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Role of corticotropin-releasing factor on bladder function in rats with psychology stress

Research Project

Project/Area Number 15K15582
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionUniversity of Fukui

Principal Investigator

Yokoyama Osamu  福井大学, 学術研究院医学系部門, 教授 (90242552)

Co-Investigator(Kenkyū-buntansha) 伊藤 秀明  福井大学, 学術研究院医学系部門, 准教授 (00345620)
黒川 哲之  福井大学, 医学部, 助教 (70529346)
関 雅也  福井大学, 学術研究院医学系部門, 助教 (70572444)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords下部尿路機能障害 / ムスカリン受容体 / 心理ストレス / Corticotropin / 膀胱 / CRF / ラット / ストレス / CRF-R1 / 副腎皮質刺激ホルモン放出因子 / メタボリック症候群 / 炎症性サイトカイン
Outline of Final Research Achievements

Corticotropin-releasing factor (CRF) is one of the main factors of the hypothalamic-pituitary-adrenocortical axis and known as stress-related peptide. As well as the nervous systems, the CRF and CRF-related peptides are distributed in the peripheral viscera such as bladder. In the present study, we investigated the contribution of psychological stress and CRF on the bladder function in rats.The data showed mRNA overexpression of CRF-R1 and M3 muscarinic receptor of the bladder were recognized in rats receiving psychological stress. Psychological stress increased the response of muscarinic contraction of the bladder strips however, the increase was not antagonized by CRF-R1 antagonist antalarmin. CRF did not influence bladder contraction in itself. In contrast, when rats did not receive the psychological stress, no increase in muscarinic contraction was found. These results support the hypothesis that psychological stress reinforces M3 receptor-mediated contractions.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (36 results)

All 2017 2016 2015 Other

All Journal Article (18 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 14 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (17 results) (of which Int'l Joint Research: 11 results,  Invited: 5 results) Remarks (1 results)

  • [Journal Article] Nerve growth factor release from the urothelium increases via activation of bladder C-fiber in rats with cerebral infarction2017

    • Author(s)
      R.Yokokawa, H.Akino, H.Ito, X.Zha, O.Yokoyama
    • Journal Title

      Neurourol Urodyn

      Volume: 36 Issue: 6 Pages: 1448-1455

    • DOI

      10.1002/nau.23142

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Safety and efficacy of the combination of once-daily tadalafil and alpha-1 blocker in Japanese men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: A randomized, placebo-controlled, cross-over study2017

    • Author(s)
      M.Takeda, O.Yokoyama, M.Yoshida, O.Nishizawa, K.Hirata, R.Nakaoka, Y.Takita, M.Murakami
    • Journal Title

      Int J Urol

      Volume: 24 Issue: 7 Pages: 539-547

    • DOI

      10.1111/iju.13357

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Appearance of high endothelial venule-like vessels in benign prostatic hyperplasia is associated with lower urinary tract symptom2017

    • Author(s)
      Inamura S, Shinagawa T, Hoshino H, Sakai Y, Imamura Y, Yokoyama O, Kobayashi M
    • Journal Title

      Prostate

      Volume: 77 Issue: 7 Pages: 794-802

    • DOI

      10.1002/pros.23319

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nocturnal polyuria and hypertension in patients with lifestyle related diseases and overactive bladder2017

    • Author(s)
      O.Yokoyama, O.Nishizawa, Y.Homma, M.Takeda, M.Gotoh, H.Kakizaki, H.Akino, K.Hayashi, K.Yonemoto; OASIS project group
    • Journal Title

      J Urol

      Volume: 197 Issue: 2 Pages: 423-431

    • DOI

      10.1016/j.juro.2016.08.087

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological implications to micropapillary bladder urothelial carcinoma of the presence of sialyl Lewis X-decorated mucin 1 in stroma-facing membranes.2017

    • Author(s)
      8.Shinagawa T, Hoshino H, Taga M, Sakai Y, Imamura Y, Yokoyama O, Kobayashi M.
    • Journal Title

      Urol Oncol.

      Volume: 17 Pages: 1078-1439

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cost-Effectiveness Analysis of Long-Term Intermittent Self-Catheterization with Hydrophilic-Coated and Uncoated Catheters in Patients with Spinal Cord Injury in Japan.2017

    • Author(s)
      6.Watanabe T, Yamamoto S, Gotoh M, Saitoh T, Yokoyama O, Murata T, Takeda M.
    • Journal Title

      Low Urin Tract Symptoms

      Volume: 9 Issue: 3 Pages: 142-150

    • DOI

      10.1111/luts.12122

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical guidelines for male lower urinary tract symptoms and benign prostatic hyperplasia.2017

    • Author(s)
      7.Homma Y, Gotoh M, Kawauchi A, Kojima Y, Masumori N, Nagai A, Saitoh T, Sakai H, Takahashi S, Ukimura O, Yamanishi T, Yokoyama O, Yoshida M, Maeda K.
    • Journal Title

      Int J Urol

      Volume: 24 Pages: 716-729

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 下部尿路症状とメタボリック症候群2017

    • Author(s)
      青木 芳隆, 岡田 昌裕, 横山 修
    • Journal Title

      泌尿器外科

      Volume: 30 Pages: 143-147

    • Related Report
      2016 Research-status Report
  • [Journal Article] 男性下部尿路症状とメタボリック症候群2017

    • Author(s)
      横山 修, 伊藤 秀明, 青木 芳隆, 松田 陽介, 福島 正人
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 5 Pages: 140-144

    • Related Report
      2016 Research-status Report
  • [Journal Article] α1D-adrenoceptor blockade increases voiding efficiency by improving external urethral sphincter activity in rats with spinal cord injury2016

    • Author(s)
      H.Ishida, H.Yamauchi, H.Ito, H.Akino, O.Yokoyama
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 311 Issue: 5 Pages: R971-R978

    • DOI

      10.1152/ajpregu.00030.2016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 特集に寄せて 生活習慣病と下部尿路症状2016

    • Author(s)
      横山 修
    • Journal Title

      排尿障害プラクティス

      Volume: 24 Pages: 13-13

    • Related Report
      2016 Research-status Report
  • [Journal Article] 過活動膀胱とは-定義と発症のメカニズム-2016

    • Author(s)
      横山 修
    • Journal Title

      カレントテラピー

      Volume: 34 Pages: 8-13

    • Related Report
      2016 Research-status Report
  • [Journal Article] Tadalafil 5mg once daily for the treatment of Asian men with lower urinary tract symptoms secondary to benign prostatic hyperplasia: Analyses of data pooled from three randomized, double-blind, placebo-controlled studies2015

    • Author(s)
      Nishizawa O, Yoshida M, Takeda M, Yokoyama O, Morisaki Y, Murakami M, Viktrup Lars.
    • Journal Title

      INTERNATIONAL JOURNAL OF UROLOGY

      Volume: 22 Issue: 4 Pages: 378-384

    • DOI

      10.1111/iju.12699

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Once-daily oxybutynin patch improves nocturia and sleep quality in Japanese patients with overactive bladder: Post-hoc analysis of a phaseIII randomized clinical trial2015

    • Author(s)
      Yokoyama O, Yamaguchi A, Yoshida M, Yamanishi T, Ishizuka O, Seki N, Takahashi S, Yamaguchi O, Higo N, Minami H, Masegi Y.
    • Journal Title

      INTERNATIONAL JOURNAL OF UROLOGY

      Volume: 22 Issue: 7 Pages: 684-688

    • DOI

      10.1111/iju.12755

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tadalafil for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a review of clinical data in Asian men and an update on the mechanism of action2015

    • Author(s)
      O.Yokoyama,Y.Igawa,M.Takeda,T.Yamaguchi,M.Murakami,L.Viktrup
    • Journal Title

      Ther Adv Urol

      Volume: 7 Issue: 5 Pages: 249-264

    • DOI

      10.1177/1756287215589238

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety and efficacy of mirabegron as 'add-on' therapy in patients with overactive bladder treated with solifenacin: a post-marketing, open-label study in Japan (MILAI study)2015

    • Author(s)
      Yamaguchi O, Kakizaki H, Homma Y, Igawa Y, Takeda M, Nishizawa O, Gotoh M, Yoshida M, Yokoyama O, Seki N, Okitsu A, Hamada T, Kobayashi A, Kuroishi K
    • Journal Title

      BJU INTERNATIONAL

      Volume: 116 Issue: 4 Pages: 612-622

    • DOI

      10.1111/bju.13068

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Underlying mechanisms of urine storage dysfunction in rats with salt-loading hypertension2015

    • Author(s)
      Kurokawa T, Zha X, Ito H, Aoki Y, Akino H, Kobayashi M, Yokoyama O
    • Journal Title

      Life Sci

      Volume: 141 Pages: 8-12

    • DOI

      10.1016/j.lfs.2015.09.010

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical Guideline for Female Lower Urinary Tract Symptoms.2015

    • Author(s)
      Takahashi S, Takei M, Nishizawa O, Yamaguchi O, Kato K, Gotoh M, Yoshimura Y, Takeyama M, Ozawa H, Shimada M, Yamanishi T, Yoshida M, Tomoe H, Yokoyama O, Koyama M.
    • Journal Title

      Low Urin Tract Symptoms.

      Volume: 8 Issue: 1 Pages: 5-29

    • DOI

      10.1111/luts.12111

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Night-time frequency deteriorate sleep and quality of life: an analysis of international prostate symptom score and sleep questionnaire2017

    • Author(s)
      Y.Matsuta, Y.Aoki, H.Ito, O.Yokoyama
    • Organizer
      International Continence Society 47th Annual Meeting(ICS2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pharmacological treatment of urinary incontinence in Japan2017

    • Author(s)
      O.Yokoyama
    • Organizer
      2017 TUA Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Night-time frequency deteriorate sleep and quality of life: an analysis of international prostate symptom score and sleep questionnaire2017

    • Author(s)
      S.Inamura, T.Shinagawa, H.Hoshino, Y.Sakai, Y.Imamura, O.Yokoyama, M.Kobayashi
    • Organizer
      International Continence Society 47th Annual Meeting(ICS2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of imidafenacin on urine production, voided volume, and hours of undisturbed sleep in overactive bladder patients with nocturnal polyuria; post hoc analysis of two clinical trials2017

    • Author(s)
      O.Yokoyama, M.Takeda, M.Gotoh, M.Yoshida, H.Kakizaki, S.Takahashi, N.Masumori
    • Organizer
      EAU2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between overactive bladder and metabolic syndrome: A cross-sectional study among Japanese men and women2017

    • Author(s)
      Y.Aoki, C.Matsumoto, Y.Matsuta, H.Ito, Y.Kusaka, O.Yokoyama
    • Organizer
      AUA Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Overactive bladder is related to sexual well-being in japanese women2017

    • Author(s)
      Y.Aoki, K.Sasaki, Y.Matsuta, H.Ito, C.Matsumoto, Y.Kusaka, O.Yokoyama
    • Organizer
      AUA Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between female overactive bladder and metabolic syndrome2017

    • Author(s)
      Y.Aoki, C.Matsumoto, M.Okada, Y.Matsuta, H.Ito, Y.Kusaka, O.Yokoyama
    • Organizer
      The 12th Pan-Pacific Continence Society (PPCS) Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Is overactive bladder another facet of the metabolic syndrome? : a cross-sectional study among japanese men and women2017

    • Author(s)
      Y.Aoki, M.Okada, Y.Matsuta, H.Ito, C.Matsumoto, Y.Kusaka, O.Yokoyama
    • Organizer
      International Continence Society 47th Annual Meeting(ICS2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Accuracy of bladder volume determination using a new portable handheld ultrasound bladder scanner: a prospective study of 34 consecutive inpatients2017

    • Author(s)
      Y.Aoki, E.Sasamura, C.Kimura, K.Fujita, A.Itoga, Y.Matsuta, H.Ito, O.Yokoyama
    • Organizer
      International Continence Society 47th Annual Meeting(ICS2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] State-of-the-art lecture 生活習慣病とLUTS2016

    • Author(s)
      横山 修
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Metabolic syndrome and BPH2016

    • Author(s)
      H.Ito
    • Organizer
      AUA Annual Meeting 2016
    • Place of Presentation
      San Diego(USA)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 生活習慣病からみた排尿障害治療Update2016

    • Author(s)
      横山 修
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Metabolic syndrome and LUTS - Osamu Yokoyama state of the art lecture2016

    • Author(s)
      O.Yokoyama
    • Organizer
      第46回国際禁制学会年次総会(ICS2016 TOKYO)
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 生活習慣病を考慮した排尿障害治療のupdate2016

    • Author(s)
      横山 修
    • Organizer
      第68回西日本泌尿器科学会総会
    • Place of Presentation
      海峡メッセ下関(山口県下関市)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 高血圧ラットにおける食塩摂取制限が膀胱機能に及ぼす影響に関する実験的研究2016

    • Author(s)
      黒川 哲之, 長瀬 桂子, 山内 寛喜, 松田 陽介, 青木 芳隆, 伊藤 秀明, 横山 修
    • Organizer
      第23回日本排尿機能学会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2016 Research-status Report
  • [Presentation] 心理ストレスと高血圧:なぜ下部尿路機能障害を起こすのか?-Corticotropin-releasing factor の果たす役割-2016

    • Author(s)
      関 雅也, 査 新民, 長瀬 桂子, 山内 寛喜, 松田 陽介, 青木 芳隆, 伊藤 秀明, 横山 修
    • Organizer
      第23回日本排尿機能学会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2016 Research-status Report
  • [Presentation] 生活習慣の乱れと下部尿路障害、その関係を紐解く2016

    • Author(s)
      横山 修
    • Organizer
      第23回日本排尿機能学会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Remarks] 福井大学研究者総覧

    • URL

      http://t-profile.ad.u-fukui.ac.jp/search/index.html

    • Related Report
      2016 Research-status Report 2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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