Development of DNA memory device using spacers in CRISPR
| Project/Area Number |
15K15675
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中川 一路 京都大学, 医学研究科, 教授 (70294113)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | CRISPR / レンサ球菌 / 比較ゲノム解析 / A群レンサ球菌 / 進化 / 多様化 / 病原細菌 |
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| Outline of Final Research Achievements |
In this study, we analyze fragment information (spacer sequence) contained in Clustered Regulatory Interspaced Short Palindromic Repeat (CRISPR) which is a memory region of foreign DNA existing in a non-gene region on the bacterial genome, and found a basis for development of a novel bacterial memory device. Especially when we examined the CRISPR region of group A streptococci and Streptococcus suis, although it is difficult to develop memory devices, CRISPR is highly accurate for strain typing and CRISPR also appears to be a mobile element in these bacterial species, which open new insights into this CRISPR research field.
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Report
(3 results)
Research Products
(6 results)
