Development of a novel mouse model that recapitulates bone invasion of oral cancer

Research Project

Project/Area Number	15K15694
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Pathobiological dentistry/Dental radiology
Research Institution	Osaka University
Principal Investigator	Hata Kenji 大阪大学, 歯学研究科, 准教授 (80444496)
Co-Investigator(Renkei-kenkyūsha)	YONEDA Toshiyuki 大阪大学, 大学院歯学研究科, 招へい教員 (80142313)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	口腔がん / 骨浸潤
Outline of Final Research Achievements	Oral squamous cell carcinoma frequently invade the bone of mandible and maxilla and the bone invasion of oral cancer is a critical event that determines the patient poor prognosis. However, molecular mechanisms which regulate bone invasion are not fully understood. Here, we have established novel mouse model which recapitulates the bone invasion of oral squamous cell carcinoma. This model enables the dynamic imaging of bone invasion with high resolution. This mouse model will be a useful tool to understand the mechanism underlying bone invasion and contribute to the development therapeutic reagent for the treatment of bone invasion.