Development of novel target therapy for metastatic organ of malignant soft tissue tumor
Project/Area Number |
15K15560
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | 医療法人徳洲会野崎徳洲会病院(附属研究所) (2016-2017) Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2015) |
Principal Investigator |
Itoh Kazuyuki 医療法人徳洲会野崎徳洲会病院(附属研究所), 研究所, 所長 (20301806)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 肺転移 / スフェロイド / 肉腫 / 骨肉腫 / 肺線維化 / Cachexia / metastasis / lung / CTC / Osteosarcoma / VEGF |
Outline of Final Research Achievements |
Prognosis of malignant soft tissue tumor clinically depended on the lung metastasis. Recently, critical roles of spheroid formation and dynamics during metastasis formation was emphasized. We herein newly developed macro-microscopy with near-infrared light. Employing this system, we could analyze the marginal zones and also intra regions of malignant soft tissue tumor spheroid with time-lapse recording. Numerous filopodias were observed surrounding spheroid with Cdc42-dependent fashion and budding ( sprouting) formation were observed occasionally with Rho-Rho-kinase (ROCK) dependent manner. We are currently analyzing this spheroid dynamics with several compounds, which already confirmed showing the inhibitory effects for the same soft tissue tumor in vitro and also in vivo Xenograft model.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Therapeutic potential of TAS-115 via c-MET and PDGFRα signal inhibition for synovial sarcoma.2017
Author(s)
Yamada S, Imura Y, Nakai T, Nakai S, Yasuda N, Kaneko K, Outani H, Takenaka S, Hamada K, Myoui A, Araki N, Ueda T, Itoh K, Yoshikawa H, Naka N.
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Journal Title
BMC Cancer
Volume: 17(1)
Issue: 1
Pages: 334-334
DOI
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Peer Reviewed / Open Access
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[Journal Article] Trabectedin is a promising antitumour agent for synovial sarcoma2016
Author(s)
Yasui, H., Imura, Y., Outani, H., Hamada, K., Nakai, T., Yamada, S., Takenaka, S., Sasagawa, S., Araki, N., Itoh, K., Myoui, A., Yoshikawa, H., & Naka, N.
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Journal Title
Journal of Chemotherapy
Volume: e-pub ahead of print
Issue: 5
Pages: 1-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Ephedrae herba stimulates hepatocyte growth factor-induced MET endocytosis and downregulation via early/late endocytic pathways in gefitinib-resistant human lung cancer cells2016
Author(s)
Nishimura, Y., Hyuga, S., Takiguchi, S., Hyuga, M., Itoh, K., Hanawa, T.
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Journal Title
International Journal of Oncology
Volume: 48(5)
Issue: 5
Pages: 1895-1906
DOI
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Peer Reviewed / Open Access
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[Presentation] 日本がん転移学会と共に2015
Author(s)
伊藤和幸
Organizer
第24回日本がん転移学会学術集会・総会
Place of Presentation
シティプラザ大阪(大阪府大阪市)
Year and Date
2015-07-23
Related Report
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[Book] Osteosarcoma A Multidisciplinary Approach to Treatment2016
Author(s)
Toguchida T, Itoh K, Tsukahara T, Ogura K, Nishida Y, Kaya M, Hiraga H, Kakunaga S, Matsumine A, Futani H, Kunisada T, Morii T, Araki N, Ae K, Tsuchiya H, Matsubara H, Matsumoto S, Imai R, Iwata S, Yonemoto T. 他
Total Pages
270
Publisher
Springer
Related Report