎児骨系統疾患フォーラム学術講演会
  • Int'l Joint Research / Invited
• [Presentation] 骨髄間葉系幹細胞とPRPを用いた骨延長術 (2017)
  • Author(s): 鬼頭浩史、三島健一、松下雅樹、石黒直樹
  • Organizer: 第2回JAPSAM幹細胞研究会
  • Int'l Joint Research / Invited
• [Presentation] Treatment strategies for short stature in achondroplasia (2016)
  • Author(s): Hiroshi Kitoh
  • Organizer: 第50回日本小児内分泌学会・第9回アジア太平洋小児内分泌学会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2016-11-16
  • Int'l Joint Research / Invited
• [Presentation] FGFR3-targetted therapy for short stature in achondroplasia (2016)
  • Author(s): Hiroshi Kitoh, Masaki Matsushita, Kenichi Mishima, Naoki Ishiguro
  • Organizer: 60th Korean Orthopaedic Association
  • Place of Presentation: Incheon （Korea）
  • Year and Date: 2016-10-19
  • Int'l Joint Research / Invited
• [Presentation] Transplantation of culture-expanded bone marrow cells and platelet rich plasma in limb lengthening Clinical trial and further improvement (2016)
  • Author(s): Hiroshi Kitoh, Kenichi Mishima, Masaki Matsushita, Naoki Ishiguro
  • Organizer: 60th Korean Orthopaedic Association
  • Place of Presentation: Incheon （Korea）
  • Year and Date: 2016-10-19
  • Int'l Joint Research / Invited
• [Presentation] Clinical feasibility of oral administration of meclozine for the treatment of short stature in achondroplasia (2016)
  • Author(s): Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno
  • Organizer: Annual meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Atlanta （ＵＳＡ）
  • Year and Date: 2016-09-16
  • Int'l Joint Research
• [Presentation] Early radiographic parameters predictive of surgery-required relapse in idiopathic clubfoot treated using the Ponseti method (2016)
  • Author(s): Kenichi Mishima, Hiroshi Kitoh, Masaki Matsushita, Hiroshi Sugiura, Sachi Hasegawa, Yoshihiro Nishida, Naoki Ishiguro
  • Organizer: 37th SICOT Orthopaedic World Congress
  • Place of Presentation: Rome （Italy）
  • Year and Date: 2016-09-08
  • Int'l Joint Research
• [Presentation] Clinically attainable concentration of meclozine has a potent effect on promoting bone growth in achondroplasia (2016)
  • Author(s): Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno
  • Organizer: The annual scientific meeting of the endocrine society of Australia, the Society for Reproductive Biology and the Australia and New Zealand Bone and Mineral Society
  • Place of Presentation: Gold Coast （Australia）
  • Year and Date: 2016-08-21
  • Int'l Joint Research
• [Presentation] 軟骨無形成症の低身長に対する治療 (2016)
  • Author(s): 鬼頭浩史、三島健一、松下雅樹
  • Organizer: 第34回日本骨代謝学会・第3回アジア太平洋骨代謝学会
  • Place of Presentation: 大阪国際会議場（大阪市北区）
  • Year and Date: 2016-07-20
  • Int'l Joint Research / Invited
• [Presentation] ランソプラゾールによる骨芽細胞・破骨細胞分化促進効果と分子作用機序の解析 (2016)
  • Author(s): 三島健一、鬼頭浩史、岡部由香、松下雅樹、西田佳弘、石黒直樹、大野欽司
  • Organizer: 第34回日本骨代謝学会・第3回アジア太平洋骨代謝学会
  • Place of Presentation: 大阪国際会議場（大阪市北区）
  • Year and Date: 2016-07-20
  • Int'l Joint Research
• [Presentation] Meclozineによる軟骨無形成症の根本的治療の可能性と限界 (2016)
  • Author(s): 松下雅樹、鬼頭浩史、三島健一、杉浦洋、西田佳弘、石黒直樹、大野欽司
  • Organizer: 第34回日本骨代謝学会・第3回アジア太平洋骨代謝学会
  • Place of Presentation: 大阪国際会議場（大阪市北区）
  • Year and Date: 2016-07-20
  • Int'l Joint Research
• [Presentation] Clinically attainable concentration of meclozine promotes bone growth in transgenic mice with achondroplasia (2016)
  • Author(s): Matsushita M, Kitoh H, Mishima K, Nishida Y, Ishiguro N, Ohno K
  • Organizer: Gordon Research Conference
  • Place of Presentation: Hong Kong （China）
  • Year and Date: 2016-06-05
  • Int'l Joint Research
• [Presentation] Genu varum in achondroplasia and hypochondroplasia (2016)
  • Author(s): Hiroshi Kitoh, Kenichi Mishima, Masaki Matsushita. Hiroshi Sugiura, Sachi Hasegawa, Naoki Ishiguro
  • Organizer: Annual meeting of Pediatric Orthopedic Society of North America
  • Place of Presentation: Indianapolis （ＵＳＡ）
  • Year and Date: 2016-04-27
  • Int'l Joint Research
• [Presentation] Treatment strategies for short stature in achondroplasia (2016)
  • Author(s): Hiroshi Kitoh, Kenichi Mishima, Masaki Matsushita
  • Organizer: 13th International Congress of Human Genetics
  • Place of Presentation: 国立京都国際会館（京都市左京区）
  • Year and Date: 2016-04-03
  • Int'l Joint Research
• [Presentation] 整形外科領域における低ホスファターゼ症 (2015)
  • Author(s): 鬼頭浩史
  • Organizer: 第26回日本小児整形外科学会
  • Place of Presentation: 長良川国際会議場（岐阜県岐阜市）
  • Year and Date: 2015-12-04
• [Presentation] Transplantation of culture-expanded bone marrow cells and platelet rich plasma during distraction osteogenesis of the long bones (2015)
  • Author(s): Hiroshi Kitoh, Kenichi Mishima, Masaki Matsushita, Naoki Ishiguro
  • Organizer: 4th Tissue Engineering and Regenerative Medicine International Society
  • Place of Presentation: Boston,U.S.A.
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] Promoting osteoblastogenesis using Lansoprazole (2015)
  • Author(s): Kenichi Mishima, Bisei Ohkawara, Hiroshi Kitoh, Yuta Tsukagoshi Okabe, Hiroshi Sugiura, Masaki Matsushita, Naoki Ishiguro, Kinji Ohno
  • Organizer: 4th Tissue Engineering and Regenerative Medicine International Society
  • Place of Presentation: Boston,U.S.A.
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] Transplantation of culture-expanded bone marrow cells and platelet rich plasma in lower limb lengthening for short stature patients (2015)
  • Author(s): Hiroshi Kitoh, Kenichi Mishima, Masaki Matsushita, Naoki Ishiguro
  • Organizer: The 7th International Conference on Children’s Bone Health
  • Place of Presentation: Salzburg,Austria
  • Year and Date: 2015-06-27
  • Int'l Joint Research
• [Presentation] Meclozine has a potential effect on short stature and foramen magnum stenosis in transgenic mice with achondroplasia (2015)
  • Author(s): Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Hiroshi Sugiura, Sachi Hasegawa, Akiko Kitamura, Naoki Ishiguro, Ohno Kinj.
  • Organizer: The 7th International Conference on Children’s Bone Health
  • Place of Presentation: Salzburg,Austria
  • Year and Date: 2015-06-27
  • Int'l Joint Research
• [Book] 今日の整形外科治療指針7版 (2016)
  • Author(s): 鬼頭浩史
  • Total Pages: 11
  • Publisher: 医学書院
• [Book] 小児整形外科テキスト改訂第2版 (2016)
  • Author(s): 鬼頭浩史
  • Total Pages: 6
  • Publisher: メジカルビュー社
• [Book] 今日の治療指針2015年 (2015)
  • Author(s): 鬼頭浩史
  • Total Pages: 1973
  • Publisher: 医学書院
• [Book] 今日の小児治療指針 (2015)
  • Author(s): 鬼頭浩史
  • Total Pages: 1006
  • Publisher: 医学書院
• [Book] 肢体不自由児の医療・療育・教育 (2015)
  • Author(s): 鬼頭浩史
  • Total Pages: 262
  • Publisher: 金芳堂