Research Project
Grant-in-Aid for Challenging Exploratory Research
Although temporomandibular joint disease develops with various causes, common pathological findings are the overgrowth and activation of synovial cell. The E3 ubiquitin ligase Synoviolin / HRD1 involved in endoplasmic reticulum quality control has been identified as the cause of this synovial cell overgrowth. We have studied the mechanism of the endoplasmic reticulum quality control mechanism. Our results suggest that HRD1 is post-translationally modified by the ubiquitin-like protein NEDD8 and its activation is controlled by its neddylation. In this study, we clarified the mechanism of HRD1 activation by the post-translational modification. Our knowledge may shed light on the to the development of novel treatment for temporomandibular disorder.
All 2017 2016 2015
All Journal Article (4 results) (of which Int'l Joint Research: 3 results, Peer Reviewed: 4 results, Open Access: 3 results, Acknowledgement Compliant: 4 results) Presentation (5 results) (of which Int'l Joint Research: 2 results, Invited: 3 results)
Chromosome Research
Volume: 24 Issue: 2 Pages: 161-173
10.1007/s10577-015-9510-8
Neurobiol. Dis.
Volume: 82 Issue: 2 Pages: 478-486
10.1093/hmg/ddv467
Neurobiology of Disease
Volume: 82 Pages: 478-486
10.1016/j.nbd.2015.08.010
Biochem Biophys Res Commun. Nov 20;(3):509-13.
Volume: 467 Issue: 3 Pages: 509-513
10.1016/j.bbrc.2015.10.011
