| Project/Area Number |
15K15674
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
前田 健康 新潟大学, 医歯学系, 教授 (40183941)
大峡 淳 新潟大学, 医歯学系, 教授 (40266169)
河野 芳朗 新潟大学, 医歯学系, 助教 (60303129)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 組織・細胞 / 歯学 / 口腔解剖 / 顎関節 / 細胞・組織 |
|---|
| Outline of Final Research Achievements |
Understanding the molecular mechanisms in regulating the temporomandibular joint (TMJ) development is essential for generating TMJ tissue engineering. However, even the phase and place of TMJ initiation that are necessary to analysis of molecular mechanisms are not established yet. We could define the suitable embryos in this study which were selected by their body weight, not by the fatal date. Runx2 and Sox9 were expressed in the presumptive region of the TMJ. Furthermore, 3D analysis for these gene expressions indicated that the condylar anlage was connected with the periosteum of the developing mandibular ramus. We also used organ culture techniques, but morphologically and genetically normal TMJ was not obtained by the modification of the ordinary methods. These results suggested that the completely new method of organ culture was required for the future study of TMJ tissue engineering.
|
