Analysis of neuronal mechanisms underlying glossoptosis using arterially perfused decerebrate rats
| Project/Area Number |
15K15687
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
INOUE TOMIO 昭和大学, 歯学部, 教授 (70184760)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
中山 希世美 昭和大学, 歯学部, 講師 (00433798)
韓 仁陽 (清本聖文) 昭和大学, 歯学部, 助教 (00712556)
望月 文子 昭和大学, 歯学部, 助教 (10453648)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 舌筋 / 呼吸 / 動脈灌流標本 / 上気道開大筋 / 二酸化炭素負荷 / 腹直筋 / ソムノペンチル / プロポフォール / デクスメデトジン |
|---|
| Outline of Final Research Achievements |
Glossoptosis may cause obstructive ventilatory defects, such as obstructive sleep apnea syndrome; however, its etiology is not clear. In this study, we analyzed effects of hypercapnic acidosis on the respiratory motor nerve activity innervating the upper airway muscles using arterially perfused decerebrate rats. During hypercapnic acidosis (8% CO2), the peak amplitudes of the inspiratory discharges in the cervical spinal nerve innervating the infrahyoid muscles (CN), the hypoglossal nerve (HGN), the external branch of the superior laryngeal nerve (SLN), and the recurrent laryngeal nerve (RLN) were increased. Moreover, hypercapnic acidosis induced pre-inspiratory discharges in the CN, HGN, SLN, and RLN. These results suggest that the securing of the airway that occurs a certain time before dilation of the glottis may facilitate ventilation and improve hypercapnic acidosis. Glossoptosis may occur due to some defects of such regulation of upper airway muscle activity.
|
Report
(3 results)
Research Products
(48 results)
-
[Journal Article] Down-regulation of Irf8 by Lyz2-cre/loxP accelerates osteoclast differentiation in vitro2017
Author(s)
Saito E, Suzuki D, Kurotaki D, Mochizuki A, Manome Y, Suzawa T, Toyoshima Y, Ichikawa T, Funatsu T, Inoue T, Takami M, Tamura T, Inagaki K, and Kamijo R
-
Journal Title
Cytotechnology
Volume: 印刷中
Related Report
Peer Reviewed
-
-
-
[Journal Article] Effects of citalopram on jaw-closing muscle activity during sleep and wakefulness in mice2016
Author(s)
Ikawa Y, Mochizuki A, Katayama K, Kato T, Ikeda M, Abe Y, Nakamura S, Nakayama K, Wakabayashi N, Baba K, Inoue T
-
Journal Title
Neurosci Res
Volume: 113
Pages: 48-55
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] The effects of citalopram on masseter and neck muscle activities in mice2015
Author(s)
Nogawa Y, Mochizuki A, Katayama K, Ikeda M, Abe Y, Nakamura S, Nakayama K, Kiyomoto M, Kato T, Baba K, Wakabayashi N, Inoue T
Organizer
Society for Neuroscience 45th annual meeting
Place of Presentation
Chicago
Year and Date
2015-10-18
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
