| Project/Area Number |
15K15708
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Okayama University |
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Principal Investigator |
Kuboki Takuo 岡山大学, 医歯薬学総合研究科, 教授 (00225195)
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| Co-Investigator(Kenkyū-buntansha) |
大野 充昭 岡山大学, 医歯薬学総合研究科, 助教 (60613156)
前川 賢治 岡山大学, 医歯薬学総合研究科, 准教授 (20304313)
秋山 謙太郎 岡山大学, 大学病院, 講師 (70423291)
大島 正充 岡山大学, 医歯薬学総合研究科, 助教 (00548307)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アミノ酸 / 骨髄由来間葉系幹細胞 / アンチエイジング / 幹細胞 / 骨粗鬆症 / 創傷治癒 |
|---|
| Outline of Final Research Achievements |
Amino acids are essential for life and cell metabolism. We hypothesized that amino acids can regulate the stem cell phenotype and we performed a screening and found tryptophan as stemness regulator of BMSCs. Indeed, migration and colony forming ability of BMSCs was enhanced by tryptophan treatment. In vivo mice bone defect model, Tryptophan accelerated bone healing, and increased bone volume and trabecular number compared to PBS-injected group. In summary, L-tryptophan enhances the stemness and osteoblastic differentiation of BMSCs, and may be used as an essential factor to accelerate bone healing and/or prevent bone loss, such as in the case of ageing and osteoporosis.
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