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Evaluation of combined exposure of sevoflurane and anti cancer drugs

Research Project

Project/Area Number 15K15569
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionNagoya University

Principal Investigator

Hirai Takahiro  名古屋大学, 医学部附属病院, 病院助教 (00612798)

Research Collaborator Nishiwaki Kimitoshi  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsセボフルラン / がん細胞株 / 吸入麻酔薬 / フルオロウラシル / 抗癌剤 / シスプラチン
Outline of Final Research Achievements

Some of anticancer drugs which mimic DNA component were taken to cancer cell when the cells were in cell cycle progression. To date we have investigated some of cancer cells were slightly increased cell population accompanied with DNA replication. Whereas our continuous study with this theme, we found that sevoflurane exposed cells that cultured with anti-cancer drug for 24 hours did not show significant reduction compared with anti cancer single treatment control.

Academic Significance and Societal Importance of the Research Achievements

本研究でセボフルラン暴露後にがん細胞株がDNA合成期を増加させたことを利用し、セボフルランと抗癌剤の併用培養によって抗がん剤の薬剤感受性を高めると考えこれを検証した。しかし、予想したような結果は得られなかった。また一部の抗がん剤は暴露が原因とする細胞死抵抗性を高めたことから、より効果的な添加方法など検討が必要である。期待した成果は得られなかったが、増加するがん患者さんの治療に考慮した麻酔薬の基礎データ提供の足掛かりになると考える。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016

All Presentation (11 results) (of which Int'l Joint Research: 4 results)

  • [Presentation] 1% Sevoflurane exposure is associated with early and late apoptotic cell death onA549 and MCF-7 cell lines2018

    • Author(s)
      Takahiro Hirai YK, and Kimitoshi Nishiwaki
    • Organizer
      American Society of Anesthesiologists (ASA)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 吸入麻酔薬セボフルラン暴露後にヒトがん培養細胞株が示す増殖能の変化2018

    • Author(s)
      小西裕子、周睿、林智子、平井昂宏、西脇公俊
    • Organizer
      第59回日本肺癌学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] セボフルラン暴露後に生じる大腸癌細胞株の短期的な増殖はERK1/2のリン酸化が関与する2017

    • Author(s)
      平井昂宏、小西裕子、周睿、西脇公俊
    • Organizer
      日本麻酔科学会 第64回学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] ヒト大腸がん細胞株を用いたセボフルラン暴露と足場非依存性増殖能の検討(優秀演題)2017

    • Author(s)
      小西裕子、周睿、平井昂宏、西脇公俊
    • Organizer
      日本麻酔科学会 第64回学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Sevoflurane stimulates MAPK1/3 phosphorylation after its exposure and caused short cell growth on HCT1162017

    • Author(s)
      Takahiro Hirai, Yuko Konishi and Kimitoshi Nishiwaki
    • Organizer
      American Society of Anesthesiologists
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sevoflurane partly promotes cancer cell growth2017

    • Author(s)
      Yuko Konishi, Takahiro Hirai, Sachiko Mizuno and Kimitoshi Nishiwaki
    • Organizer
      5th Global Conference on Perioperative Care of the Cancer Patient
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sevoflurane stimulates MAPK1/3 phosphorylation after its exposure and caused short cell growth on HCT1162016

    • Author(s)
      Yuko Konishi, Takahiro Hirai and Kimitoshi Nishiwaki
    • Organizer
      The 4th Global Conference on the Perioperative Care of the Cancer Patient
    • Place of Presentation
      London, England
    • Year and Date
      2016-11-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 各種ヒトがん細胞に与えるセボフルラン暴露影響の予備的研究2016

    • Author(s)
      平井 昂宏、小西裕子、西脇公俊
    • Organizer
      日本麻酔科学会 第63回学術集会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] セボフルランのヒト大腸がん細胞株へ及ぼす影響1―HCT116におけるS期細胞増加について―2016

    • Author(s)
      小西裕子、平井昂宏、水野祥子、西脇公俊
    • Organizer
      日本麻酔科学会 第63回学術集会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] セボフルランのヒト大腸がん細胞株へ及ぼす影響2 -HCT116トランスクリプトーム解析-2016

    • Author(s)
      小西裕子、水野祥子、平井昂宏、西脇公俊
    • Organizer
      日本麻酔科学会 第63回学術集会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 各種ヒトがん細胞に与えるセボフルラン暴露影響の予備的研究2016

    • Author(s)
      平井 昂宏、小西裕子、西脇公俊
    • Organizer
      日本麻酔科学会第63回学術集会
    • Place of Presentation
      福岡国際会議場(福岡県、福岡市)
    • Year and Date
      2016-05-26
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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