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Impact of anesthesia on cancer recurrence and metastasis: anaylsis of circulating tumor DNA

Research Project

Project/Area Number 15K15568
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionShinshu University

Principal Investigator

KAWAMATA Mikito  信州大学, 学術研究院医学系, 教授 (90315523)

Co-Investigator(Kenkyū-buntansha) 石田 高志  信州大学, 医学部附属病院, 助教(特定雇用) (60531952)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords末梢血腫瘍DNA / 周術期 / がん転移 / 麻酔法 / がん再発 / circulating tumor DNA / 麻酔方法
Outline of Final Research Achievements

In order to investigate the effect of anesthesia and perioperative management on the recurrence and metastasis of postoperative cancer, we measured the circulating cancer cell DNA (ctDNA) such as BRAF was measured in the peripheral blood in the peripheral blood during the perioperative period in patients with malignant melanoma and pulmonary carcinoma, in relation to anesthetic techniques and cytokines in the blood. There was no patients with malignant melanoma in whom a new BRAF gene mutation was detected during the perioperative period. No new mutant ctDNA could be detected at the perioperative period, even if patients with pulmonary carcinoma were enrolled in this study. In order to investigate the effect of anesthesia on ctDNA, it seems necessary to consider management of palliative care etc in patients with end-stage cancer.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2016 2015

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 9 results,  Acknowledgement Compliant: 4 results) Presentation (3 results) (of which Invited: 2 results) Book (7 results)

  • [Journal Article] Spinal nociceptive transmission by mechanical stimulation of bone marrow2016

    • Author(s)
      Ishida T, Tanaka S, Sekiguchi T, Sugiyama D, Kawamata M
    • Journal Title

      Molecular Pain

      Volume: 12 Pages: 1-15

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Systemic QX-314 Reduces Bone Cancer Pain through Selective Inhibition of Transient Receptor Potential Vanilloid Subfamily 1-expressing Primary Afferents in Mice2016

    • Author(s)
      Fuseya S, Yamamoto K, Minemura H, Yamaori S, Kawamata T, Kawamata M
    • Journal Title

      Anesthesiology

      Volume: 125 Issue: 1 Pages: 204-218

    • DOI

      10.1097/aln.0000000000001152

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in synaptic transmission of substantia gelatinosa neurons after spinal cord hemisection revealed by analysis using in vivo patch-clamp recording.2016

    • Author(s)
      Kozuka Y, Kawamata M, Furue H, Ishida T, Tanaka S, Namiki A, Yamakage M
    • Journal Title

      Mol Pain

      Volume: 12 Pages: 1-14

    • DOI

      10.1177/1744806916665827

    • NAID

      120007100116

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Systematic review of motor evoked potentials monitoring during thoracic and thoracoabdominal aortic aneurysm open repair surgery: a diagnostic meta-analysis2016

    • Author(s)
      Tanaka Y, Kawaguchi M, Noguchi Y, Yoshitani K, Kawamata M, Masui K, Nakayama T, Yamada Y
    • Journal Title

      J Anesth

      Volume: 30 Issue: 6 Pages: 1037-1050

    • DOI

      10.1007/s00540-016-2242-x

    • NAID

      40021034848

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of Temporary Transvenous Pacing to Prevent Atropine-resistant Bradycardia during Surgery for a Tumor in the Brainstem Region: A Case Report2016

    • Author(s)
      Yoshiyama Y, Sugiyama Y, Ide S, Fuseya S, Murakami T, Kawamata M
    • Journal Title

      Shinshu Medical Journal

      Volume: 64 Pages: 153-157

    • NAID

      130005160166

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] McGRATH MAC video laryngoscope for insertion of a transoesophageal echocardiography probe A randomised controlled trial2016

    • Author(s)
      Ishida T, Kiuchi C, Sekiguchi T, Tsujimoto T, Kawamata M
    • Journal Title

      Eur J Anaesthesiol

      Volume: 33 Issue: 4 Pages: 263-8

    • DOI

      10.1097/eja.0000000000000367

    • NAID

      120007100117

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Severe Re-expansion Pulmonary Edema Induced by One-Lung Ventilation.2015

    • Author(s)
      Sugiyama Y, Shimizu F, Shimizu S, Urasawa M, Tanaka S, Kawamata M.
    • Journal Title

      Respir Care

      Volume: 60 Issue: 8 Pages: e134-e140

    • DOI

      10.4187/respcare.03759

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transversus abdominis plane block with 0.25 % levobupivacaine: a prospective, randomized, double‐blinded clinical study2015

    • Author(s)
      Ishida T, Sakamoto A, Tanaka H, Ide S, Ishida K, Tanaka S, Mori T, Kawamata M
    • Journal Title

      J Anesth

      Volume: 29 Issue: 4 Pages: 557-61

    • DOI

      10.1007/s00540-015-1993-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] In vivo support for the new concept of pulmonary blood flow-mediated CO2 gas excretion in the lungs2015

    • Author(s)
      Kawai Y, Ajima K, Kaidoh M, Sakaguchi M, Tanaka S, Kawamata M, Kimura H, and Ohhashi T
    • Journal Title

      Am J Physiol Lung Mol

      Volume: in press Issue: 12 Pages: 263-8

    • DOI

      10.1152/ajplung.00205.2014

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Conscious Sedation and Awake Fiberoptic Intubation in a Patient with Difficult Mask Ventilation--A Case Report2015

    • Author(s)
      Baral B, Ide S, Uzawa M, Kiyosawa K, Sasaki H, Kawamata M
    • Journal Title

      Open Journal of Anesthesiology

      Volume: 5 Issue: 09 Pages: 206-210

    • DOI

      10.4236/ojanes.2015.59037

    • NAID

      120007100118

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Acute Post-Operative Pain: Mechanisms, Treatment, and Prevention of Chronification2016

    • Author(s)
      Kawamata M
    • Organizer
      第16回国際疼痛学会(IASP)
    • Place of Presentation
      Yokohama(パシフィコ横浜)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 明日からできる臨床研究の上手な進め方:今後の日本での臨床研究の方向性.2015

    • Author(s)
      川真田 樹人
    • Organizer
      日本臨床麻酔学会 第35回大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市西区みなとみらい)
    • Year and Date
      2015-10-21
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 非麻薬性鎮痛薬2015

    • Author(s)
      川真田 樹人
    • Organizer
      日本ペインクリニック学会第49回大会
    • Place of Presentation
      グランフロント大阪(大阪府大阪市北区大深町)
    • Year and Date
      2015-07-23
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 痛みの生理学. 麻酔科学レビュー 最新主要文献集 20162016

    • Author(s)
      川真田 樹人
    • Publisher
      総合医学社
    • Related Report
      2016 Annual Research Report
  • [Book] 脳・脊髄腫瘍の麻酔管理. 神経麻酔2016

    • Author(s)
      田中 聡, 布施谷 仁志, 川真田 樹人
    • Total Pages
      6
    • Publisher
      克誠堂出版
    • Related Report
      2016 Annual Research Report
  • [Book] 覚醒下手術の麻酔管理. 神経麻酔2016

    • Author(s)
      布施谷 仁志, 石田 高志, 川真田 樹人
    • Publisher
      克誠堂出版
    • Related Report
      2016 Annual Research Report
  • [Book] 脊髄くも膜下麻酔・硬膜外麻酔後の神経障害. 麻酔科医のための周術期危機管理と合併症への対応2016

    • Author(s)
      石田 高志, 川真田 樹人
    • Publisher
      中山書店
    • Related Report
      2016 Annual Research Report
  • [Book] 局所麻酔. エビデンスで読み解く小児麻酔2016

    • Author(s)
      峰村 仁志, 川真田 樹人
    • Publisher
      克誠堂出版
    • Related Report
      2016 Annual Research Report
  • [Book] 脊髄くも膜下麻酔・硬膜外麻酔. 麻酔科学文献レビュー2015~2016 総括・文献紹介2015

    • Author(s)
      川真田 樹人
    • Total Pages
      292
    • Publisher
      秀潤社
    • Related Report
      2015 Research-status Report
  • [Book] 痛みの伝導機構と区域麻酔. 麻酔科医のための区域麻酔スタンダード2015

    • Author(s)
      川真田 樹人, 峰村 仁志
    • Total Pages
      304
    • Publisher
      中山書店
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-04-03  

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