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Establishment of the droplet lamination method of volatile anesthetic and membrane interaction on ion channel

Research Project

Project/Area Number 15K15567
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionUniversity of Fukui

Principal Investigator

Matsuki Yuka  福井大学, 学術研究院医学系部門, 助教 (10464083)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsCBB / 揮発性麻酔薬 / イオンチャネル
Outline of Final Research Achievements

To establish the method of administering a volatile anesthetic to a lipid bilayer membrane,we started to establish the contact bubble bilayer method(CBB method). Compared to the conventional method, the size of the dloplet was decreased to one tenth in CBB method.In particular, lipophilic molecules are difficult to dissolve into membranes.It was the first time of dissolving lipophilic molecules into membranes.It was also possible to establish a method of spraying chloroform or a volatile anesthetic into membranes by CBB method.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Rectified Proton Grotthuss Conduction Across a Long Water-Wire in the Test Nanotube of the Polytheonamide B Channel.2016

    • Author(s)
      Matsuki, Y., Iwamoto, M. Mita, K., Shigemi, K., Matsunaga, S., and Oiki
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 138 Issue: 12 Pages: 4168-4177

    • DOI

      10.1021/jacs.5b13377

    • NAID

      120006226473

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A case of successful treatment with vasopressin for severe acute pancreatitis in a melancholic patient administrated antipsychotic agents2016

    • Author(s)
      Matsuki Y, Takakura K, Shigemi K
    • Journal Title

      Anaesth Pain & Intensive Care

      Volume: 20(1) Pages: 71-73

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] General anesthesia and intraoperative opioids do not affect postoperative delirium in femoral neck surgery2015

    • Author(s)
      Matsuki Y, Takakura K, Shigemi K
    • Journal Title

      Anaesth Pain & Intensive Care

      Volume: 19(3) Pages: 372-375

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Effects of an artificial lipid, dipalmitoyl sulfobetaine, on the function of ion channel2018

    • Author(s)
      松木悠佳
    • Organizer
      日本生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Rectified proton permeation across a single-file water-chain in the channel pore2017

    • Author(s)
      松木悠佳
    • Organizer
      日本生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] チャネルのプロトン透過と水分子2017

    • Author(s)
      老木成稔, 松木悠佳, 岩本真幸
    • Organizer
      第3回「水シグナリングの分子動態から病態へ」研究会
    • Place of Presentation
      アオッサ(福井市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Rectified proton permeation across a single-file water-chain in the channel pore2017

    • Author(s)
      Y. Matsuki, M. Iwamoto, S.Oiki
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(浜松市)
    • Related Report
      2016 Research-status Report
  • [Presentation] pH-dependent gating of the polytheoamide B channel2015

    • Author(s)
      松木悠佳, 岩本真幸, 松永茂樹, 老木成稔
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学(金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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