| Project/Area Number |
15K15705
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
江草 宏 東北大学, 歯学研究科, 教授 (30379078)
萱島 浩輝 大阪大学, 歯学研究科, 助教 (50632121)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 再生医療 / バイオロジー |
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| Outline of Final Research Achievements |
It was revealed that the PKC inhibitor (isoH-7) promotes osteogenic differentiation of iPS cells. We also examined the mold design of dome type titanium membrane using CAD / CAM, and fabricated the mold for vertical bone augmentation. Furthermore, iPS cell aggregates differentiated into osteoblasts by adding PKC inhibitor were transplanted into the back of mouse. As the result, tumor formation was confirmed, but the tumor size became smaller as compared with that induced without PKC inhibitor. It was suggested that by improving the protocol it could be a new bone formation methods using autologous iPS cells combined with the vertical bone augmentation mold.
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