| Project/Area Number |
15K15633
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto University |
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Principal Investigator |
Ikeda Hanako 京都大学, 医学(系)研究科(研究院), 准教授 (20372162)
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| Co-Investigator(Renkei-kenkyūsha) |
HATA Masayuki 京都大学, 大学院医学研究科, 助教 (70748269)
KAKIZUKA Akira 京都大学, 大学院生命科学研究科, 教授 (80204329)
HEIKE Toshio 京都大学, 大学院医学研究科, 教授 (90190173)
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| Project Period (FY) |
2015-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 神経保護 / 眼疾患 / 創薬 / スクリーニング / 眼難治疾患 |
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| Outline of Final Research Achievements |
We have shown that compounds which have inhibiting activity of VCP ATPase have neuroprotective effects. In this study, we explored new chemicals and found that several chemicals possessed cell protective effect. Moreover, we have developed screening systemes to test effectiveness of drugs in vitro. Using iPS cells from patients with ocular diseases, retinal cells with dysfunction similar to diseases could be prepared. These cells might be used for drug screening.
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