Strategy to control bone resorption around dental implants resorting to a criterion of pathological analysis of osteocytic ciliopathy
| Project/Area Number |
15K15713
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MASAKI CHIHIRO 九州歯科大学, 歯学部, 准教授 (60397940)
KONDO YUSUKE 九州歯科大学, 歯学部, 助教 (00611287)
MUKAIBO TARO 九州歯科大学, 歯学部, 助教 (50635117)
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| Co-Investigator(Renkei-kenkyūsha) |
TAMURA AKIKO 九州歯科大学, 歯学部附属病院, 医員 (30762067)
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| Project Period (FY) |
2015-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 歯科補綴学一般 / 歯科インプラント / 物理刺激 / 細胞分化 |
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| Outline of Final Research Achievements |
In this study, we tried to clarify osteocytic cilia related signaling by shutting out mechanical stimulation and to find out biomolecules concerning inhibitive control of bone resorption. IDG-SW3 cells were cultured and, taken into differentiating condition (Day0), fluorescent development of GFP, which is expressed in cooperation with Dmp1 expression and IDG-SW3 differentiation, was confirmed. Also, primary osteocytes were acquired from long bones of Dmp1-GFP transgenic mouse, and samples are being taken under analysis.
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Report
(2 results)
Research Products
(1 results)
