Immunomodulatory effect of human dental pulp cells in autoimmune disease
| Project/Area Number |
15K15724
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
Honda Masaki 愛知学院大学, 歯学部, 教授 (70361623)
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| Co-Investigator(Renkei-kenkyūsha) |
Watanabe Nobukazu 東京大学, 医科学研究・FACSコアラボラトリー, 特任准教授 (10334278)
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| Research Collaborator |
Saito Kouichi アイル再生医療研究センター
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯髄幹細胞 / 自己免疫疾患 / 免疫寛容能 / 制御性T細胞 / ヘルパーT細胞 / リンパ球 / １型糖尿病 / Th17細胞 / サイトカイン / 細胞傷害性T細胞 / ヒト歯髄幹細胞 |
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| Outline of Final Research Achievements |
Mesenchymal stromal cells (MSCs) are multipotent progenitors that can be isolated from the connective tissues of most organs. In addition, they exert powerful immunomodulatory effects, including inhibition of proliferation and function of Th17 cells and promotion of Treg differentiation. The objective of this study was to identify immune cell populations that participate in the mechanisms to prevent and reverse type 1 diabetes in the Non-Obese Diabetic (NOD) mouse strain. Co-culture experiments using human dental pulp cells and spleen cells from NOD. These results showed that Treg cells increased the frequency and numbers of interleukin-10 in vitro. The expansion of these cells was a consequence of the proliferation. In contrast, the number of Th17 cells was deceased by co-culture. This study showed that human dental pulp stem cells have a potential to regulate the differentiation into regulatory T cells and Helper T cells.
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Report
(3 results)
Research Products
(40 results)
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[Journal Article] Transplantation of mature adipocyte-derived dedifferentiated fat cells into three-wall defects in the rat periodontium induces tissue regeneration2017
Author(s)
Daigo Suzuki, Daisuke Akita, Niina Tsurumachi, Koichiro Kano, Katsuyuki Yamanaka, Tadashi Kaneko, Eisuke Kawano, Shinya Iguchi, Taku Toriumi, Yoshinori Arai, Taro Matsumoto, Shuichi Sato, Masaki Honda
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Journal Title
Journal of Oral Science
Volume: in press
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effect of local bone marrow stromal cell administration on ligature-induced periodontitis in mice2017
Author(s)
Shinya Iguchi, Daigo Suzuki, Eisuke Kawano, Takayuki Mashimo, Mikihito Kajiya, Taku Toriumi, Toshihisa Kawai, Hidemi Kurihara, Keitaro Isokawa, Shuichi Sato, Masaki Honda
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Journal Title
Journal of Oral Sciences
Volume: in press
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Use of rat mature adipocyte-derived dedifferentiated fat cells as a cell source for periodontal tissue regeneration.2016
Author(s)
Akita D, Kano K, Saito-Tamura Y, Mashimo T, Sato-Shionome M, Tsurumachi N, Yamanaka K, Kaneko T, Toriumi T, Arai Y, Tsukimura N, Matsumoto T, Ishigami T, Isokawa K, Honda M
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Journal Title
Frontier Physiology
Volume: 7
Pages: 50-50
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Small buccal fat pad cells have high osteogenic differentiateon potential.2016
Author(s)
Tsurumachi N, Akita D, Kano K, Matsumoto T, Toriumi T, Kazama T, Oki Y, Tamura Y,Tonogi M, Isokawa K, Shimizu N, Honda M
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Journal Title
Tissue Engineering Part C: Methods
Volume: 22
Issue: 3
Pages: 250-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Use of Rat Mature Adipocyte-Derived Deffirentiated Fat Cells as a Cell Source for Periodontal Tissue Regeneration.2016
Author(s)
Akita D, Kano K, Saito-Tamura Y, Mashimo T, Sato-Shionome M, Tsurumachi N, Yamanaka K, Kaneko T Toriumi T, Arai Y, Tsukimura N, Matsumoto T, Ishigami T, Iisokawa K, Honda M.
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Journal Title
Front Physiol
Volume: 印刷中
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Small Buccal Fat Pad Cells Have High Osteogenic Differentiation potential.2016
Author(s)
Tsurumachi N, Akita D, Kano K, Matsumoto T, Toriumi T, Kazama T, oki Y, Tamura Y, Tonoji M, Iisokawa K, Shimizu N, Honda M.
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Journal Title
Tissue Eng Part C Methods
Volume: 22(3)
Pages: 250-9
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Characterization of mesenchymal progenitor cells in the crown and root pulp of primary teeth.2015
Author(s)
Toriumi T, Takayama N, Murakami M, Sato M, Yuguchi M, Yamazaki Y, Eto K, Otsu M, Nakauchi H, Shirakawa T, Isokawa K, Honda MJ.
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Journal Title
Biomed Res
Volume: 36(1)
Pages: 31-45
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Use of BMSCs prevents alveolar bone resorption on experimental periodontitis2016
Author(s)
Iguchi S, Kawano E, Suzuki D, Tsurumachi N, Kajiya M, Toriumi T, Isokawa K, Arai Y, Fukuda T, Fujisaki Y, Sugano N, Sato S, Honda M
Organizer
The 102nd Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology and Japanese academy of Clinical Periodontology
Place of Presentation
San Diego Convention Center (San Diego, CA, USA)
Year and Date
2016-09-10
Related Report
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[Presentation] Dedifferentiated fat cells for tissue engineering in rat periodontal defects2016
Author(s)
Suzuki D, Iguchi S, Kawano E, Tsurumachi N, Toriumi T, Isokawa K, Arai Y, Sakai A, Ooshio K, Sugano N, Sato S, Honda M
Organizer
The 102nd Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology and Japanese academy of Clinical Periodontology
Place of Presentation
San Diego Convention Center (San Diego, CA, USA)
Year and Date
2016-09-10
Related Report
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