Development of a novel injectable bioabsorbable implant substituted by adipose tissue in vivo

• Project/Area Number: 15K15657
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Kansai Medical University
• Principal Investigator: MORIMOTO Naoki 関西医科大学, 医学部, 准教授 (40378641)
• Co-Investigator(Kenkyū-buntansha): 覚道 奈津子 関西医科大学, 医学部, 講師 (00509490) ; 伊藤 蘭 京都大学, 医学研究科, 特定病院助教 (00768921) ; 河合 勝也 京都大学, 医学研究科, 客員研究員 (90273458)
• Co-Investigator(Renkei-kenkyūsha): YAMAOKA Tetsuji (50243126)
• Research Collaborator: SAKAMOTO Yuki グンゼ株式会社, QOL研究所
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 吸収材料 / 脂肪 / 埋入

Outline of Final Research Achievements

We prepared the implants with collagen sponge (CS), using threads of either poly‐L‐lactide‐co‐ε‐caprolactone (PLACL) or poly‐L‐lactic acid (PLLA), and implanted them in the rat inguinal region.At 12 months after implantation, the internal space was maintained and the formation of adipose tissue was significantly promoted in the PLLA group.

Research Products

• [Journal Article] Development of a novel bioabsorbable implant that is substituted by adipose tissue in vivo. (2018)
  • Author(s): Ogino S, Morimoto N, Sakamoto M, Jinno C, Yoshikawa K, Enoshiri T, Sakamoto Y, Taira T, Suzuki S.
  • Journal Title: J Tissue Eng Regen Med Volume: 12 Issue: 3 Pages: 633-641
  • DOI: 10.1002/term.2482
  • Peer Reviewed
• [Presentation] 生体内で脂肪に置換される吸収材料の開発 (2017)
  • Author(s): 荻野秀一、森本尚樹、坂本道治、坂元悠紀、平嗣良、鈴木茂彦
  • Organizer: 第47回日本創傷治癒学会
• [Presentation] 生体で脂肪に置換される吸収性材料の開発 (2016)
  • Author(s): 荻野秀一 、森本尚樹 坂本道治 神野千鶴 坂元悠紀 鈴木茂彦
  • Organizer: 第25回日本形成外科学会基礎学術集会
  • Place of Presentation: 大阪（コングレコンベンションセンター）
  • Year and Date: 2016-09-15
• [Presentation] The development of a novel bioabsorbable implant that is substituted by adipose tissue in vivo (2016)
  • Author(s): Shuichi Ogino, Naoki Morimoto, Michiharu Sakamoto, Chizuru Jinno, Yuki Sakamoto, Tsuguyoshi Taira, Shigehiko Suzuki,
  • Organizer: the 2016 Tissue Engineering and Regenerative Medicine International Society- Asia Pacific Meeting
  • Place of Presentation: 台湾（台北市）
  • Year and Date: 2016-09-03
  • Int'l Joint Research