New clinical evidence for glaucoma surgery based on immunology

• Project/Area Number: 15K15630
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: University of Fukui
• Principal Investigator: Inatani Masaru 福井大学, 学術研究院医学系部門, 教授 (40335245)
• Co-Investigator(Renkei-kenkyūsha): TAKAMURA Yoshihiro 福井大学, 学術研究院医学系部門, 准教授 (00283193) ; TAKIHARA Yuji 福井大学, 医学部附属病院, 助教 (50640140) ; MIYAKE Seiji 福井大学, 学術研究院医学系部門, 助教 (50572765) ; MATSUMURA Takehiro 福井大学, 学術研究院医学系部門, 助教 (40529369)
• Research Collaborator: ARIMURA Shogo ; GOZAWA Makoto ; IWASAKI Kentaro
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 眼免疫学 / 緑内障

Outline of Final Research Achievements

Filtering surgery allows traffic between inside the eye and outside the eye, then, the blood-aqueous humor barrier breaks down. Therefore, we hypothesize that immune reaction would occur, then, further filtration surgery should result in surgical failure. Our studies revealed the following data. When a patient who had undergone successful trabeculectomy, the surgical outcome of the second trabeculectomy in the other eye is adversely affected by longer interval between the first and second trabeculectomies. The formation of the filtering bleb by tube shunt surgery is adversely affected by repeated intraocular surgeries.

Research Products

• [Journal Article] Comparison of subconjunctival scarring after microincision vitrectomy surgery using 20-, 23-, 25- and 27-gauge systems in rabbits. (2017)
  • Author(s): Gozawa M, Takamura Y, Miyake S, Iwasaki K, Arimura S, Takihara Y, Inatani M.
  • Journal Title: Acta Ophthalmol. Volume: 95 Issue: 7
  • DOI: 10.1111/aos.13459
  • Peer Reviewed / Open Access
• [Journal Article] Circumpapillary Retinal Nerve Fiber Layer Thickness, Anterior Lamina Cribrosa Depth, and Lamina Cribrosa Thickness in Neovascular Glaucoma Secondary to Proliferative Diabetic Retinopathy: a cross-sectional study. (2017)
  • Author(s): Yokota S, Takihara Y, Takamura Y, Inatani M
  • Journal Title: BMC Ophthalmology Volume: 17 Issue: 1 Pages: 57-57
  • DOI: 10.1186/s12886-017-0456-9
  • Peer Reviewed / Open Access
• [Journal Article] Panretinal Photocoagulation Using Short-Pulse Laser Induces Less Inflammation and Macular Thickening in Patients with Diabetic Retinopathy. (2017)
  • Author(s): Takamura Y, Arimura S, Miyake S, Matsumura T, Gozawa M, Iwasaki K, Inatani M.
  • Journal Title: J Ophthalmol. Volume: 2017 Pages: 8530261-8530261
  • DOI: 10.1155/2017/8530261
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of bleb fluid after Baerveldt glaucoma implantation using magnetic resonance imaging. (2017)
  • Author(s): Iwasaki K, Kanamoto M, Takihara Y, Arimura S, Takamura Y, Kimura H, Inatani M
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 11345-11345
  • DOI: 10.1038/s41598-017-11054-x
  • Peer Reviewed / Open Access
• [Journal Article] Photocoagulation of the Retinal Nonperfusion Area Prevents the Expression of the Vascular Endothelial Growth Factor in an Animal Model. (2017)
  • Author(s): Gozawa M, Takamura Y, Miyake S, Matsumura T, Morioka M, Yamada Y, Inatani M.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 58 Issue: 13 Pages: 5946-5953
  • DOI: 10.1167/iovs.17-22739
  • Peer Reviewed / Open Access
• [Journal Article] Randomized Clinical Trial for Early Postoperative Complications of Ex-PRESS Implantation versus Trabeculectomy: Complications Postoperatively of Ex-PRESS versus Trabeculectomy Study (CPETS) (2016)
  • Author(s): Arimura S, Takihara Y, Miyake S, Iwasaki K, Gozawa M, Matsumura T, Tomomatsu T, Takamura Y, Inatani M.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 26080-26080
  • DOI: 10.1038/srep26080
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The effect of triamcinolone acetonide or bevacizumab on the levels of proinflammatory cytokines after retinal laser photocoagulation in pigmented rabbits. (2016)
  • Author(s): Arimura S, Takamura Y, Miyake S, Gozawa M, Iwasaki K, Tomomatsu T, Matsumura T, Inatani M.
  • Journal Title: Experimental Eye Research Volume: 149 Pages: 1-7
  • DOI: 10.1016/j.exer.2016.06.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prospective observational study of conjunctival scarring after phacoemulsification. (2016)
  • Author(s): Gozawa M, Takamura Y, Miyake S, Yokota S, Sakashita M, Arimura S, Takihara Y, Inatani M.
  • Journal Title: Acta Ophthalmologica Volume: 94 Issue: 7
  • DOI: 10.1111/aos.13071
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comparing trabeculectomy outcomes between first and second operated eyes: A multicenter study. (2016)
  • Author(s): Iwasaki K, Takamura Y, Nishida T, Sawada A, Iwao K, Shinmura A, Kunimatsu-Sanuki S, Yamamoto T, Tanihara H, Sugiyama K, Nakazawa T, Inatani M.
  • Journal Title: PLOS ONE Volume: 11 Issue: 9 Pages: e0162569-e0162569
  • DOI: 10.1371/journal.pone.0162569
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Limbus- versus fornix-based trabeculectomy for open-angle glaucoma eyes with prior ocular surgery: the collaborative bleb-related infection incidence and treatment study. (2015)
  • Author(s): Yokota S
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 9290-9290
  • DOI: 10.1038/srep09290
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prospective observational study of conjunctival scarring after phacoemulsification. (2015)
  • Author(s): Gozawa M, Takamura Y, Miyake S, Yokota S, Sakashita M, Arimura S, Takihara Y, Inatani M
  • Journal Title: Acta Ophthalmologica Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Clinical evidence for the most effective filtering surgery. (2017)
  • Author(s): Inatani M
  • Organizer: the 58th annual meeting of the Ophthalmological Society of Taiwan
  • Int'l Joint Research / Invited
• [Presentation] Clinical evidence for the most effective filtering surgery. (2016)
  • Author(s): Inatani M
  • Organizer: 32th Korean Glaucoma Society
  • Place of Presentation: 韓国ソウル市JWマリオットホテル
  • Year and Date: 2016-11-18
  • Int'l Joint Research / Invited
• [Presentation] Surgical management of glaucoma patients with prior ocular surgery. (2015)
  • Author(s): Inatani M
  • Organizer: 2nd ASEAN Ophthalmology Society Congress
  • Place of Presentation: ベトナム ハノイ Lotte Hotel
  • Year and Date: 2015-10-29
  • Int'l Joint Research / Invited
• [Presentation] Wound healing and ocular inflammation in trabeculectomy. (2015)
  • Author(s): 稲谷 大
  • Organizer: 第69回日本臨床眼科学会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
  • Year and Date: 2015-10-22
  • Invited
• [Presentation] Which is better for IOP control in OAG eyes, limbus-based or fornix-based surgery? (2015)
  • Author(s): Inatani M
  • Organizer: 6th World Glaucoma Congress Hong Kong
  • Place of Presentation: 中国 香港 Convention center
  • Year and Date: 2015-06-06
  • Int'l Joint Research / Invited
• [Remarks] 福井大学眼科学教室 研究紹介
  • URL: http://ganka-fukuimed.jp/class/pages/kenkyu.html
• [Remarks] 福井大学眼科学教室
  • URL: http://www.med.u-fukui.ac.jp/GANKA/
• [Remarks] 福井大学眼科学教室
  • URL: http://ganka-fukuimed.jp