Function of bone marrow derived stem cells in wound healing process

Research Project

Project/Area Number	15K15650
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Plastic surgery
Research Institution	Jichi Medical University
Principal Investigator	Yoshimura Kotaro 自治医科大学, 医学部, 教授 (60210762)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords	再生医学 / 骨髄 / 幹細胞
Outline of Final Research Achievements	Ourin vivo experiment using fat grafting between GFP and wild type mice revelaed that most of regenerated adipocytes are from adipose resident stem cells, but a half of vascular endothelial cells are derive from bone marrow stem cells. Both stem cells collaborate in the wound healing process and execute their own roles contributing to the completion of healing and remodeling.