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Hydrogen sulfide has a role as an endogenous relaxation factor in the bladder and prostate of male rats

Research Project

Project/Area Number 15K15583
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionKochi University

Principal Investigator

Saito Motoaki  高知大学, 教育研究部医療学系基礎医学部門, 教授 (60273893)

Co-Investigator(Kenkyū-buntansha) 清水 孝洋  高知大学, 教育研究部医療学系基礎医学部門, 准教授 (00363276)
東 洋一郎  高知大学, 教育研究部医療学系基礎医学部門, 助教 (80380062)
清水 翔吾  高知大学, 教育研究部医療学系基礎医学部門, 助教 (90721853)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords硫化水素 / 膀胱 / 前立腺 / 弛緩 / 硫化水素合成酵素
Outline of Final Research Achievements

We found that: (1) MPST and CAT were detected in the bladder and prostate and CBS was only detected in the prostate. On the other hand, CSE and DAO were not detected in both tissues. Immunoreactvities of these enzymes were mainly detected in the urothelium and smooth muscle layer of the bladder, and in the prostate glandular epithelium. (2) H2S was detected in the bladder and prostate tissues. (3) NaHS dose-dependently induced relaxation of pre-contracted BL-D, BL-T, PR-D and PR-V strips. There were no significant differences of the EC50 values or maximal relaxation rate against the pre-contractions among any of these tissues. Intravesically instilled GYY4137 significantly prolonged intercontraction intervals compared to the vehicle-treated group, and showed, although non-significant, tendency to reduce maximal voiding pressurecompared to the vehicle-treated group.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015

All Presentation (7 results) (of which Int'l Joint Research: 3 results)

  • [Presentation] Hydrogen sulfide can be an endogenous relaxation factor in the rat bladder and prostate.2017

    • Author(s)
      Shimizu T, Zou S, Shimizu S, Higashi Y, Nakamura K, Aratake T, Yamamoto M, Hamada T, Nagao Y, Saito M.
    • Organizer
      ICS2017 (International Continence Society 47th Annual Meeting)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 硫化水素は膀胱および前立腺における内因性の弛緩因子である2017

    • Author(s)
      清水孝洋、Zou Suo、清水翔吾、東洋一郎、尾野秀彬、中村久美子、新武享朗、山本雅樹、濱田朋弥、長尾佳樹、齊藤源顕
    • Organizer
      第9回排尿障害モデル動物研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Endogenous hydrogen sulfide can function as a relaxation factor in the rat bladder and prostate2017

    • Author(s)
      Zou S, Shimizu T, Shimizu S, Higashi Y, Ono H, Nakamura K, Aratake T, Yamamoto M, Hamada T, Nagao Y, Saito M
    • Organizer
      第70回日本薬理学会西南部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Wistar雄性ラットにおける膀胱および前立腺に対する硫化水素の弛緩作用と硫化水素合成酵素の発現2016

    • Author(s)
      中村久美子
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 硫化水素によるラット膀胱および前立腺に対する弛緩作用と硫化水素産生酵素の発現分布2015

    • Author(s)
      中村久美子
    • Organizer
      第68回日本薬理学会西南部会
    • Place of Presentation
      海峡メッセ下関(山口県・下関市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
  • [Presentation] Endogenous hydrogen sulfide can function as a potent relaxing factor in the rat bladder and prostate2015

    • Author(s)
      清水孝洋
    • Organizer
      The 10th Pan-Pacific Continence Society Meeting
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hydrogen sulfide is a potent relaxing factor in the rat bladder and prostate2015

    • Author(s)
      清水孝洋
    • Organizer
      American Urological Association, 110th Annual Meeting
    • Place of Presentation
      New Orleans
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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