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A study of crystal growth and its relation to bioactivity of calcium phosphate materials

Research Project

Project/Area Number 15K15720
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTohoku University

Principal Investigator

Suzuki Osamu  東北大学, 歯学研究科, 教授 (60374948)

Co-Investigator(Kenkyū-buntansha) 上家 潤一  麻布大学, 獣医学部, 准教授 (10400269)
鈴木 堅太郎  東北大学, 歯学研究科, 大学院非常勤講師 (10747554)
穴田 貴久  東北大学, 歯学研究科, 准教授 (30398466)
松井 有恒  東北大学, 大学病院, 医員 (60547264)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords生体材料 / 結晶相 / セラミックス / 生体活性 / 表面 / 水和
Outline of Final Research Achievements

The present study was designed to investigate as to whether calcium phosphate precipitation and its crystal phases affect its bioactivity of materials used for bone substitute materials. The materials, synthesized in batch or continuous preparations, were made through wet and dry mixing procedures and subjected for analyses by physical techniques, such as Raman spectroscopy, to indentify the crystal phases included. It was suggested that the activity of osteoblastic cells could be influenced by distinct crystals of octacalcium phosphates obtained in the continuous preparation.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (2 results)

  • [Journal Article] Dose-dependent enhancement of octacalcium phosphate biodegradation with gelatin matrix during bone regeneration in a rabbit tibial defect model2016

    • Author(s)
      K Saito, T Anada, Y Shiwaku, S Chiba, N Miyatake, K Suzuki, K Tsuchiya, O Suzuki
    • Journal Title

      RSC Adv

      Volume: 6 Issue: 69 Pages: 64165-64174

    • DOI

      10.1039/c6ra07602e

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] リン酸オクタカルシウム2015

    • Author(s)
      鈴木堅太郎,鈴木 治
    • Journal Title

      臨床雑誌 整形外科

      Volume: 66 Pages: 1192-1192

    • Related Report
      2015 Research-status Report
  • [Presentation] 骨芽細胞分化促進作用を有する生体内吸収性リン酸八カルシウム骨補填材の開発2016

    • Author(s)
      鈴木 治,穴田貴久
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] リン酸オクタカルシウムとハイドロキシアパタイトの炎症性細胞浸潤の比較2016

    • Author(s)
      塩飽由香利,平山聞一,穴田貴久,宮武尚央,土屋香織,中村雅典,高橋哲,鈴木治
    • Organizer
      日本バイオマテリアル学会東北地域講演会
    • Place of Presentation
      仙台
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] /Hydrolysis of hydroxyapatite precursors and its biological relevance in hard tissue formation/Dec 2, 2015/Sendai2015

    • Author(s)
      Suzuki O. Anada T, Kobayashi K, Shiwaku Y
    • Organizer
      French-Tohoku Frontier 2015
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] 東北大学大学院歯学研究科 顎口腔機能創建学分野HP

    • URL

      http://www.cfe.dent.tohoku.ac.jp

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東北大学大学院歯学研究科 顎口腔機能創建学分野HP

    • URL

      http://www.cfe.dent.tohoku.ac.jp/

    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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