Development of the noninvasive nasal spray vaccine for prevention of cervical cancer using the next generation type virus vector.
Project/Area Number |
15K15605
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | Mie University |
Principal Investigator |
Kawano Mitsuo 三重大学, 医学系研究科, 講師 (00234097)
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Co-Investigator(Kenkyū-buntansha) |
田畑 務 三重大学, 医学系研究科, 准教授 (40252358)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 子宮頸癌予防ワクチン / 子宮頸癌治療ワクチン / 次世代型ワクチン / 非侵襲性ワクチン / 粘膜免疫 / 腫瘍免疫 / PIV2 / HPV / 子宮頸癌 / 弱毒生ワクチン / 液性免疫 / 細胞性免疫 / 非侵襲性 / 経鼻投与 |
Outline of Final Research Achievements |
Human papillomaviruses (HPV) are known as a causative factor of cervical cancer. We confirm the efficacy of the HPV vaccines now in use in the world. However, positive action of HPV vaccination is temporarily stopped by side effects of those vaccinations in Japan. In this study, to develop effective HPV vaccines with no side effects we have constructed replication-deficient hPIV2 vector introduced HPV-L2 or -E7 gene and investigated the protective effects of the HPV vaccines by intranasal administration to mice.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Restrictive interleukin-10 induction by an innocuous Parainfluenza virus vector ameliorates nasal allergy.2017
Author(s)
Yamanaka K, Nakanishi T, Isono K, Hasegawa C, Inada Y, Mizutani K, Matsushima Y, Okada K, Mabuchi T, Kondo M, Yamagiwa A, Kakeda M, Habe K, Nosaka T, Gabazza EC, Yamazaki H, Mizutani H, Kawano M.
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Journal Title
J Allergy Clin Immunol
Volume: 139
Issue: 2
Pages: 682-686
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Phase II study of concurrent chemoradiotherapy with weekly cisplatin and paclitaxel in patients with locally advanced uterine cervical cancer: The JACCRO GY-01 trial.2016
Author(s)
Umayahara K, Takekuma M, Hirashima Y, Noda SE, Ohno T, Miyagi E, Hirahara F, Hirata E, Kondo E, Tabata T, Nagai Y, Aoki Y, Wakatsuki M, Takeuchi M, Toita T, Takeshima N, Takizawa K.
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Journal Title
Gynecol Oncol.
Volume: 140
Issue: 2
Pages: 253-258
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Inducible bronchus-associated lymphoid tissue plays an important role in the induction of antigen-specific immune response by Ag85B-hPIV2-based anti-tuberculosis vaccine in mice2016
Author(s)
Takahiro Nagatake, Yasuko Wada, Naomi Matsumoto, Michiko Shimojou, Soichiro Hirata, Ayaka Nasu, Hidehiko Suzuki, Koji Hosomi, Kentaro Ogami, Yusuke Tsujimura, Mitsuo Kawano, Tetsuya Nosaka, Yasuhiro Yasutomi and Jun Kunisawa
Organizer
AAI annual meeting 2016
Place of Presentation
Seattle (USA)
Year and Date
2016-05-13
Related Report
Int'l Joint Research
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