| Project/Area Number |
15K15618
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
森倉 一朗 島根大学, 医学部, 講師 (00362939)
飯笹 久 島根大学, 医学部, 准教授 (80306662)
青井 典明 島根大学, 医学部, 准教授 (80452556)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アレルギー性鼻炎 / スギ花粉症 / 舌下免疫療法 / 経口免疫療法 / 調節性T細胞 / スギ花粉症治療米 / protein body / 免疫学的寛容 / 調整性Ｔ細胞 / Ｔ細胞エピトープ / 経口免疫 / 花粉症治療米 |
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| Outline of Final Research Achievements |
we examined whether mucosal route of immunizations with Transgenic rice(Tg-rice) containing hyporeactive whole T-cell epitopes of Cryj1 and Cryj2, can actually attenuate nasalsymptoms in a murine model of cedar pollinosis. As results, sublingual administration or natural feeding of Tg-rice was able to attenuates nasal symptoms at the induction and eliciting phase as well. Furthermore eosinophil infiltration was less in those mice, and antigen-specific Th2 responses(I-5, IL-13 production) of cervical lymph node lymphocytes was significantly downregulated with regulatory T cell induction. Purified protein body fraction more efficiently attenuated nasal symptoms with less amount rather than transgenic rice itself.
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