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Evaluation of the therapeutic benefits of anti-inflammatory M2 macrophage inducer for distraction osteogenesis

Research Project

Project/Area Number 15K15736
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionThe University of Tokushima (2016)
Nagoya University (2015)

Principal Investigator

YAMAMOTO Akihito  徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (50244083)

Research Collaborator KANO Fumiya  名古屋大学, 大学院医学系研究科口腔外科, 大学院生
ISHIKAWA Jun  名古屋大学, 大学院医学系研究科口腔外科, 大学院生
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords骨延長 / マクロファージ / 炎症 / 骨延長術 / 治療期間 / 再生 / 再生医学 / 血管再生 / 骨芽細胞 / 破骨細胞 / 間葉系幹細胞
Outline of Final Research Achievements

Distraction osteogenesis (DO) successfully induces large-scale skeletal tissue regeneration, but it involves an undesirably long treatment period. A high-speed DO mouse model (H-DO) failed to generate new bone callus in the distraction gap. In this study, we showed that H-DO induced pro-inflammatory reaction in the gap. Importantly, we found that administration of anti-inflammatory M2 macrophage inducer, monocyte chemoattractant protein-1 (MCP-1) and the secreted ectodomain of sialic acid-binding Ig-like lectin-9 (ED-Siglec-9), restored callus formation in the H-DO- gap.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] 脱落乳歯歯髄幹細胞由来の 無血清培養上清を用いた再生医療2016

    • Author(s)
      山本朗仁
    • Organizer
      第23回日本歯科医学会総会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-10-21
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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