| Project/Area Number |
15K15552
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Ehime University |
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Principal Investigator |
Imai Yuuki 愛媛大学, プロテオサイエンスセンター, 教授 (10423873)
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| Co-Investigator(Renkei-kenkyūsha) |
SAWASAKI Tatsuya 愛媛大学, プロテオサイエンスセンター, 教授 (50314969)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 特発性大腿骨頭壊死 / ステロイド / グルココルチコイド / 大腿骨頭壊死 |
|---|
| Outline of Final Research Achievements |
To clarify the mechanism of the onset and progress of steroid-induced osteonecrosis of femoral head, we tried to identify the proteins interacting with Glucocorticoid Receptor (GR) using screening system of cell-free technology for protein analysis. As the results, we successfully identified more than 300 proteins, which interact with GR including not only reported proteins but also non-reported proteins relate to autophagy. This result indicates that steroid-induced osteonecrosis can be partly caused by protein degradation of non-genomic GR action as well as genomic actions.
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