| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
To identify the cofactor controlling Arkadia and to elucidate its molecular mechanism, screening of Arkadia binding protein was performed to obtain a candidate gene. Smad6 was identified as a new Arkadia target protein, Arkadia promotes differentiation by predominantly activating BMP signal during the late stage differentiation of osteoblasts, and ubiquitinates Smad6 which selectively suppresses BMP signal leading to degradation. A marked abnormality was found in the knockout mouse of E3 ubiquitin ligase Smurf 2 that negatively regulates the BMP signal prepared as a comparison target of Arkadia analysis.
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