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Development of functional nano-particle based bioadhesive

Research Project

Project/Area Number 15K15723
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionOkayama University

Principal Investigator

Matsumoto Takuya  岡山大学, 医歯薬学総合研究科, 教授 (40324793)

Co-Investigator(Kenkyū-buntansha) 岡田 正弘  岡山大学, 医歯薬学総合研究科, 准教授 (70416220)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords生体材料 / 組織接着 / 無機パーティクル / 生体組織接着 / バイオマテリアル
Outline of Final Research Achievements

In this study, we developed a novel biological tissue adhesive based on nanoapatite synthesized in various shapes as base materials. Here we showed their possibility for bioadhesives. Mechanical properties of this adhesion was carried out, and the mechanism from a histological point of view was also investigated. As a result, uptake of concentrated collagen fibers into the apatite pores was observed, and the possibility of water transfer as an adhesion mechanism was also suggested.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (4 results) (of which Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Biocompatible nanostructured solid adhesives for biological soft tissues2017

    • Author(s)
      M. Okada, A. Nakai, E. Hara, T. Taguchi, T. Nakano, T. Matsumoto
    • Journal Title

      Acta Biomaterialia

      Volume: 57 Pages: 404-413

    • DOI

      10.1016/j.actbio.2017.05.014

    • NAID

      120006635193

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Mg and Sr onto the crystallinity of bones evaluated through Raman spectroscopy and laser ablation-ICPMS analysis2017

    • Author(s)
      Yu-ki Tanaka, Nobuyuki Yajima, Masahiro Okada, Takuya Matsumoto, Yuhsuke Higuchi, Yoshiharu Itoh, Hideyuki Yamato, Takafumi Hirata
    • Journal Title

      Analyst

      Volume: 142 Issue: 22 Pages: 4265-4278

    • DOI

      10.1039/c7an00734e

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adsorption and desorption behaviors of cetylpyridinium chloride on hydroxyapatite nanoparticles with different morphologies.2016

    • Author(s)
      Okada M, Hiramatsu D, Okihara T, Matsumoto T.
    • Journal Title

      Dent Mater J

      Volume: 35 Pages: 651-658

    • NAID

      130005254707

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Fabrication Methods of Hydroxyapatite Nanocomposites2016

    • Author(s)
      Okada M, Matsumoto T
    • Journal Title

      Nano Biomed

      Volume: 8 Pages: 15-26

    • NAID

      130005249736

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Adsorption and desorption behaviors of cetylpyridinium chloride on hydroxyapatite nanoparticles with different morphologies2016

    • Author(s)
      Hiramatsu D, Okada M, Okita H, Matsumoto T
    • Journal Title

      Dent Mater J

      Volume: ##

    • NAID

      130005254707

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 異なるイオンを置換したアパタイトの水和状態に関する検討2017

    • Author(s)
      小林大介、岡田正弘、松本卓也
    • Organizer
      日本歯科理工学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 置換イオン含有量の異なるアパタイトの水和構造の評価2017

    • Author(s)
      岡田正弘、田中賢、松本卓也
    • Organizer
      日本バイオマテリアル学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ハイドロキシアパタイトを用いた生体組織用接着剤の開発2016

    • Author(s)
      中井 彰
    • Organizer
      第4回日本バイオマテリアル学会中四国シンポジウム
    • Place of Presentation
      徳島
    • Year and Date
      2016-02-16
    • Related Report
      2015 Research-status Report
  • [Presentation] もの作りの観点で骨発生をみなおす2016

    • Author(s)
      松本卓也
    • Organizer
      IBBセミナー 東京医科歯科大学
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
    • Invited
  • [Patent(Industrial Property Rights)] 生体組織接着剤2017

    • Inventor(s)
      松本卓也、岡田正弘
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-188999
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2021-03-11  

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