Role of M2 macrophages in reparative dentin formation and development of new endodontic regerative treatment
| Project/Area Number |
15K15725
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
二宮 禎 松本歯科大学, 総合歯科医学研究所, 講師 (00360222)
細矢 明宏 松本歯科大学, 歯学部, 講師 (70350824)
堀部 寛治 松本歯科大学, 歯学部, 助教 (70733509)
雪田 聡 静岡大学, 教育学部, 准教授 (80401214)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | M2マクロファージ / 歯髄 / 修復象牙質 / Wntシグナル / 免疫組織化学 / 歯髄組織 |
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| Outline of Final Research Achievements |
We examined immunohisotochmical localization of Wnt signaling molecules in the process of reparative dentin formation after cavity preparation in order to clarify a role of M2 macrophages in the odontoblastic differentiation of pulp cells. At 3 days after cavity preparation, macrophages showed immunoreactivity for Wnt10a and GPR177. At 7 days, localization of b-catenin is seen in nucleus of odontoblasts contacting reparative dentin. These results indicate that canonical Wnt signal plays an important role in reparative dentin formation. Reagents activating canonical Wnt signal might be usuful for new endodontic treatment.
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Report
(3 results)
Research Products
(2 results)
