| Project/Area Number |
15K15649
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
足立 孝二 筑波大学, 医学医療系, 講師 (70572569)
佐々木 薫 筑波大学, 医学医療系, 講師 (10536220)
木田 泰之 国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 研究グループ長 (20396526)
高山 祐三 国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 研究員 (60608438)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 末梢神経再生 / 人工神経 / 脂肪由来幹細胞 / 坐骨神経損傷モデル / 顔面神経不全麻痺モデル |
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| Outline of Final Research Achievements |
When patients injured peripheral nerve, nerve suture or transfer is performed now in operation rooms. But axon grows approximately 1 mm per day after surgeries, so we have to wait a lot of time to get injured nerve function recovered . Sekido has researched incomplete facial nerve palsy with murine model. Kida and Takayama have researched ways of direct reprogramming of stem cells to neural progenitor cells.
In this research, we tried to make artificial bundles of axon from neural progenitor cells. We have finally revealed how to induce neural progenitor cells effectively from murine stromal vascular fraction.
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