The mechanism of propofol infusion syndrome and the prevention effects by canrnitine
| Project/Area Number |
15K15573
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
堀内 正久 鹿児島大学, 医歯学域医学系, 教授 (50264403)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | プロポフォール / L-カルニチン / 遊離脂肪酸 / ミトコンドリア / 脂肪酸代謝 / 糖代謝 / アミノ酸代謝 |
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| Outline of Final Research Achievements |
FFA increased in Group P and gradually decreased in Group P + C. There were significant differences between the two groups at the three-hour point (Group P; 331.2 ± 64.5 vs. Group P + C; 199 ± 73.6 ). Glucose decreased in groups (Group P; 53.8 ±16.6 mg/dL vs. Group P + C; 88 ± 11.3 mg/dL) at the three-hour point. Amino acid concentrations were higher in Group P + C compared with Group P after experiments; alanine and glutamine increased significantly. β-hydroxybutyric acid increased significantly in Group P + C, and intrahepatic triglyceride decreased in Group P + C. Dependency on fatty acid metabolism significantly decreased with propofol only; addition of L-carnitine prevented these effects.
Conclusions Propofol impaired mitochondrial fatty acid metabolism, which was compensated mainly by a switch to glucose metabolism and partially by amino acid metabolism. Addition of L-carnitine may improve this imbalance of energy metabolism.
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Report
(4 results)
Research Products
(3 results)
