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Idfentification of biomarkers for theprediction of oral frailty and Prosthodontic planning using the markers

Research Project

Project/Area Number 15K15709
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionThe University of Tokushima

Principal Investigator

ICHIKAWA Tetsuo  徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (90193432)

Co-Investigator(Kenkyū-buntansha) 誉田 栄一  徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (30192321)
矢儀 一智  徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (60456952)
南 憲一  徳島大学, 病院, 医員 (60732914)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsオーラルフレイル / フレイル / 食行動 / オトガイ舌骨筋 / 筋線維 / 生体インピーダンス / サルコペニア / 筋量 / 超音波
Outline of Final Research Achievements

The questionnaire analysis showed that scores of physical and oral frailty gradually increased with age; and the important age might be in the 50s-60s for oral frailty, and the assessment on “spilled food” and “eating difficulty” might be significant. The assessment of dietary recognition was consistent, and those of eating habits and eating action were improved after age 40. Geniohyoid muscle (GH) cross-sectional area (CSA)was significantly affected by age, gender, height, weight, tongue pressure, jaw-opening strength, swallowing sound duration, and GH velocity. GH CSA influenced swallowing and mastication. The bioimpedance analysis showed positive relationship between occlusal force and muscle volume of arms was found. A change to fast muscle was found in the no occlusal support group.
The above results suggested that the muscle volume would be a significant biomarker, whereas fast/ slow muscle and movement speed would not be significant contrary to the expectation.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (12 results)

  • [Journal Article] Changes in food bolus texture during mastication.2017

    • Author(s)
      Wada S, Goto T, Fujimoto K, Watanabe M, Nagao K, Nakamichi A, Ichikawa T.
    • Journal Title

      J Texture Studies

      Volume: 48 Issue: 2 Pages: 171-177

    • DOI

      10.1111/jtxs.12228

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Swallowing Sound: Preliminary Investigation of Normal Subjects.2016

    • Author(s)
      Honda T, Baba T, Fujimoto K, Goto T, Nagao K, Harada M, Honda E, Ichikawa T.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 12 Pages: e0168187-e0168187

    • DOI

      10.1371/journal.pone.0168187

    • NAID

      120006483295

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An innovative masticatory efficiency test using odour intensity in the mouth as a target marker: a feasibility study.2016

    • Author(s)
      Goto T, Higaki N, Yagi K, Ishida Y, Watanabe M, Nagao K, Ichikawa T.
    • Journal Title

      J Oral Rehabilitation

      Volume: 43 Issue: 12 Pages: 883-888

    • DOI

      10.1111/joor.12444

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Periodontal tactile input activates the prefrontal cortex.2016

    • Author(s)
      Higaki N, Goto T, Ichikawa T.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 36893-36893

    • DOI

      10.1038/srep36893

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 認知症患者の歯科治療に対する疑問と問題点 ―Clinical Question 調査から―2016

    • Author(s)
      服部 佳功, 枝広 あや子, 渡邊 裕, 平野 浩彦, 古屋 純一, 中島 純子, 田村 文誉, 北川 昇, 堀 一浩, 原 哲也, 吉川 峰加, 西 恭宏, 永尾 寛, 市川 哲雄, 櫻井 薫
    • Journal Title

      老年歯科医学

      Volume: 31 Pages: 3-8

    • NAID

      130005170837

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Swallowing sound waveform and its clinical significance: Evaluation using ultrasonography2015

    • Author(s)
      Tsuyoshi Honda, Takuro Baba, Keiko Fujimoto, Kan Nagao, Akira Takahashi, Tetsuo Ichikawa
    • Journal Title

      Journal of Oral Health and Biosciences

      Volume: 28 Pages: 21-27

    • NAID

      120005823520

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Fraitly and Oral Fraitly: Biomarker and Prosthodontic Strategy2017

    • Author(s)
      後藤崇晴 、市川哲雄
    • Organizer
      ADVANCED ON SEMINAR DIGITAL DENTISTRY JOINT MEETING TOKUSHIMA UNIVERSITY ALUMNAE ASSOCIATION- INDONESIA DENTAL ASSOCIATION
    • Place of Presentation
      Mataram(INDONESIA)
    • Year and Date
      2017-01-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] オーラルフレイルと食行動に関する実態調査2016

    • Author(s)
      岸本卓大、後藤崇晴、檜垣宜明、檜原 司、中道敦子、市川哲雄
    • Organizer
      日本咀嚼学会第27回学術大会
    • Place of Presentation
      広島大学(広島県・広島市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 咬合力維持における前頭前野の活動と感覚統合:インプラントと天然歯の比較2016

    • Author(s)
      檜垣宜明,後藤崇晴,岩脇有軌,石田雄一,渡邉 恵,友竹偉則,市川哲雄
    • Organizer
      日本口腔インプラント学会 第46回学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] オーラルフレイルとフレイルに関するアンケート調査:実態の把握2016

    • Author(s)
      檜原 司、後藤崇晴、今井守夫、多田 望、萬好哲也、井上三四郎、薦田淳司、佐藤修斎、堀内政信、宮本雅司、岡島雅代、市川哲雄
    • Organizer
      日本補綴歯科学会 九州支部,中国・四国支部合同学術大会
    • Place of Presentation
      熊本県歯科医師会館(熊本県・熊本市)
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 歯根膜からの感覚情報が前頭前野の活動に与える影響2016

    • Author(s)
      檜垣宜明,後藤崇晴,市川哲雄
    • Organizer
      日本補綴歯科学会 第125回学術大会2016.7.8-10,
    • Place of Presentation
      石川県立音楽堂(石川県・金沢市)
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔内のにおい強度に着目した新しい咀嚼能率測定方法の開発2016

    • Author(s)
      後藤崇晴,檜垣宜明,石田雄一,渡邉 恵,永尾 寛,市川哲雄
    • Organizer
      日本補綴歯科学会 第125回学術大会
    • Place of Presentation
      ANAクラウンプラザホテル金沢(石川県・金沢市)
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] オトガイ舌骨筋に着目した口腔機能低下予測因子の検討2016

    • Author(s)
      馬場拓朗、後藤崇晴、藤本けい子、本田 剛、永尾 寛、市川哲雄
    • Organizer
      日本老年歯科医学会第27回学術大会
    • Place of Presentation
      アスティとくしま(徳島県・徳島市)
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] オトガイ舌骨筋に着目した口腔機能低下予測因子の検討2016

    • Author(s)
      馬場拓朗、後藤崇晴、藤本けい子、本田 剛、永尾 寛、市川哲雄
    • Organizer
      一般社団法人日本老年歯科医学会第27回学術大会
    • Place of Presentation
      アスティとくしま、徳島県徳島市
    • Year and Date
      2016-06-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 一般青年の食行動と健康関連QOLおよび口腔関連QOLとの関連性の検討2015

    • Author(s)
      中村詩織、後藤崇晴、檜垣宜明、中道敦子、市川哲雄
    • Organizer
      特定非営利活動法人日本咀嚼学会第26回総会・学術大会
    • Place of Presentation
      鶴見大学会館、神奈川県横浜市
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 咀嚼回数と食塊物性との関連について2015

    • Author(s)
      檜垣宜明、後藤崇晴、中村詩織、中道敦子、市川哲雄
    • Organizer
      特定非営利活動法人日本咀嚼学会第26回総会・学術大会
    • Place of Presentation
      鶴見大学会館、神奈川県横浜市
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 閉塞性睡眠時無呼吸症候群患者の睡眠中の嚥下頻度の変化:下顎前方移動装置使用時と非使用時2015

    • Author(s)
      矢儀 一智、市川 哲雄
    • Organizer
      一般社団法人日本老年歯科医学会第26回学術大会
    • Place of Presentation
      パシフィコ横浜、神奈川県横浜市
    • Year and Date
      2015-06-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 嚥下音と嚥下動態の同時記録による嚥下音産生機序の解明2015

    • Author(s)
      本田 剛、藤本けい子、馬場拓朗、永尾 寛、市川哲雄
    • Organizer
      公益社団法人日本補綴歯科学会第124回学術大会
    • Place of Presentation
      大宮ソニックシティ、埼玉県さいたま市
    • Year and Date
      2015-05-30
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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