| Project/Area Number |
15K15637
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kagoshima University |
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Principal Investigator |
SAKAMOTO Taiji 鹿児島大学, 医歯学域医学系, 教授 (10235179)
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| Co-Investigator(Kenkyū-buntansha) |
園田 祥三 鹿児島大学, 医歯学域附属病院, 講師 (20325806)
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| Co-Investigator(Renkei-kenkyūsha) |
MARUYAMA Kazuo 帝京大学, 薬学部, 教授 (30130040)
TACHIBANA Katsurou 福岡大学, 医学部, 教授 (40271605)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 網膜 / サイトカイン / 眼球 / liposome / silicone / retinal detachment / ulctrasound / 薬物送達 / 乳酸 / 画像診断 / retina |
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| Outline of Final Research Achievements |
We succeeded in creating a permeability model using polar cells. This system proved that retinal pigment epithelium (RPE) cells acquire polar secretion ability of VEGF by having polarity. Next, we examined the mechanism of how drugs currently used clinically permeate RPE. As a prediction, a paracellular / intracellular pathway can be considered, but focusing on endocytosis, in particular via Fc receptor. By administering an endocytosis inhibiting drug, the permeability of the RPE layer of the anti-VEGF drug was suppressed. From this, it was possible to demonstrate the difference in clinical action of anti-VEGF drugs.
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