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Research on restoration of neural networks after spinal cord injuries

Research Project

Project/Area Number 15K15550
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionKyoto University

Principal Investigator

Nishio Takeshi  京都大学, 医学研究科, 助教 (70303790)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords軸索再生 / 軸索断片 / 軸索-グリア複合体 / 成熟ラット / 脊髄切断
Outline of Final Research Achievements

Axonal regeneration is very limited after transection of adult rat spinal cord. We previously demonstrated that regenerative axons reached the lesion site within 6 hours of sharp transection with a thin scalpel. However, they failed to grow across the lesion site, where injured axon fragments (axon-glial complex, AGC) were accumulated. Considering a possible role of these axon fragments as physicochemical barriers, we examined the effects of prompt elimination of the barriers on axonal growth beyond the lesion site. In this study, we made additional oblique section immediately after the primary transection and surgically eliminated the AGC (debridement). Under this treatment, regenerative axons successfully traversed the lesion site within 4 hours of surgery. These results suggest that the sequential trial of reduction and early elimination of the physicochemical barriers is one of effective approaches to induce spontaneous and rapid regeneration beyond the lesion site.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Immediate elimination of injured white matter tissue achieves a rapid axonal growth across the severed spinal cord in adult rats2018

    • Author(s)
      Takeshi Nishio, Hiroshi Fujiwara, Isaku Kanno
    • Journal Title

      Neuroscience Research

      Volume: 印刷中 Pages: 19-29

    • DOI

      10.1016/j.neures.2017.10.011

    • NAID

      120006473631

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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