Development of Shunt for blood dialysis based on in-body tissue architecture technology
Project/Area Number |
15K15590
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
Nakayama Yasuhide 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (50250262)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 人工血管 / 再生医療 / 透析 / シャント / バスキュラーアクセス / 移植・再生医療 |
Outline of Final Research Achievements |
This study presents the first-in-human results after a minimum of 3 months of follow-up for the first two patients implanted with Biotube. Biotubes were prepared with wall thickness of ca. 1mm by embedding of molds into patients abdominal subcutaneous pouches for 2 months. Two female patients had end-stage renal disease and had been receiving heamodialysis with a high probability of failure. The biotubes after stored for 1 day in a 70% alcohol solution were bypassed by end-to side anastomoses over venous stenosis region of an AV shunt. Palpable thrill and typical turbulent flow pattern by pulsed-wave Doppler were observed. Monthly angiography showed little change in the implanted grafts with no signs of dilation or stenosis with time points up to 3 months. Repeated puncture could be performed without grafts damage. This first human study successfully supported the concept of creating dialysis access from autologous connective tissue Biotube grown in patients subcutaneous pouches.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Development of in vivo tissue-engineered microvascular grafts with an ultra small diameter of 0.6 mm (MicroBiotubes): acute phase evaluation by optical coherence tomography and magnetic resonance angiography.2016
Author(s)
Ishii D, Enmi J, Moriwaki T, Ishibashi-Ueda H, Kobayashi M, Iwana S, Iida H, Satow T, Takahashi JC, Kurisu K, Nakayama Y.
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Journal Title
J Artif Organs.
Volume: Sep;19(3)
Issue: 3
Pages: 262-9
DOI
Related Report
Peer Reviewed
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