The research on creation of new intestinal tract as a treatment for Hirschsprung disease and allied diseases

• Project/Area Number: 15K15645
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pediatric surgery
• Research Institution: Kyushu University
• Principal Investigator: Taguchi Tomoaki 九州大学, 医学研究院, 教授 (20197247)
• Co-Investigator(Kenkyū-buntansha): 黒田 達夫 慶應義塾大学, 医学部(信濃町), 教授 (60170130) ; 山座 孝義 九州大学, 歯学研究院, 准教授 (80304814) ; 柳 佑典 九州大学, 大学病院, 助教 (30596664) ; 松浦 俊治 九州大学, 医学研究院, 講師 (10532856) ; 吉丸 耕一朗 九州大学, 大学病院, 助教 (60711190)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: ヒルシュスプルング病 / 小児消化器疾患学 / 消化管神経節細胞 / 再生医療 / 指定難病 / ヒルシュスプルング病類縁疾患 / 組織工学

Outline of Final Research Achievements

Mouse-derived dental pulp stem cells (DPSC) were phenotypically and functionally evaluated by isolating and culturing the dental pulp from the teeth of C57Bl/ 6 mouse and allied disorders of Hirschsprung's disease (ADHD) model mouse. In addition, we studied the differentiation tendency in vivo using stem cells from human exfoliated deciduous teeth (SHED). In the ADHD model, body weight gain was observed in the SHED-transplanted group as compared with non-transplanted group. This finding suggests that SHED differentiated in vivo into intestinal nervous system cells. The result of this research can be said to be a meaningful result for the preparation of intestinal tract using autologous cells.

Research Products

• [Journal Article] Regeneration of diaphragm with bio-3D cellular patch (2018)
  • Author(s): Zhang Xiu-Ying、Yanagi Yusuke、Sheng Zijing、Nagata Kouji、Nakayama Koichi、Taguchi Tomoaki
  • Journal Title: Biomaterials Volume: 167 Pages: 1-14
  • DOI: 10.1016/j.biomaterials.2018.03.012
  • Peer Reviewed / Open Access
• [Journal Article] The incidence of chylous ascites after liver transplantation and the proposal of a diagnostic and management protocol (2018)
  • Author(s): Matsuura Toshiharu、Yanagi Yusuke、Hayashida Makoto、Takahashi Yoshiaki、Yoshimaru Koichiro、Taguchi Tomoaki
  • Journal Title: Journal of Pediatric Surgery Volume: 53 Issue: 4 Pages: 671-675
  • DOI: 10.1016/j.jpedsurg.2017.06.004
  • Peer Reviewed
• [Journal Article] 小児外科領域における新規治療の開発-難治性疾患に対する乳歯歯髄肝細胞を用いた新規治療- (2018)
  • Author(s): 285田口智章、吉丸耕一朗、栁佑典、松浦俊治
  • Journal Title: 第118回日本外科学会定期学術集会 Volume: 宿題報告 Pages: 61-70
• [Journal Article] Current status of Hirschsprung’s disease: based on a nationwide survey of Japan (2017)
  • Author(s): Taguchi Tomoaki、Obata Satoshi、Ieiri Satoshi
  • Journal Title: Pediatric Surgery International Volume: 33 Issue: 4 Pages: 497-504
  • DOI: 10.1007/s00383-016-4054-3
  • Peer Reviewed
• [Journal Article] The incidence and outcome of allied disorders of Hirschsprung's disease in Japan: Results from a nationwide survey. (2017)
  • Author(s): Taguchi T, Ieiri S, Miyoshi K, Kohashi K, Oda Y, Kubota A, Watanabe Y, Matsufuji H, Fukuzawa M, Tomomasa T
  • Journal Title: Asian Journal of Surgery Volume: 40(1) Issue: 1 Pages: 29-34
  • DOI: 10.1016/j.asjsur.2015.04.004
  • Peer Reviewed
• [Journal Article] Pediatric-onset Chronic Nonspecific Multiple Ulcers of Small Intestine (2017)
  • Author(s): Uchida Keiichi、Nakajima Atsushi、Ushijima Kosuke、Ida Shinobu、Seki Yoshitaka、Kakuta Fumihiko、Abukawa Daiki、Tsukahara Hisayuki、Maisawa Shun-ichi、Inoue Mikihiro、Araki Toshimitsu、Umeno Junji、Matsumoto Takayuki、Taguchi Tomoaki
  • Journal Title: Journal of Pediatric Gastroenterology and Nutrition Volume: 64 Issue: 4 Pages: 565-568
  • DOI: 10.1097/mpg.0000000000001321
  • Peer Reviewed
• [Journal Article] Mitochondria Regulate the Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth (2017)
  • Author(s): Kato H, Thi Mai Pham T, Yamaza H, Masuda K, Hirofuji Y, Han X, Sato H, Taguchi T, Nonaka K
  • Journal Title: Cell Structure and Function Volume: 42 Issue: 2 Pages: 105-116
  • DOI: 10.1247/csf.17012
  • NAID: 130005982848
  • ISSN: 0386-7196, 1347-3700
  • Peer Reviewed
• [Journal Article] Immunostaining for Hu C/D and CD56 is useful for a definitive histopathological diagnosis of congenital and acquired isolated hypoganglionosis (2017)
  • Author(s): Yoshimaru Koichiro、Taguchi Tomoaki、Obata Satoshi、Takemoto Junkichi、Takahashi Yoshiaki、Iwanaka Tsuyoshi、Yanagi Yusuke、Kuda Masaaki、Miyoshi Kina、Matsuura Toshiharu、Kinoshita Yoshiaki、Yoshioka Takako、Nakazawa Atsuko、Oda Yoshinao
  • Journal Title: Virchows Archiv Volume: 470 Issue: 6 Pages: 679-685
  • DOI: 10.1007/s00428-017-2128-9
  • Peer Reviewed
• [Journal Article] In vivo and ex vivo methods of growing a liver bud through tissue connection (2017)
  • Author(s): Yanagi Yusuke、Nakayama Koichi、Taguchi Tomoaki、Enosawa Shin、Tamura Tadashi、Yoshimaru Koichiro、Matsuura Toshiharu、Hayashida Makoto、Kohashi Kenichi、Oda Yoshinao、Yamaza Takayoshi、Kobayashi Eiji
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 14085-14085
  • DOI: 10.1038/s41598-017-14542-2
  • Peer Reviewed / Open Access
• [Journal Article] 乳歯幹細胞を用いた肝再生研究 (2017)
  • Author(s): 栁 佑典、山座孝義、山座治義、野中和明、中山功一、吉丸耕一朗、岩中 剛、高橋良彰、Rathi Yuniartha、松浦俊治、孝橋賢一、小田義直、大賀正一、絵野沢伸、小林英司、田口智章
  • Journal Title: 小児外科 Volume: 49 Pages: 567-571
• [Journal Article] 乳歯歯髄幹細胞を用いた腸管神経再生による先天性腸管蠕動不全に対する新規治療法の開発 (2017)
  • Author(s): 吉丸耕一朗、山座孝義、梶岡俊一、髙橋良彰、栁 佑典、小田義直、田口智章
  • Journal Title: 日本小児栄養消化器肝臓学会雑誌 Volume: 31 Pages: 84-84
• [Journal Article] ヒルシュスプルング病及びその類縁疾患に対する幹細胞を用いた新規治療法の展望 (2017)
  • Author(s): 吉丸耕一朗、山座孝義、近藤琢也、髙橋良彰、岩中 剛、Ratih Yuniartha、栁 佑典、小幡 聡、江角元史郎、伊崎智子、松浦俊治、木下義晶、田口智章
  • Journal Title: 小児外科 Volume: 49 Pages: 579-584
• [Journal Article] Massive pulmonary hemorrhage before living donor liver transplantation in infants (2016)
  • Author(s): Matsuura T, Yoshimaru K, Yanagi Y, Esumi G, Hayashida M, Taguchi T
  • Journal Title: Pediatr Transplant Volume: 20(1) Issue: 1 Pages: 89-95
  • DOI: 10.1111/petr.12650
  • Peer Reviewed
• [Journal Article] Surgical strategy according to the anatomical types of congenital portosystemic shunts in children (2016)
  • Author(s): Matsuura T, Takahashi Y, Yanagi Y, Yoshimaru K, Yamamura K, Morihana E, Nagata H, Uike K, Takada H, Taguchi T
  • Journal Title: J Pediatr Surg Volume: 51(12) Issue: 12 Pages: 2099-2104
  • DOI: 10.1016/j.jpedsurg.2016.09.046
  • Peer Reviewed
• [Journal Article] Insufficient portal vein inflow in children without major shunt vessels during living donor liver transplantation (2016)
  • Author(s): Matsuura T, Yoshimaru K, Yanagi Y, Esumi G, Hayashida M, Taguchi T
  • Journal Title: Ann Transplant Volume: 21 Pages: 373-379
  • Peer Reviewed
• [Journal Article] Virtually transparent surgical instruments in endoscopic surgery with augmentation of obscured regions (2016)
  • Author(s): Koreeda Y, Kobayashi Y, Ieiri S, Nishio Y, Kawamura K, Obata S, Souzaki R, Hashizume M, Fujie MG
  • Journal Title: Int J Comput Assist Radiol Surg Volume: - Issue: 10 Pages: 1927-1936
  • DOI: 10.1007/s11548-016-1384-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Bowel obstruction without history of laparotomy: Clinical analysis of 70 patients (2016)
  • Author(s): Yoshimaru K, Wada M, Esumi G, Takahashi Y, Yanagi Y, Hayashida M, Matsuura T, Ieiri S, Kinoshita Y, Taguchi T
  • Journal Title: Pediatr Int Volume: 58 Issue: 11 Pages: 1205-1210
  • DOI: 10.1111/ped.13003
  • Peer Reviewed / Open Access
• [Journal Article] 小児外科領域の臨床研究：難治性疾患からTRまで（第15回臨床研究セミナー 第3部外科臨床研究の実践） (2016)
  • Author(s): 田口智章
  • Journal Title: 日外会誌 Volume: 117(3) Pages: 236-238
• [Journal Article] 新生児生体肝移植の治療選択-産褥期生体ドナーの是非- (2016)
  • Author(s): 松浦俊治、髙橋良彰、吉丸耕一朗、栁 佑典、落合正行、日高庸博、加藤聖子、田口智章
  • Journal Title: 日本周産期・新生児医学会雑誌 Volume: 51(5) Pages: 1451-1454
• [Journal Article] Early jejunostomy creation in cases of isolated hypoganglionosis: verification of our own experience based on a national survey. (2015)
  • Author(s): Watanabe Y, Sumida W, Takasu H, Oshima K,Kanamori Y,Uchida K,Taguchi T.
  • Journal Title: Surg Today Volume: 45(12) Issue: 12 Pages: 1509-1512
  • DOI: 10.1007/s00595-015-1114-6
  • Peer Reviewed
• [Journal Article] Current clinical features in diagnosis and treatment for immaturity of ganglia in Japan: analysis from 10-year nationwide survey. (2015)
  • Author(s): Ieiri S, Miyoshi K, Nagata K, Miyata J, Kohashi K, Oda Y, Taguchi T.
  • Journal Title: Pediatr Surg Int Volume: 31(10) Issue: 10 Pages: 949-54
  • DOI: 10.1007/s00383-015-3774-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Outcome in VLBW infants with surgical intestinal disorder at 18 months of corrected age. (2015)
  • Author(s): Hayakawa M, Taguchi T, Urushihara N, Yokoi A, Take H, Shiraishi J, Fujinaga H, Ohashi K, Oshiro M, Kato Y, Ohfuji S, Okuyama H.
  • Journal Title: Pediatr Int Volume: 57(4) Issue: 4 Pages: 633-8
  • DOI: 10.1111/ped.12594
  • Peer Reviewed
• [Journal Article] In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice. (2015)
  • Author(s): Yamaza T, Alatas FS, Yuniartha R, Yamaza H, Fujiyoshi JK, Yanagi Y, Yoshimaru K, Hayashida M, Matsuura T, Aijima R, Ihara K, Ohga S, Shi S, Nonaka K, Taguchi T.
  • Journal Title: Stem Cell Res Ther Volume: 6(1) Issue: 1 Pages: 171-171
  • DOI: 10.1186/s13287-015-0154-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Segmental dilatation of the intestine: results of a nationwide survey in Japan. (2015)
  • Author(s): Sakaguchi T, Hamada Y, Masumoto K, Taguchi T; Japanese Study Group of Allied Disorders of Hirschsprung’s Disease.
  • Journal Title: Pediatr Surg Int Volume: 31(11) Issue: 11 Pages: 1073-6
  • DOI: 10.1007/s00383-015-3788-7
  • Peer Reviewed
• [Journal Article] Megacystis microcolon intestinal hypoperistalsis syndrome: A report of a nationwide survey in Japan (2015)
  • Author(s): Soh H, Fukuzawa M, Kubota A, Kawahara H, Ueno T, Taguchi T
  • Journal Title: Journal of Pediatric Surgery Volume: 50 Issue: 12 Pages: 2048-2050
  • DOI: 10.1016/j.jpedsurg.2015.08.026
  • Peer Reviewed
• [Journal Article] Reevaluation of acetylcholinesterase staining for the diagnosis of hirschsprung disease and allied disorders. (2015)
  • Author(s): Budianto IR, Obata S, Kinoshita Y, Yoshimaru K, Yanagi Y, Miyata J, Nagata K, Ieiri S, Taguchi T
  • Journal Title: J Pediatr Gastroenterol Nutr Volume: 60 Issue: 5 Pages: 606-12
  • DOI: 10.1097/mpg.0000000000000664
  • Peer Reviewed / Open Access
• [Presentation] Stem cell therapy for Pediatric Surgical diseases (2017)
  • Author(s): Taguchi T
  • Organizer: Pediatric Surgery Update Symposium
  • Place of Presentation: Chittagong, Bangladesh
  • Year and Date: 2017-03-31
  • Int'l Joint Research
• [Presentation] hypoganglionosis (2017)
  • Author(s): Taguchi T
  • Organizer: Pediatric Surgery Update Symposium
  • Place of Presentation: Chittagong, Bangladesh
  • Year and Date: 2017-03-31
  • Int'l Joint Research
• [Presentation] 成長ホルモン分泌不全性低身長症を合併した超短腸症候群症例の経験 (2017)
  • Author(s): 江角元史郎、三好きな、永田公二、伊崎智子、田口智章、大久保一宏、高田英俊、関口和人、井原健二
  • Organizer: 第32回日本静脈経腸栄養学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2017-02-23
• [Presentation] 新生児外科の進歩と新規治療の開発 (2017)
  • Author(s): 田口智章
  • Organizer: 鹿児島大学病院 成育診療リサーチセミナー
  • Invited
• [Presentation] Current status of intestinal transplantation in japan (2017)
  • Author(s): Matsuura T, Ueno T, Wada M, Hoshino K, Okajima H, Furukawa H, Taguchi T, Nishida S, Beduschi T, Vianna R
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 成人期に達したヒルシュスプルング病類縁疾患患者の検討 (2017)
  • Author(s): 江角元史郎，小幡聡，三好きな，吉丸耕一朗，宮田潤子，松浦俊治，伊崎智子，田口智章
  • Organizer: 第54回日本小児外科学会学術集会
• [Presentation] ヒルシュスプルング病の診断におけるAChE 染色とHE 染色の併用の有用性 (2017)
  • Author(s): 吉丸耕一朗，木下義晶，小幡聡，武本淳吉，髙橋良彰，岩中剛，栁佑典，三好きな，江角元史郎，宮田潤子，久田正昭，松浦俊治，考橋賢一，小田義直，田口智章
  • Organizer: 第54回日本小児外科学会学術集会
• [Presentation] The Operative Results For Consecutive 200 Cases Of Hirschsprung’S Disease With The Focus On Redo Surgery Based On Over Half Century Single Institution Experiences (2017)
  • Author(s): Ieiri S, Jimbo T, Obata S, Nagata K, Miyoshi K, Miyata J, Izaki T, Taguchi T
  • Organizer: Pediatric Colorectal Club 2017
  • Int'l Joint Research
• [Presentation] High Mortality Rate of Hirschsprung’s disease-related Short Bowel Syndrome ?Result from a Nationwide Survey in Japan- (2017)
  • Author(s): Taguchi T, Obata S, Akiyama T, Urushihara N, Kawahara H, Kubota M, Kono M, Nirasawa Y, Honda S, Nio M, Ieiri S
  • Organizer: PAPS 2017
  • Int'l Joint Research
• [Presentation] The Current Trend of Laparoscopy-assisted Operation for Hirschsprung’s disease in Japan (2017)
  • Author(s): Obata S, Ieiri S, Souzaki R, Akiyama T, Urushihara N, Kawahara H, Kubota M, Kono M, Nirakawa Y, Honda S, Nio M, Hashizume M, Taguchi T
  • Organizer: PAPS 2017
  • Int'l Joint Research
• [Presentation] ヒルシュスプルング病類縁疾患 (2017)
  • Author(s): 田口智章
  • Organizer: 第44回日本胆道閉鎖症研究会・第44回日本小児栄養消化器肝臓学会
  • Invited
• [Presentation] 乳歯歯髄幹細胞を用いた腸管神経再生による先天性腸管蠕動不全に対する新規治療法の開発 (2017)
  • Author(s): 吉丸耕一朗
  • Organizer: 第44回日本胆道閉鎖症研究会・第44回日本小児栄養消化器肝臓学会
• [Presentation] 小児生体肝移植におけるバックテーブル手術～肝静脈再建の工夫～ (2017)
  • Author(s): 髙橋良彰、松浦俊治、吉丸耕一朗、田口智章
  • Organizer: PSJM2016&秋季シンポジウム
• [Presentation] Hypoganglionosis におけるストーマ閉鎖術前評価の工夫－胃瘻ボタンを用いた疑似閉鎖 (2017)
  • Author(s): 伊崎智子、江角元史郎、三好きな、小幡聡、川久保尚徳、吉丸耕一朗、船津康孝、鴨打周、田口智章
  • Organizer: PSJM2017&秋季シンポジウム
• [Presentation] ヒルシュスプルング病類縁疾患に対する乳歯歯髄幹細胞を用いた腸管神経再生医療 (2017)
  • Author(s): 吉丸耕一朗、山座孝義、梶岡俊一、髙橋良彰、栁佑典、松浦俊治、小田義直、田口智章
  • Organizer: PSJM2018&秋季シンポジウム
• [Presentation] Experiences of Isolated hypoganglionosis(IH) in Kyushu University (2017)
  • Author(s): Izaki T, Esumi G, Yoshimaru K, Miyoshi K, Taguchi T
  • Organizer: CSPC
  • Int'l Joint Research
• [Presentation] Novel therapy for congenital refractory hypoperistalsis using mesenchymal stem cel (2017)
  • Author(s): 吉丸 耕一朗
  • Organizer: 台湾小児栄養消化器肝臓学会
  • Int'l Joint Research
• [Presentation] 新生児外科の最近の進歩と移植再生医療 (2017)
  • Author(s): 田口智章
  • Organizer: 総合周産期母子医療センターセミナー
  • Place of Presentation: 福岡
• [Presentation] 間葉系幹細胞を用いた先天性機能的腸管不全に対する新規治療の開発 (2017)
  • Author(s): 吉丸耕一朗、山座孝義、梶岡俊一、髙橋良彰、栁 佑典、松浦俊治、田口智章
  • Organizer: 第29回日本小腸移植研究会
  • Place of Presentation: 愛知
• [Presentation] Pediatric Liver Transplantation for Biliary Atresia (2016)
  • Author(s): Taguchi T, Mastuura T, Yoshimaru K,Takahashi Y
  • Organizer: 31st EPSA,IPEG Middle East Chapter
  • Place of Presentation: Cairo,Egypt
  • Year and Date: 2016-11-30
  • Int'l Joint Research
• [Presentation] New therapeutic proposal for Hirschsprung’s disease and allied disorders using the stem cells (2016)
  • Author(s): Yoshimaru K, Yamaza T, Kajioka S, Nakamura M, Takahashi Y, Yanagi Y, Matsuura T, Izaki T, Taguchi T
  • Organizer: Annual Conference of Cambodian Society of Surgery
  • Place of Presentation: Phnom Pehn, Cambodia
  • Year and Date: 2016-11-25
  • Int'l Joint Research
• [Presentation] 日本におけるヒルシュスプルング病の変遷-全国調査よりみえる変遷- (2016)
  • Author(s): 田口智章、小幡 聡、秋山卓士、漆原直人、本田昌平、川原央好、河野美幸、窪田正幸、韮澤融司、仁尾正紀、家入里志
  • Organizer: PSJM2016(第36回日本小児内視鏡外科・手術手技研究会)
  • Place of Presentation: 埼玉
  • Year and Date: 2016-10-27
• [Presentation] Current Profile of Hirschsprung’s Disease in Japan - A 5-year Nationwide Survey - (2016)
  • Author(s): Taguchi T, Obata S, JimboT, Ieiri S, Kubota M, Kono M, Nio M, Nirasawa Y, Honda S
  • Organizer: WOFAPS2016
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2016-10-08
  • Int'l Joint Research
• [Presentation] Bowel Perforation after Liver Transplantation for Biliary Atresia:A Retrospective Study for the Care of the Transition From Children to Adult (2016)
  • Author(s): Yanagi Y, Matsuura T, Hayashida M, Takahashi Y, Yoshimaru K, Esumi G, Taguchi T
  • Organizer: WOFAPS2016
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2016-10-08
  • Int'l Joint Research
• [Presentation] Rectal mucosal punch biopsy using K-PUNCH for the diagnosis of Hirschsprung’s disease:A thirty-year experience of 954 patients (2016)
  • Author(s): Yoshimaru K, Kinoshita Y, Yanagi Y, Obata S, Iwanaka T, Takahashi Y, Miyata J, Matsuura T, Taguchi T
  • Organizer: WOFAPS2016
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2016-10-08
  • Int'l Joint Research
• [Presentation] Hypoganlionosis (2016)
  • Author(s): Taguchi T
  • Organizer: IAPSCON 2016 AGRA
  • Place of Presentation: Taj Ganj, Agra, India
  • Year and Date: 2016-09-28
  • Int'l Joint Research
• [Presentation] 間葉系幹細胞を用いたヒルシュスプルング病類縁疾患に対する新規治療法の開発 (2016)
  • Author(s): 吉丸耕一朗、山座孝義、梶岡俊一、髙橋良彰、栁 佑典、松浦俊治、田口智章
  • Organizer: 第43回日本小児栄養消化器肝臓学会
  • Place of Presentation: 茨城
  • Year and Date: 2016-09-16
• [Presentation] ヒルシュスプルング病-40年間の全国調査よりみえる本邦での変遷­- (2016)
  • Author(s): 小幡 聡、田口智章、神保教広、家入里志
  • Organizer: 第5回日本小児診療多職種研究会
  • Place of Presentation: 神奈川
  • Year and Date: 2016-07-30
• [Presentation] 新生児肝臓移植の適応疾患 (2016)
  • Author(s): 松浦俊治、髙橋良彰、吉丸耕一朗、栁 佑典、田口智章
  • Organizer: 第52回日本周産期・新生児医学会学術集会
  • Place of Presentation: 富山
  • Year and Date: 2016-07-16
• [Presentation] 乳歯幹細胞を用いた肝再生医療 (2016)
  • Author(s): 栁 佑典、吉丸耕一朗、岩中 剛、髙橋良彰、松浦俊治、山座孝義、山座治義、野中和明、田口智章
  • Organizer: 第52回日本周産期・新生児医学会学術集会
  • Place of Presentation: 富山
  • Year and Date: 2016-07-16
• [Presentation] 肝オルガノイド移植 (2016)
  • Author(s): 栁 佑典、中山功一、小林英司、絵野沢伸、髙橋良彰、吉丸耕一朗、松浦俊治、田口智章
  • Organizer: 第34回日本肝移植研究会
  • Place of Presentation: 北海道
  • Year and Date: 2016-07-07
• [Presentation] EFFICACY OF HUC/D AND CD56 IMMUNOSTAINING AS STANDARD HISTOLOGICAL DIAGNOSTIC TOOL FOR CONGENITAL AND ACQUIRED HYPOGANGLIONOSIS (2016)
  • Author(s): Taguchi T, Yoshimaru K, Miyoshi K, Takahashi Y, Takemoto J, Iwanaka T, Obata S, Yanagi Y, Jimbo T, Kuda M, Kinoshita Y, Yoshioka T, Nakazawa A, Oda Y
  • Organizer: EUPSA2016
  • Place of Presentation: Milano, Italy
  • Year and Date: 2016-06-15
  • Int'l Joint Research
• [Presentation] 乳歯幹細胞を用いた肝再生医療研究 (2016)
  • Author(s): 栁 佑典、吉丸耕一朗、岩中 剛、高橋良彰、松浦俊治、山座孝義、山座治義、野中和明、田口智章
  • Organizer: 第53回日本小児外科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2016-05-24
• [Presentation] A 40-year Nationwide Survey of 4,939 patients of Hirschsprung’s Disease in Japan (2016)
  • Author(s): Taguchi T, Obata S, Jimbo T, Ieiri S, Nakame K, Akiyama T, Urushihara N, Kawahara H, Kubota M, Kono M, Nio M, Nirasawa Y, Honda S
  • Organizer: PAPS2016
  • Place of Presentation: Na Pali coast,Kauai,Hawaii
  • Year and Date: 2016-04-24
  • Int'l Joint Research
• [Presentation] Surgical strategy based on the anatomical types of congenital portosystemic shunts in children (2016)
  • Author(s): Matsuura T, Takahashi Y, Yoshimaru K, Yanagi Y, Taguchi T
  • Organizer: PAPS2016
  • Place of Presentation: Na Pali coast,Kauai,Hawaii
  • Year and Date: 2016-04-24
  • Int'l Joint Research
• [Presentation] Acquired Hypoganglionosis in Japan; Based on a Nationwide Survey in 10 Years (2016)
  • Author(s): Obata S, Ieiri S,Yamataka A, Koshinaga T, Iwai J, Ikeda H, Taguchi T
  • Organizer: PAPS2016
  • Place of Presentation: Na Pali coast,Kauai,Hawaii
  • Year and Date: 2016-04-24
  • Int'l Joint Research
• [Presentation] The role of splenectomy before liver transplantation in biliary atresia patients (2016)
  • Author(s): Takahashi Y, Matsuura T, Yoshimaru K, Yanagi Y, Taguchi T
  • Organizer: PAPS2016
  • Place of Presentation: Na Pali coast,Kauai,Hawaii
  • Year and Date: 2016-04-24
  • Int'l Joint Research
• [Presentation] 細胞の自己組織化を応用した3D プリンティング技術による肝組織構築 (2016)
  • Author(s): 栁 佑典、小林英司、中山功一、絵野沢伸、髙橋良彰、岩中 剛、吉丸耕一朗、松浦俊治、田口智章
  • Organizer: 第116 回日本外科学会定期学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2016-04-14
• [Presentation] 体性幹細胞を用いたヒルシュスプルング病とその類縁疾患の新規治療開発 (2016)
  • Author(s): 吉丸耕一朗、山座孝義、梶岡俊一、髙橋良彰、栁 佑典、松浦俊治、田口智章
  • Organizer: 第116 回日本外科学会定期学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2016-04-14
• [Presentation] Current Status and Progress of neonatal Surgery in Japan (2015)
  • Author(s): Taguchi T
  • Organizer: The 28th Annual Aurumn Meeting of The Korean Society of Perinatology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2015-12-05
  • Int'l Joint Research / Invited
• [Presentation] 短腸症候群に対する再生医療の研究 (2015)
  • Author(s): 田口智章
  • Organizer: 短腸症候群の会 第10回交流会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-29
• [Presentation] 小児外科領域の臨床研究：難治性疾患のTRを中心に (2015)
  • Author(s): 田口智章
  • Organizer: 日本臨床外科学会・日本外科学会共催 第15回臨床研究セミナー
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-28
• [Presentation] Current status of anorectal malformation of Kyushu University Group (2015)
  • Author(s): Taguchi T
  • Organizer: Annual Congress of Korean Surgical Society 2015
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2015-11-05
  • Int'l Joint Research / Invited
• [Presentation] Internal Anal Sphincter Achalasia -from a Nationwide Survey of Allied disorders of Hirschsprung’s Disease in Japan- (2015)
  • Author(s): Yoshimaru K
  • Organizer: 28th International Symposium on Pediatric Surgical Research
  • Place of Presentation: Dublin, Ireland
  • Year and Date: 2015-09-24
  • Int'l Joint Research
• [Presentation] Efficacy of the “K-PUNCH” method for rectal mucosal biopsy: A twenty-nine-year experience of 907 patients who underwent “K-PUNCH” biopsy- (2015)
  • Author(s): Yoshimaru K
  • Organizer: 28th International Symposium on Pediatric Surgical Research
  • Place of Presentation: Dublin, Ireland
  • Year and Date: 2015-09-24
  • Int'l Joint Research
• [Presentation] 新生児外科の進歩と明日からやるべきこと (2015)
  • Author(s): 田口智章
  • Organizer: 第51回日本周産期・新生児医学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-07-10
• [Presentation] Clinical characteristics of 77 intestinal obstruction cases requiring an operation without a history of laparotomy: A 10-year single-institute experience (2015)
  • Author(s): Yoshimaru K
  • Organizer: PAPS2015
  • Place of Presentation: Jeju,Korea
  • Year and Date: 2015-05-17
  • Int'l Joint Research
• [Presentation] Neonatal colonic perforation with congenital heart disease (2015)
  • Author(s): Kinoshita Y
  • Organizer: PAPS2015
  • Place of Presentation: Jeju,Korea
  • Year and Date: 2015-05-17
  • Int'l Joint Research
• [Book] Newborn Surgery 4th Edition (2017)
  • Author(s): Prem Puri
  • Total Pages: 1238
  • Publisher: CRC Press
  • ISBN: 9781482247701
• [Book] Operative General Surgery in neonates and Infants Springer Japan 2016 (2016)
  • Author(s): Taguchi T, Iwanaka T, Okamatsu T
  • Total Pages: 402
  • Publisher: Springer Japan 2016
• [Book] 小児科診療ガイドライン -最新の診療方針- (2016)
  • Author(s): 田口智章、吉丸耕一朗、小幡 聡
  • Total Pages: 670
  • Publisher: 株式会社 総合医学社
• [Book] 小児慢性特定疾病 診断の手引き (2016)
  • Author(s): 虫明聡太郎、鈴木光幸、中山佳子、疋田敏之、窪田正幸、新井勝大、小林一郎、工藤豊一郎、角田知之、十河 剛、佐々木英之、須磨崎亮、杉浦時雄、近藤宏樹、乾あやの、村上 潤、丸尾良浩、上野豪久、和田 基、家入里志、松藤 凡、福澤正洋、曺 英樹、田口智章、渡邉芳夫、黒田達夫
  • Total Pages: 980
  • Publisher: 株式会社 診断と治療社