Elucidation of Mg2+-metabolic mechanisms through the Channel-kinase TRPM7
Project/Area Number |
15K15689
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Functional basic dentistry
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Research Institution | Fukuoka Dental College |
Principal Investigator |
okabe koji 福岡歯科大学, 口腔歯学部, 教授 (80224046)
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Co-Investigator(Kenkyū-buntansha) |
岡本 富士雄 福岡歯科大学, 口腔歯学部, 講師 (60153938)
福島 秀文 東北大学, 歯学研究科, 准教授 (70412624)
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Co-Investigator(Renkei-kenkyūsha) |
MATSUSHITA Masayuki 琉球大学, 医学(系)研究科, 教授 (30273965)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | TRPM7 / 破骨細胞 / コンディショナルKOマウス / Mg2+代謝機構 / 加齢 |
Outline of Final Research Achievements |
We investigated Mg2+-metabolic mechanisms through the Channel-kinase TRPM7 which is a Mg2+-permeable cation channel in osteoclasts. Analyses of bone morphometry and serum Mg2+ concentration were performed using the osteoclast-specific TRPM7 conditional KO (cKO) mice and TRPM7-kinase mutant (KR) mice. There were no significant differences in bone morphometry parameters, serum Mg2+ concentration and bone resorption activity of cultivated osteoclast between cKO and KR and wild type mice of 8-week-old. On the other hand, 30-week-old cKO mice showed a significant increase in bone volume and decrease in the number of osteoclast. These findings suggest that Mg2+-permeable TRPM7 channel plays an important role in the bone resorption and bone remodeling by osteoclasts with aging.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.2017
Author(s)
Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W.
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Journal Title
Sci Signal.
Volume: 10(460)
Pages: eaah4117
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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