Regeneration of ciliary epithelium for ocular novel treatment.
| Project/Area Number |
15K15632
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
赤木 忠道 京都大学, 医学研究科, 講師 (30580112)
村上 智昭 京都大学, 医学研究科, 助教 (50549095)
宇治 彰人 京都大学, 医学研究科, 特定助教 (60534302)
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| Research Collaborator |
KITAOKA Takashi 長崎大学, 医歯薬学総合研究科, 教授
FUJIKAWA Azusa 長崎大学, 医歯薬学総合研究科, 講師
TSUIKI Eiko 長崎大学, 医歯薬学総合研究科, 講師
MATSUMOTO Makiko 長崎大学, 医歯薬学総合研究科, 助教
KINOSHITA Hirofumi 長崎大学, 医歯薬学総合研究科, 助教
MAEKAWA Yuki 長崎大学, 医歯薬学総合研究科, 助教
RYU Michi 長崎大学, 医歯薬学総合研究科, 大学院生
TAKAMI Yumiko 長崎大学, 医歯薬学総合研究科, 実験助手
HAMAGUCHI Sachiko 長崎大学, 医歯薬学総合研究科, 実験助手
TAKAHASHI Masayo 理化学研究所, チームリーダー
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | iPS細胞 / 毛様体 / 神経節細胞 |
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| Outline of Final Research Achievements |
Dr. Sasai established induce 3D retina from mice ES cells (Eiraku M, Nature 2011:472:51) & human ES cells (Nakano T, Cell Stem Cell 2012:10:771). We generated ciliary body from mice ES & iPS cells (Kinoshita H, Suzuma K, Kaneko J, Mandai M, Kitaoka T, Takahashi M: Induction of Functional 3D Ciliary Epithelium-Like Structure From Mouse Induced Pluripotent Stem Cells. Invest Ophthalmol Vis Sci 2016:57:153-161), and ganglion cells (Maekawa Y, Onishi A, Matsushita K, Koide N, Mandai M, Suzuma K, Kitaoka T, Kuwahara A, Ozone C, Nakano T, Eiraku M, Takahashi M: Optimized culture system to induce neurite outgrowth from retinal ganglion cells in three-dimensional retinal aggregates differentiated from mouse and human embryonic stem cells. Curr Eye Res 2016:41:558-568). These technique may be a breakthrough for novel ocular drag delivery systems.
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Report
(4 results)
Research Products
(2 results)
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[Journal Article] Optimized Culture System to Induce Neurite Outgrowth From Retinal Ganglion Cells in Three-Dimensional Retinal Aggregates Differentiated From Mouse and Human Embryonic Stem Cells.2016
Author(s)
Maekawa Y, Onishi A, Matsushita K, Koide N, Mandai M, Suzuma K, Kitaoka T, Kuwahara A, Ozone C, Nakano T, Eiraku M, Takahashi M
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Journal Title
Curr Eye Res
Volume: 19
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
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