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Development of multifunctional restorative material including mineral inductive monomer

Research Project

Project/Area Number 15K15702
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

SAITO TAKASHI  北海道医療大学, 歯学部, 教授 (40265070)

Co-Investigator(Kenkyū-buntansha) 伊藤 修一  北海道医療大学, 歯学部, 准教授 (50382495)
永井 康彦  北海道医療大学, 歯学部, 助教 (60281284)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords象牙質 / 再石灰化 / 脱灰 / 石灰化誘導 / 象牙質再石灰化
Outline of Final Research Achievements

Mineral-inducing monomer blended prototype resin cement was bonded to non-demineralized tooth surface and demineralized tooth surface of human extracted dentine. The specimens were immersed in mineral solution for a short period and long term, and then were evaluated by morphological observation by SEM and crystallographic analysis by X-ray diffraction. Furthermore, the long term durability of the adhesive interface was investigated by evaluating adhesion. As a result, 5% and 10% monomers-added cement and 5% calcium chloride-added cement showed good remineralization inducing activity and good adhesion performance. It was also found that 35% HEMA treatment of calcium chloride enhances permeability of calcium ions into dentin.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (13 results)

All 2018 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (9 results)

  • [Journal Article] Demineralize prevention of dentin with fluoride varnish via automatic pH-cycling.2018

    • Author(s)
      Matsuda Y, Okuyama K, Yamamoto H, Tamaki Y, Saito T, Hayashi M, Satoh T, Koka M
    • Journal Title

      QST Takasaki Annual Report 2016

      Volume: M-8 Pages: 114-114

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Inhibition of Demineralization of Dentin by Fluoride-containing Desensitizers2017

    • Author(s)
      松田康裕,奥山克史,山本洋子,大木彩子,Khatun Morcheda Mosammat,佐野英彦,斎藤隆史
    • Journal Title

      The Japanese Journal of Conservative Dentistry

      Volume: 60 Issue: 6 Pages: 273-281

    • DOI

      10.11471/shikahozon.60.273

    • NAID

      130006304466

    • ISSN
      0387-2343, 2188-0808
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wear Characteristics and inhibition of enamael demineralization by resin-based coating materials.2017

    • Author(s)
      Kawamura N, Iijima M, Ito S, Brantley WA, Alpati SB, Muguruma T, Kawaguchi K, Saito T, Mizoguchi I
    • Journal Title

      Eur J Oral Sci

      Volume: 125 Issue: 2 Pages: 160-167

    • DOI

      10.1111/eos.12335

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effects of single application of pastes containing ion-releasing particles on enamel demineralization2017

    • Author(s)
      Iijima M, Kawaguchi K Kawamura N, Ito S, Saito T, Mizoguchi I
    • Journal Title

      Dental Materials Journal

      Volume: 36 Issue: 4 Pages: 461-468

    • DOI

      10.4012/dmj.2016-307

    • NAID

      130005865139

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ゲル状フッ化物含有知覚過敏抑制材料による象牙質再石灰化の検討.2017

    • Author(s)
      松田康裕,奥山克史,山本洋子,泉川昌宣,油井知雄,伊藤 修一,林美加子,斎藤隆史
    • Organizer
      第15回日本再生歯科医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フッ化物含有知覚過敏抑制剤によるエナメル質表面の脱灰抑制効果2017

    • Author(s)
      櫻井雅彦,松田康裕,奥山克史,山本洋子,カトゥーン モーサマット モーシーダ,佐野英彦,斎藤隆史
    • Organizer
      第147回日本歯科保存学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] S-PRGフィラーが象牙質コラーゲンへ与える影響2016

    • Author(s)
      伊藤修一、斎藤隆史
    • Organizer
      第2回生体機能性材料S-PRGフィラー研究会
    • Place of Presentation
      株式会社松風(京都市東山区)
    • Year and Date
      2016-12-10
    • Related Report
      2016 Research-status Report
  • [Presentation] 新規バイオアクティブセメントのイオン放出および生物学的性質の比較検討2016

    • Author(s)
      近藤有紀、伊藤修一、植原治、倉重圭史、斎藤隆史、齊藤正人
    • Organizer
      第144回日本歯科保存学会
    • Place of Presentation
      栃木県総合文化センター(栃木県宇都宮市)
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Presentation] ボンディング材における接着性モノマー添加による象牙質接着性に対する影響2016

    • Author(s)
      藤田裕介、伊藤修一、村井雄司、近藤有紀、斎藤隆史、齊藤正人
    • Organizer
      第54回日本小児歯科学会
    • Place of Presentation
      東京ドームホテル(東京都文京区)
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 新規バイオアクティブセメントのバイオフィルム形成抑制能および細胞増殖活性に対する影響2016

    • Author(s)
      近藤有紀、伊藤修一、佐藤夕紀、植原治、倉重圭史、斎藤隆史、齊藤正人
    • Organizer
      第54回日本小児歯科学会
    • Place of Presentation
      東京ドームホテル(東京都文京区)
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 機能性修復材料による象牙質石灰化研究2015

    • Author(s)
      伊藤修一
    • Organizer
      神奈川歯科大学研究談話会
    • Place of Presentation
      神奈川歯科大学(神奈川県横須賀市)
    • Year and Date
      2015-11-11
    • Related Report
      2015 Research-status Report
  • [Presentation] CO2レーザー照射とフッ化物塗布を併用したエナメル質の脱灰抑制2015

    • Author(s)
      飯嶋雅弘, 伊藤修一, 斎藤隆史, 溝口到
    • Organizer
      第27回日本レーザー歯学会
    • Place of Presentation
      北海道自治労会館(北海道、札幌市)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規バイオアクティブセメントの物理化学的特性について2015

    • Author(s)
      近藤有紀, 伊藤修一, 高田一江, 植原治, 倉重圭史, 斎藤隆史, 斎藤正人
    • Organizer
      第53回日本小児歯科学会
    • Place of Presentation
      広島国際会議場(広島県、広島市)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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