Establishment of the droplet lamination method of volatile anesthetic and membrane interaction on ion channel
| Project/Area Number |
15K15567
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | University of Fukui |
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Principal Investigator |
Matsuki Yuka 福井大学, 学術研究院医学系部門, 助教 (10464083)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | CBB / 揮発性麻酔薬 / イオンチャネル |
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| Outline of Final Research Achievements |
To establish the method of administering a volatile anesthetic to a lipid bilayer membrane,we started to establish the contact bubble bilayer method(CBB method). Compared to the conventional method, the size of the dloplet was decreased to one tenth in CBB method.In particular, lipophilic molecules are difficult to dissolve into membranes.It was the first time of dissolving lipophilic molecules into membranes.It was also possible to establish a method of spraying chloroform or a volatile anesthetic into membranes by CBB method.
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Report
(4 results)
Research Products
(8 results)
