Research Project
Grant-in-Aid for Challenging Exploratory Research
This study presents the first-in-human results after a minimum of 3 months of follow-up for the first two patients implanted with Biotube. Biotubes were prepared with wall thickness of ca. 1mm by embedding of molds into patients abdominal subcutaneous pouches for 2 months. Two female patients had end-stage renal disease and had been receiving heamodialysis with a high probability of failure. The biotubes after stored for 1 day in a 70% alcohol solution were bypassed by end-to side anastomoses over venous stenosis region of an AV shunt. Palpable thrill and typical turbulent flow pattern by pulsed-wave Doppler were observed. Monthly angiography showed little change in the implanted grafts with no signs of dilation or stenosis with time points up to 3 months. Repeated puncture could be performed without grafts damage. This first human study successfully supported the concept of creating dialysis access from autologous connective tissue Biotube grown in patients subcutaneous pouches.
All 2017 2016 2015 Other
All Journal Article (5 results) (of which Int'l Joint Research: 3 results, Peer Reviewed: 5 results) Presentation (7 results) (of which Int'l Joint Research: 5 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)
J Artif Organs.
Volume: Sep;19(3) Issue: 3 Pages: 262-9
10.1007/s10047-016-0894-9
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED MATERIALS
Volume: 104 Issue: 7 Pages: 1-10
10.1002/jbm.b.33495
J Artif Organs
Volume: 19(4) Issue: 4 Pages: 357-363
10.1007/s10047-016-0909-6
Pediatric Cardiology and Cardiac Surgery
Volume: 32 Issue: 3 Pages: 199-207
10.9794/jspccs.32.199
130005157530
Volume: 19(1) Issue: 1 Pages: 54-61
10.1007/s10047-015-0859-4
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