Development of bone augmentation using intermittent PTH administration without bone grafts
| Project/Area Number |
15K15711
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Nagasaki University |
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Principal Investigator |
SAWASE Takashi 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (80253681)
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| Co-Investigator(Kenkyū-buntansha) |
黒嶋 伸一郎 長崎大学, 病院(歯学系), 講師 (40443915)
佐々木 宗輝 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (10706336)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHISAKI Akira 岩手医科大学, 歯学部, 教授 (20356439)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | デンタルインプラント / PTH / 間歇的投与 / 持続的投与 / 骨量 / 骨質 / オッセオインテグレーション / PTH製剤 / 骨増生 / 顎骨 / 長管骨 / グラフトレス / ドラッグデリバリーシステム |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the effect of intermittent PTH administration on bone quality and quantity around implants in rat maxillae. Ovariectomized rats were used. Implants were placed at 3 weeks after tooth extraction of both maxillary first molars. Bone volume, osseointegration and bone quality around implants were analyzed at 3 and 5 weeks after intermittent PTH administrations. Intermittent PTH administrations significantly increased bone volume around implants and enhanced osseointegration as compared with saline group. Moreover, intermittent PTH injections significantly developed osteocyte network, and induced the preferential alignment of collagen/biological apatite c-axis. Combination therapy of PTH and mechanical load adapted bone quality around implants.
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Report
(3 results)
Research Products
(24 results)
