| Project/Area Number |
15K15726
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
間石 奈湖 北海道大学, 遺伝子病制御研究所, 助教 (00632423)
秋山 廣輔 北海道大学, 遺伝子病制御研究所, 客員研究員 (10609100)
大賀 則孝 北海道大学, 歯学研究科, 助教 (40548202)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | がん / 腫瘍血管 / miRNA |
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| Outline of Final Research Achievements |
In this study, we have tried to identify miRNAs which are involved in tumor vessel abnormality and to evaluate their roles in tumor invasion and metastasis, in order to develop novel cancer diagnostics and therapy. Endothelial cells were treated by cancer-derived exosome. Several miRNAs were upregulated and their function were analyzed. Using miRNA database, the target gene of these miRNAs were picked up and the involvement of these target molecule in tumor vessel abnormality were addressed.
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