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Development of novel metal allergy patch test resource using metal nanoballs

Research Project

Project/Area Number 15K15721
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

UO Motohiro  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (20242042)

Co-Investigator(Kenkyū-buntansha) 尾曲 大輔  日本大学, 歯学部, 助教 (10608699)
和田 敬広  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (10632317)
本郷 敏雄  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (60142444)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords金属アレルギー / パッチテスト / ナノ材料
Outline of Final Research Achievements

In this study, metal nanoballs were applied as the resource of metal allergy patch test and the metal ion release and permeation into skin were estimated.
Ni and other metal nanoballs were dispersed in the mildly acidic solution and the enough ion release through the dialysis membrane was confirmed. Also, continuous ion permeation into skin with same method was estimated with the synchrotron radiation X-ray fluorescence. The permeation occurred in lower concentration with time dependently compared to conventional patch test.
In conclusion, the metal nanoballs was suggested to be applicable as the resource of metal allergy patch test.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Journal Article] Copper accumulation in the sequestrum of medication-related osteonecrosis of the jaw2015

    • Author(s)
      Sugiyama T., Uo M., Mizoguchi T., Wada T., Omagari D, Komiyama K., Mori Y.
    • Journal Title

      Bone Reports

      Volume: 3 Pages: 40-47

    • DOI

      10.1016/j.bonr.2015.08.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 合成ケイ酸カルシウムセメントの圧縮強度と操作性向上に関する研究2017

    • Author(s)
      姜 東勲,和田敬広,宇尾基弘,興地隆史
    • Organizer
      第70 回日本歯科理工学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] イオン徐放性S-PRG フィラー含有根面う蝕修復用セメントの機械的強度と微細構造解析2017

    • Author(s)
      清水畑誠,猪越正直,和田敬広,高橋礼奈,宇尾基弘,水口俊介
    • Organizer
      第70 回日本歯科理工学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of a quantitative method of residual substances in the autopolymerizing acrylic resin2016

    • Author(s)
      Toshio Hongo, TakahiroWada, Motohiro Uo
    • Organizer
      International Dental Materials Congress 2016
    • Place of Presentation
      バリ(インドネシア)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of mechanical properties of an experimental synthetic tricalcium silicate cement.2016

    • Author(s)
      Donghoon Kang, Takahiro Wada, Motohiro Uo, Takashi Okiji
    • Organizer
      The 18th Joint Scientific Meeting of Korean Academy of Conservative Dentistry - Japanese Society of Conservative Dentistry
    • Place of Presentation
      ソウル(大韓民国)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 微小部XRF· XAFS の生物試料分析への応用とBL-15 への期待2015

    • Author(s)
      和田敬広, 宇尾基弘
    • Organizer
      PF 研究会
    • Place of Presentation
      高エネルギー加速器研究機構(茨城県つくば市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] μ-XAFS Investigation of a Real μ-Gas Sensor to Reveal the Origin of Methane Selectivity Degradation2015

    • Author(s)
      T. Wada, N. Murata, H. Uehara, T. Suzuki, Y. Niwa, H. Nitani, M. Uo, K. Asakura
    • Organizer
      XAFS16
    • Place of Presentation
      Karlsruhe (Germany)
    • Year and Date
      2015-08-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Detection and chemical state analysis of trace metallic elements in oral mucosal lesions using SR-XRF, PIXE, and XAFS2015

    • Author(s)
      T. Sugiyama, M. Uo, T. Wada, D. Omagari, K. Komiyama, Y. Mori
    • Organizer
      XAFS16
    • Place of Presentation
      Karlsruhe (Germany)
    • Year and Date
      2015-08-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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