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Development of a novel treatment for oral mucositis associated with chemoradiotherapy for head and neck cancers using LED light

Research Project

Project/Area Number 15K15738
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionKobe University

Principal Investigator

KOMORI TAKAHIDE  神戸大学, 医学研究科, 教授 (50251294)

Co-Investigator(Kenkyū-buntansha) 鈴木 泰明  神戸大学, 医学部附属病院, 講師 (10397812)
南川 勉  神戸大学, 医学部附属病院, 講師 (10397804)
木本 明  神戸大学, 医学部附属病院, 特定助教 (30597167)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsLED / LLLT / 口腔粘膜炎
Outline of Final Research Achievements

Overseas, treatment of oral mucositis associated with anticancer drugs and radiation treatment in head and neck cancers has been undertaken using laser light called "Low reactive Level Laser Treatment (LLLT)". However, in our country, LLLT is not used at all in clinical practice as well as research. In recent years, LLLT including other light sources such as LEDs has come to be called "Low reactive Level Light Treatment". Therefore, our research has the possibility to realize treatment of oral mucositis using LED light which is cheaper and easier than laser if we can find the effectiveness of LED.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 7 results,  Open Access: 7 results) Presentation (4 results) (of which Int'l Joint Research: 1 results) Book (3 results)

  • [Journal Article] Intensity and duration of neutropenia relates to the development of oral mucositis but not odontogenic infection during chemotherapy for hematological malignancy.2017

    • Author(s)
      Kishimoto M, Akashi M, Tsuji K, Kusumoto J, Furudoi S, Shibuya Y, Inui Y, Yakushijin K, Kawamoto S, Okamura A, Matsuoka H, Komori T
    • Journal Title

      PLoS One.

      Volume: 12

    • NAID

      120006373763

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A retrospective evaluation of partial glossectomy for early tongue cancer using a carbon dioxide laser.2017

    • Author(s)
      Kimoto A, Suzuki H, Yamashita J, Takeuchi J, Matsumoto K, Enomoto Y, Komori T.
    • Journal Title

      Photomed Laser Surg.

      Volume: 35 Pages: 479-483

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The maximum standardized uptake value increment calculated by dual-time-point F-fluorodeoxyglucose positron emission tomography predicts survival in patients with oral tongue squamous cell carcinoma.2017

    • Author(s)
      Yonezawa N,Minamikawa T,Kitajima K,Takahashi Y, Sasaki R,Nibu K, Komori T.
    • Journal Title

      NAGOYA JOURNAL OF MEDICAL SCIENCE

      Volume: 79 Pages: 189-198

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Retrospective study of treatment outcomes after postoperative chemoradiotherapy in Japanese oral squamous cell carcinoma patients with risk factors of recurrence.2017

    • Author(s)
      Hasegawa T, Yanamoto S, Otsuru M, Yamada SI, Minamikawa T, Shigeta T, Naruse T, Suzuki T, Sasaki M, Ota Y, Umeda M, Komori T.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol.

      Volume: 127 Pages: 524-530

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of perioperative oral care on prevention of postoperative pneumonia associated with esophageal cancer surgery.2017

    • Author(s)
      Soutome S,Yanamoto S,Funahara M,Hasegawa T,Komori T,Yamada S, Kurita H,Yamauchi C,Shibuya Y,Kojima Y,Nakahara H,Oho T,Umeda M.Effect of perioperative oral care on prevention of postoperative pneumonia associated with esophageal cancer surgery.
    • Journal Title

      Medicine

      Volume: 33 Pages: 1-5

    • NAID

      120006373792

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 頭頸部癌患者における化学放射線療法による口腔粘膜炎の重症度を予測する因子.2017

    • Author(s)
      岸本恵美,古土井春吾,岩田英治,藤林淳子,楠元順哉,明石昌也,古森孝英.
    • Journal Title

      日本口腔感染症学会雑誌

      Volume: 24 Pages: 9-13

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 【最近の歯科におけるレーザーの応用】口腔外科領域におけるレーザーの応用.2016

    • Author(s)
      古森孝英,榎本由依,北山美登里,小守紗也華,松本耕祐,木本 明,竹内純一郎,鈴木泰明.
    • Journal Title

      日本レーザー医学会誌

      Volume: 37 Pages: 52-57

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 赤色LED光による口腔扁平上皮癌細胞株の遊走能促進にはIL-8が関与する.2017

    • Author(s)
      1.松尾健司,鈴木泰明,八谷奈苗,山下淳也,榎本由依,松本耕祐,北山美登里,重岡 学,古森孝英.
    • Organizer
      第30回レーザー医学会 関西地方会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔扁平上皮癌細胞に与えるLED光照射の影響.2017

    • Author(s)
      2.松尾健司,鈴木泰明,八谷奈苗,山下淳也,榎本由依,筧 康正,松本耕祐,北山美登里、重岡 学,古森孝英.
    • Organizer
      第29回日本レーザー歯学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔扁平上皮癌細胞に及ぼすLED照射の影響-安全な臨床応用を目指して-.2017

    • Author(s)
      3.松尾健司,鈴木泰明,榎本由依,松本耕祐,北山美登里、重岡 学,古森孝英.
    • Organizer
      第62回(公社)日本口腔外科学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] EFFECTS OF RED LIGHT-EMITTING DIODE IRRADIATION ON THE PROLIFERATION AND DIFFERENTIATION OF PREOSTEOBLASTIC MC3T3-E1 CELLS2015

    • Author(s)
      Hiroaki Suzuki, Tomoko Asai, Yui Enomoto, Midori Kitayama, Kousuke Matsumoto, Akira Kimoto, Manabu Shigeoka, Daichi Chikazu, Takahide Komori
    • Organizer
      22nd International Conference on Oral and Maxillofacial Surgery
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2015-10-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 「改訂版 口腔ケア基礎知識」. 日本口腔ケア学会, 編. 糖尿病患者の口腔ケア. 201-202頁.2017

    • Author(s)
      古森孝英
    • Total Pages
      376
    • Publisher
      永末書店
    • Related Report
      2017 Annual Research Report
  • [Book] 「改訂版 口腔ケア基礎知識」. 日本口腔ケア学会, 編. 心疾患患者の口腔ケア. 203-204頁.2017

    • Author(s)
      古森孝英
    • Total Pages
      376
    • Publisher
      永末書店
    • Related Report
      2017 Annual Research Report
  • [Book] 「地域包括ケアと口腔ケア」. 2-3-1心疾患について2) 服用薬剤が原因となる口腔症状. 49-51頁.2017

    • Author(s)
      古森孝英
    • Total Pages
      192
    • Publisher
      口腔保健協会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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