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Strategy to control bone resorption around dental implants resorting to a criterion of pathological analysis of osteocytic ciliopathy

Research Project

Project/Area Number 15K15713
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionKyushu Dental College

Principal Investigator

Hosokawa Ryuji  九州歯科大学, 歯学部, 教授 (60211546)

Co-Investigator(Kenkyū-buntansha) MASAKI CHIHIRO  九州歯科大学, 歯学部, 准教授 (60397940)
KONDO YUSUKE  九州歯科大学, 歯学部, 助教 (00611287)
MUKAIBO TARO  九州歯科大学, 歯学部, 助教 (50635117)
Co-Investigator(Renkei-kenkyūsha) TAMURA AKIKO  九州歯科大学, 歯学部附属病院, 医員 (30762067)
Project Period (FY) 2015-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords歯科補綴学一般 / 歯科インプラント / 物理刺激 / 細胞分化
Outline of Final Research Achievements

In this study, we tried to clarify osteocytic cilia related signaling by shutting out mechanical stimulation and to find out biomolecules concerning inhibitive control of bone resorption. IDG-SW3 cells were cultured and, taken into differentiating condition (Day0), fluorescent development of GFP, which is expressed in cooperation with Dmp1 expression and IDG-SW3 differentiation, was confirmed. Also, primary osteocytes were acquired from long bones of Dmp1-GFP transgenic mouse, and samples are being taken under analysis.

Report

(2 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (1 results)

All 2016

All Presentation (1 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Presentation] Risk management of replacing missing teeth with Implants2016

    • Author(s)
      RYUji HOSOKAWA
    • Organizer
      Asian Academy of Osseointegration
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2016-06-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2015-04-16   Modified: 2017-05-10  

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