Research Project
Grant-in-Aid for Challenging Exploratory Research
CINCA syndrome is one of auto-inflammatory diseases with a heterozygous mutation of NLRP3 gene and characterized as showing joint deformities along with symptoms related to chronic inflammation. To investigate the molecular mechanisms causing the abnormal growth plate, iPS cells with and without mutant NLRP3 gene were established and labeled with different markers, which can distinguish them. Chondrocytes were induced from each type of iPS cells and were cultured under the condition in which they shared culture supernatants. The results indicated that chondrocytes with mutant NLPR3 affected the phenotype of chondrocytes without the mutant gene by producing soluble factors.
All 2016 2015
All Journal Article (6 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 6 results, Open Access: 4 results, Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 4 results, Invited: 5 results)
Proc. Natl. Acad. Sci. U S A
Volume: 113 Pages: 13057-13062
Proc Natl Acad Sci USA
Volume: 112 Issue: 50 Pages: 15438-15443
10.1073/pnas.1510540112
Human Genome Variation
Volume: 2 Issue: 1 Pages: 15055-15055
10.1038/hgv.2015.55
Stem Cells.
Volume: 印刷中 Issue: 6 Pages: 1730-1742
10.1002/stem.1981
Cell Death Differ
Volume: 22 Issue: 5 Pages: 852-861
10.1038/cdd.2014.192
Arthritis Rheumatol
Volume: 67 Issue: 1 Pages: 302-314
10.1002/art.38912
