Creating eyeball bio-batteries and challenging to suppress local active oxygen
| Project/Area Number |
15K15626
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Tohoku University |
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Principal Investigator |
Abe Toshiaki 東北大学, 医学系研究科, 教授 (90191858)
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| Co-Investigator(Kenkyū-buntansha) |
梶 弘和 東北大学, 工学研究科, 准教授 (70431525)
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| Co-Investigator(Renkei-kenkyūsha) |
Nishizawa Matsuhiko 東北大学, 大学院工学系研究科, 教授 (20273592)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 網膜色素上皮細胞 / マイクロ流路 / 活性酸素 / 低酸素 / ＶＥＧＦ |
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| Outline of Final Research Achievements |
We investigated the feasibility of the production of bio-batteries using micro-channel or eye ball by measuring active oxygen. It was possible to fabricate a porous polydimethylsiloxane (PDMS) film having an array of 10 micron pores and a PDMS mold having a flow path structure and culture retinal pigment epithelial cells (ARPE) in FY2015. In FY 2016, we could co-cultivate ARPE with HUVEC and found HUVEC migrate to the ARPE side, especially in some stress conditions. It turned out the possibility that mitochondria was involved in cultured cell death. Since the change in the generation of active oxygen was seen in mitochondria, we think there is a possibility to create the bio-battery, our final objective of production.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Long-term Protection of Genetically-Ablated Rabbit Retinal Degeneration by Sustained Transscleral Unoprostone Delivery2017
Author(s)
Nobuhiro Nagai, Eri Koyanagi, Yasuko Izumida, Junjun Liu, Aya Katsuyama, Hirokazu Kaji, Matsuhiko Nishizawa, Noriko Osumi, Mineo Kondo, Hiroko Terasaki, Yukihiko Mashima, Toru Nakazawa, Toshiaki Abe
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Journal Title
Investigative Ophthalmology & Visual Science
Volume: 57(15)
Issue: 15
Pages: 6527-6538
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 自己展開型薬剤徐放シートの網膜疾患治療への応用2016
Author(s)
近藤太郎, Zhaleh Kashkouli Nezhad, 陳俐君, 鈴木 仁, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
Organizer
日本バイオマテリアル学会シンポジウム2016
Place of Presentation
福岡国際会議場（福岡）
Year and Date
2016-11-21
Related Report
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[Presentation] 自己展開型薬剤徐放シートの眼科領域への応用2016
Author(s)
近藤太郎, Zhaleh Kashkouli Nezhad, 陳俐君, 鈴木 仁, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
Organizer
第32回日本DDS学会学術集会
Place of Presentation
静岡県コンベンションアーツセンター（静岡）
Year and Date
2016-06-30
Related Report
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[Presentation] Protective Effects of Sustained Unoprostone Release Device in Rhodopsin Pro347Leu Transgenic Rabbits2016
Author(s)
Nobuhiro Nagai, Yasuko Izumida, Hirokazu Kaji, Matsuhiko Nishizawa, Aya Katsuyama, Shinji Yamada, Toru Nakazawa, Mineo Kondo, Hiroko Terasaki, Yukihiko Mashima, and Toshiaki Abe
Organizer
2016 ARVO Annual Meeting
Place of Presentation
Seattle, Washington
Year and Date
2016-05-01
Related Report
Int'l Joint Research
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[Presentation] Pharmacokinetic and Safety Evaluation of a Transscleral Sustained Unoprostone Release Device2015
Author(s)
Nobuhiro Nagai, Yasuko Izumida, Eri Koyanagi, Hirokazu Kaji, Matsuhiko Nishizawa, Takahito Imagawa, Akiko Morikawa, Toru Nakazawa, Yukihiko Mashima, and Toshiaki Abe
Organizer
ARVO2015
Place of Presentation
Denver, United States
Year and Date
2015-05-03
Related Report
Int'l Joint Research
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