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Development of novel target therapy for metastatic organ of malignant soft tissue tumor

Research Project

Project/Area Number 15K15560
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research Institution医療法人徳洲会野崎徳洲会病院(附属研究所) (2016-2017)
Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2015)

Principal Investigator

Itoh Kazuyuki  医療法人徳洲会野崎徳洲会病院(附属研究所), 研究所, 所長 (20301806)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肺転移 / スフェロイド / 肉腫 / 骨肉腫 / 肺線維化 / Cachexia / metastasis / lung / CTC / Osteosarcoma / VEGF
Outline of Final Research Achievements

Prognosis of malignant soft tissue tumor clinically depended on the lung metastasis. Recently, critical roles of spheroid formation and dynamics during metastasis formation was emphasized. We herein newly developed macro-microscopy with near-infrared light. Employing this system, we could analyze the marginal zones and also intra regions of malignant soft tissue tumor spheroid with time-lapse recording.
Numerous filopodias were observed surrounding spheroid with Cdc42-dependent fashion and budding (
sprouting) formation were observed occasionally with Rho-Rho-kinase (ROCK) dependent manner. We are currently analyzing this spheroid dynamics with several compounds, which already confirmed showing the inhibitory effects for the same soft tissue tumor in vitro and also in vivo Xenograft model.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016 2015

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (14 results) Book (1 results)

  • [Journal Article] Evidence for intrathecal sodium butyrate as a novel option for leptomeningeal metastasis.2018

    • Author(s)
      Nakagawa H, Yui Y, Sasagawa S, Itoh K.
    • Journal Title

      Journal of Neuro-Oncology

      Volume: 印刷中 Issue: 1 Pages: 43-50

    • DOI

      10.1007/s11060-018-2852-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sodium butyrate induces senescence and inhibits the invasiveness of glioblastoma cells.2018

    • Author(s)
      Nakagawa H, Sasagawa S, Itoh K.
    • Journal Title

      Oncology letter

      Volume: 15(2) Pages: 1495-1502

    • DOI

      10.3892/ol.2017.7518

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of effective tumor immunotherapy using a novel dendritic cell?targeting Toll-like receptor ligand2017

    • Author(s)
      De Silva Nadeeka H.、Akazawa Takashi、Wijewardana Viskam、Inoue Norimitsu、Oyamada Maremichi、Ohta Atsuko、Tachibana Yuki、Wijesekera Daluthgamage Patsy H.、Kuwamura Mitsuru、Nishizawa Yasuko、Itoh Kazuyuki、Izawa Takeshi、Hatoya Shingo、Hasegawa Tetsuya、Yamate Jyoji、Inaba Toshio、Sugiura Kikuya
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 11 Pages: 0188738-0188738

    • DOI

      10.1371/journal.pone.0188738

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trabectedin is a promising antitumor agent potentially inducing melanocytic differentiation for clear cell sarcoma2017

    • Author(s)
      Nakai Takaaki、Imura Yoshinori、Tamiya Hironari、Yamada Shutaro、Nakai Sho、Yasuda Naohiro、Kaneko Keiko、Outani Hidetatsu、Takenaka Satoshi、Hamada Kenichiro、Myoui Akira、Araki Nobuhito、Ueda Takafumi、Itoh Kazuyuki、Yoshikawa Hideki、Naka Norifumi
    • Journal Title

      Cancer Medicine

      Volume: 6 Issue: 9 Pages: 2121-2130

    • DOI

      10.1002/cam4.1130

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapeutic potential of TAS-115 via c-MET and PDGFRα signal inhibition for synovial sarcoma.2017

    • Author(s)
      Yamada S, Imura Y, Nakai T, Nakai S, Yasuda N, Kaneko K, Outani H, Takenaka S, Hamada K, Myoui A, Araki N, Ueda T, Itoh K, Yoshikawa H, Naka N.
    • Journal Title

      BMC Cancer

      Volume: 17(1) Issue: 1 Pages: 334-334

    • DOI

      10.1186/s12885-017-3324-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trabectedin is a promising antitumour agent for synovial sarcoma2016

    • Author(s)
      Yasui, H., Imura, Y., Outani, H., Hamada, K., Nakai, T., Yamada, S., Takenaka, S., Sasagawa, S., Araki, N., Itoh, K., Myoui, A., Yoshikawa, H., & Naka, N.
    • Journal Title

      Journal of Chemotherapy

      Volume: e-pub ahead of print Issue: 5 Pages: 1-8

    • DOI

      10.1080/1120009x.2015.1133013

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Daphnetin inhibits invasion and migration of LM8 murine osteosarcoma cells by decreasing RhoA and Cdc42 expression2016

    • Author(s)
      Hiroki Fukuda, Seikou Nakamura, Yugo Chisaki, Tetsuya Takada, Yuki Toda, Hiroaki Murata, Kazuyuki Itoh, Yoshitaka Yano, Kazuyuki Takata, Eishi Ashihara
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 471 Issue: 1 Pages: 63-67

    • DOI

      10.1016/j.bbrc.2016.01.179

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ephedrae herba stimulates hepatocyte growth factor-induced MET endocytosis and downregulation via early/late endocytic pathways in gefitinib-resistant human lung cancer cells2016

    • Author(s)
      Nishimura, Y., Hyuga, S., Takiguchi, S., Hyuga, M., Itoh, K., Hanawa, T.
    • Journal Title

      International Journal of Oncology

      Volume: 48(5) Issue: 5 Pages: 1895-1906

    • DOI

      10.3892/ijo.2016.3426

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional and therapeutic relevance of hepatocyte growth factor/c-MET signaling in synovial sarcoma.2016

    • Author(s)
      Imura Y, Nakai T, Yamada S, Outani H, Takenaka S, Hamada K, Araki N, Itoh K, Yoshikawa H, Naka N.
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 12 Pages: 1867-1876

    • DOI

      10.1111/cas.13092

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 淡明細胞肉腫に対するtrabectedin (Yondelis; ET-743)の抗腫瘍効果2017

    • Author(s)
      中井隆彰、伊村慶紀、中井翔、安田直弘、山田修太郎、金子恵子、王谷英達、竹中聡、濱田健一郎、名井陽、荒木信人、上田孝文、伊藤和幸、吉川秀樹、中紀文
    • Organizer
      第50回骨軟部腫瘍学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 淡明細胞肉腫に対するeribulin mesilateの抗腫瘍効果2017

    • Author(s)
      中井翔、中井隆彰、安田直弘、山田修太郎、金子恵子、竹中聡、濱田健一郎、名井陽、荒木信人、上田孝文、伊藤和幸、吉川秀樹、中紀文
    • Organizer
      第50回骨軟部腫瘍学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アンドロゲンとビタミンD3による前立腺癌の細胞増殖調節2016

    • Author(s)
      五十嵐晃、渡邉健太、由井理洋、笹川覚、平田美智子、稲田全規、宮浦千里、伊藤和幸
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] NET過剰発現非小細胞肺がんの増殖に対する麻黄及びエルロチニブの併用効果2016

    • Author(s)
      日向須美子、日向昌司、西村行生、伊藤和幸、小田口浩、花輪壽彦
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 骨軟部腫瘍におけるTwist1による転移能調節2016

    • Author(s)
      笹川覚、由井理洋、中川秀光、伊藤和幸
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] TAS-115は単剤で、c-METまたはPDGFRαシグナルに依存した複数の滑膜肉腫細胞株に対し抗腫瘍効果を発揮する2016

    • Author(s)
      山田修太郎、井村慶紀、中井隆彰、王谷英達、金子恵子、竹中聡、濱田健一郎、名井陽、荒木信人、上田孝文、伊藤和幸、吉川秀樹、中紀文
    • Organizer
      第49回骨・軟部腫瘍学術集会
    • Place of Presentation
      東京ドームホテル
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 滑膜肉腫細胞株におけるTAS-115の抗腫瘍効果:TAS-115はMET signalのみならずPDGFRα signalも抑制する2015

    • Author(s)
      山田修太郎、伊村慶紀、中井隆彰、金子恵子、荒木信人、伊藤和幸、吉川秀樹、中紀文
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 滑膜肉腫に対する選択的c-MET阻害剤(INC280)の感受性を予知するバイオマーカーの探索2015

    • Author(s)
      伊村慶紀、中井隆彰、山田修太郎、王谷英達、濱田健一郎、金子恵子、名井陽、荒木信人、伊藤和幸、吉川秀樹、中紀文
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規マウス軟部肉腫高肺転移株樹立の試み2015

    • Author(s)
      金子恵子、中紀文、伊村慶紀、中井隆彰、山田修太郎、濱田健一郎、王谷英達、伊藤和幸、吉川秀樹
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 淡明細胞肉腫に対するtrabectedin(Yondelis; ET-743)の抗腫瘍効果2015

    • Author(s)
      中井隆彰、伊村慶紀、山田修太郎、金子恵子、王谷英達、濱田健一郎、名井陽、荒木信人、伊藤和幸、吉川秀樹、中紀文
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 日本がん転移学会と共に2015

    • Author(s)
      伊藤和幸
    • Organizer
      第24回日本がん転移学会学術集会・総会
    • Place of Presentation
      シティプラザ大阪(大阪府大阪市)
    • Year and Date
      2015-07-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 滑膜肉腫におけるMETシグナルの役割とMET阻害剤に対する感受性を予知するバイオマーカーの探索2015

    • Author(s)
      伊村慶紀、王谷英達、中井隆彰、山田修太郎、濱田健一郎、名井陽、荒木信人、上田孝文、伊藤和幸、吉川秀樹、中紀文
    • Organizer
      第48回日本整形外科学会 骨・軟部腫瘍学術集会
    • Place of Presentation
      かがわ国際会議場(香川県高松市)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 淡明細胞肉腫に対するtrabectedin (Yondelis; ET-743)の有効性2015

    • Author(s)
      中井隆彰、伊村慶紀、山田修太郎、金子恵子、王谷英達、濱田健一郎、名井陽、荒木信人、上田孝文、伊藤和幸、吉川秀樹、中紀文
    • Organizer
      第48回日本整形外科学会 骨・軟部腫瘍学術集会
    • Place of Presentation
      かがわ国際会議場(香川県高松市)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 滑膜肉腫細胞株に対するTAS-115の抗腫瘍効果の検討2015

    • Author(s)
      山田修太郎、伊村慶紀、中井隆彰、王谷英達、濱田健一郎、名井陽、荒木信人、上田孝文、伊藤和幸、吉川秀樹、中紀文
    • Organizer
      第48回日本整形外科学会 骨・軟部腫瘍学術集会
    • Place of Presentation
      かがわ国際会議場(香川県高松市)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Research-status Report
  • [Book] Osteosarcoma A Multidisciplinary Approach to Treatment2016

    • Author(s)
      Toguchida T, Itoh K, Tsukahara T, Ogura K, Nishida Y, Kaya M, Hiraga H, Kakunaga S, Matsumine A, Futani H, Kunisada T, Morii T, Araki N, Ae K, Tsuchiya H, Matsubara H, Matsumoto S, Imai R, Iwata S, Yonemoto T. 他
    • Total Pages
      270
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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