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Role of M2 macrophages in reparative dentin formation and development of new endodontic regerative treatment

Research Project

Project/Area Number 15K15725
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

NAKAMURA Hiroaki  松本歯科大学, 歯学部, 教授 (50227930)

Co-Investigator(Kenkyū-buntansha) 二宮 禎  松本歯科大学, 総合歯科医学研究所, 講師 (00360222)
細矢 明宏  松本歯科大学, 歯学部, 講師 (70350824)
堀部 寛治  松本歯科大学, 歯学部, 助教 (70733509)
雪田 聡  静岡大学, 教育学部, 准教授 (80401214)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsM2マクロファージ / 歯髄 / 修復象牙質 / Wntシグナル / 免疫組織化学 / 歯髄組織
Outline of Final Research Achievements

We examined immunohisotochmical localization of Wnt signaling molecules in the process of reparative dentin formation after cavity preparation in order to clarify a role of M2 macrophages in the odontoblastic differentiation of pulp cells. At 3 days after cavity preparation, macrophages showed immunoreactivity for Wnt10a and GPR177. At 7 days, localization of b-catenin is seen in nucleus of odontoblasts contacting reparative dentin. These results indicate that canonical Wnt signal plays an important role in reparative dentin formation. Reagents activating canonical Wnt signal might be usuful for new endodontic treatment.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Localization of REKM-b/FIZZ2 is associated with cementum formation.2017

    • Author(s)
      Hosoya A, Takahama A , Nakamura H
    • Journal Title

      The Anatomical Record

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 象牙芽細胞分化におけるポリコーム群タンパク質Bmi1の機能2016

    • Author(s)
      細矢明宏、吉羽邦彦、吉羽永子、鷲尾絢子、諸冨孝彦、北村知昭、山本昭夫、中村浩彰
    • Organizer
      日本歯科保存学会秋期学術集会
    • Place of Presentation
      キッセイ文化ホール(松本市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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