| Project/Area Number |
15K15689
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
okabe koji 福岡歯科大学, 口腔歯学部, 教授 (80224046)
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| Co-Investigator(Kenkyū-buntansha) |
岡本 富士雄 福岡歯科大学, 口腔歯学部, 講師 (60153938)
福島 秀文 東北大学, 歯学研究科, 准教授 (70412624)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUSHITA Masayuki 琉球大学, 医学(系)研究科, 教授 (30273965)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | TRPM7 / 破骨細胞 / コンディショナルKOマウス / Mg2+代謝機構 / 加齢 |
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| Outline of Final Research Achievements |
We investigated Mg2+-metabolic mechanisms through the Channel-kinase TRPM7 which is a Mg2+-permeable cation channel in osteoclasts. Analyses of bone morphometry and serum Mg2+ concentration were performed using the osteoclast-specific TRPM7 conditional KO (cKO) mice and TRPM7-kinase mutant (KR) mice. There were no significant differences in bone morphometry parameters, serum Mg2+ concentration and bone resorption activity of cultivated osteoclast between cKO and KR and wild type mice of 8-week-old. On the other hand, 30-week-old cKO mice showed a significant increase in bone volume and decrease in the number of osteoclast. These findings suggest that Mg2+-permeable TRPM7 channel plays an important role in the bone resorption and bone remodeling by osteoclasts with aging.
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