Evaluation of the therapeutic benefits of anti-inflammatory M2 macrophage inducer for distraction osteogenesis
| Project/Area Number |
15K15736
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | The University of Tokushima (2016)
Nagoya University (2015) |
|---|
Principal Investigator |
YAMAMOTO Akihito 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (50244083)
|
|---|
| Research Collaborator |
KANO Fumiya 名古屋大学, 大学院医学系研究科口腔外科, 大学院生
ISHIKAWA Jun 名古屋大学, 大学院医学系研究科口腔外科, 大学院生
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 骨延長 / マクロファージ / 炎症 / 骨延長術 / 治療期間 / 再生 / 再生医学 / 血管再生 / 骨芽細胞 / 破骨細胞 / 間葉系幹細胞 |
|---|
| Outline of Final Research Achievements |
Distraction osteogenesis (DO) successfully induces large-scale skeletal tissue regeneration, but it involves an undesirably long treatment period. A high-speed DO mouse model (H-DO) failed to generate new bone callus in the distraction gap. In this study, we showed that H-DO induced pro-inflammatory reaction in the gap. Importantly, we found that administration of anti-inflammatory M2 macrophage inducer, monocyte chemoattractant protein-1 (MCP-1) and the secreted ectodomain of sialic acid-binding Ig-like lectin-9 (ED-Siglec-9), restored callus formation in the H-DO- gap.
|
Report
(3 results)
Research Products
(1 results)
