Study of ophthalmic theranostics
Project/Area Number |
15K15637
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Ophthalmology
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Research Institution | Kagoshima University |
Principal Investigator |
SAKAMOTO Taiji 鹿児島大学, 医歯学域医学系, 教授 (10235179)
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Co-Investigator(Kenkyū-buntansha) |
園田 祥三 鹿児島大学, 医歯学域附属病院, 講師 (20325806)
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Co-Investigator(Renkei-kenkyūsha) |
MARUYAMA Kazuo 帝京大学, 薬学部, 教授 (30130040)
TACHIBANA Katsurou 福岡大学, 医学部, 教授 (40271605)
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Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 網膜 / サイトカイン / 眼球 / liposome / silicone / retinal detachment / ulctrasound / 薬物送達 / 乳酸 / 画像診断 / retina |
Outline of Final Research Achievements |
We succeeded in creating a permeability model using polar cells. This system proved that retinal pigment epithelium (RPE) cells acquire polar secretion ability of VEGF by having polarity. Next, we examined the mechanism of how drugs currently used clinically permeate RPE. As a prediction, a paracellular / intracellular pathway can be considered, but focusing on endocytosis, in particular via Fc receptor. By administering an endocytosis inhibiting drug, the permeability of the RPE layer of the anti-VEGF drug was suppressed. From this, it was possible to demonstrate the difference in clinical action of anti-VEGF drugs.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Lens regeneration in children.2018
Author(s)
Vavvas DG, Dryja TP, Wilson ME, Olsen TW, Shah A, Jurkunas U, Pineda R, Poulaki V, Palioura S, Veldman P, Moreno-Montañés J, Pinazo-Duran MD, Pastor JC, Tsilimbaris M, Rhee D, Colby K, Hunter DG, Thanos S, Sakamoto T, Pasquale LR, Miller JW, VanderVeen D, Lambert SR.
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Journal Title
Nature
Volume: 未定
Issue: 7699
Pages: E2-E3
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Benefits of aflibercept treatment for age-related macular degeneration patients with good best-corrected visual acuity at baseline.2017
Author(s)
Minami S, Nagai N, Suzuki M, Kurihara T, Sonobe H, Kamoshita M, Uchida A, Shinoda H, Takagi H, Sonoda S, Sakamoto T, Tsubota K, Ozawa Y
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Journal Title
Sci Rep.
Volume: 8
Issue: 1
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] INCOMPLETE REPAIR OF RETINAL STRUCTURE AFTER VITRECTOMY WITH INTERNAL LIMITING MEMBRANE PEELING2016
Author(s)
Hisatomi T, Tachibana T, Notomi S, Nakatake S, Fujiwara K, Murakami Y, Ikeda Y, Yoshida S, Enaida H, Murata T, Sakamoto T, Sonoda KH, Ishibashi T.
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Journal Title
Retina
Volume: Epub ahead of print
Issue: 8
Pages: 0-0
DOI
Related Report
Peer Reviewed
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