| Project/Area Number |
15K15627
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUJII Teruo 東京大学, 生産技術研究所, 教授 (30251474)
ASAOKA Ryo 東京大学, 医学部附属病院, 特任講師 (00362202)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 緑内障 / インプラントデバイス / マイクロ流体 |
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| Outline of Final Research Achievements |
A new implant device available for glaucoma treatment was developed by using microfluidic technologies. This implant is called a microfluidic glaucoma drainage device (GDD), which has a flow channel and a passive micro-valve. The opening pressure of the micro-valve was measured to evaluate its pressure regulation performance. The results show that the pressure is regulated at low level enough to be available for glaucoma treatment.
An ex vivo test was also performed to verify the availability of the developed microfluidic GDD. A tip of the device was inserted into the anterior chamber of an eye taken from a slaughtered pig. The pressure in the eye was artificially elevated by injecting water into the eye from outside. We observed the outlet of the flow channel to detect liquid drainage and monitored the pressure. The result shows that the developed device provides a clinical-level ability in eye pressure regulation.
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