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Function of bone marrow derived stem cells in wound healing process

Research Project

Project/Area Number 15K15650
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Plastic surgery
Research InstitutionJichi Medical University

Principal Investigator

Yoshimura Kotaro  自治医科大学, 医学部, 教授 (60210762)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords再生医学 / 骨髄 / 幹細胞
Outline of Final Research Achievements

Ourin vivo experiment using fat grafting between GFP and wild type mice revelaed that most of regenerated adipocytes are from adipose resident stem cells, but a half of vascular endothelial cells are derive from bone marrow stem cells. Both stem cells collaborate in the wound healing process and execute their own roles contributing to the completion of healing and remodeling.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Differential contributions of graft- and host-derived cells in tissue regeneration/remodeling after fat grafting.2015

    • Author(s)
      Doi K, Ogata F, Eto H, Kato H, Kuno S, Kinoshita K, Kanayama K, Feng J, Manabe I, Yoshimura K
    • Journal Title

      Plastic and Reconstructive Surgery

      Volume: 135 Issue: 6 Pages: 1607-1617

    • DOI

      10.1097/prs.0000000000001292

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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