Explore for master regulator of EMT in oral cancer
Project/Area Number |
15K15740
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | The University of Tokushima |
Principal Investigator |
TSUNEMATSU Takaaki 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (70726752)
|
Co-Investigator(Kenkyū-buntansha) |
工藤 保誠 徳島大学, 大学院医歯薬学研究部(歯学系), 准教授 (50314753)
|
Co-Investigator(Renkei-kenkyūsha) |
ISHIMARU Naozumi 徳島大学, 大学院医歯薬学研究部, 教授 (60314879)
ARAKAKI Rieko 徳島大学, 大学院医歯薬学研究部, 准教授 (00193061)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 口腔扁平上皮癌 / EMT / 口腔癌 / 上皮間葉移行 |
Outline of Final Research Achievements |
It is known that Epithelial Mesenchymal Transition, EMT is important step in cancer invasion and metastasis. Interestingly, there are spindle cell carcinoma with EMT phenotype known as the subtype of oral squamous cell carcinoma . In this study, we tried to explore the master regulator of EMT by using spindle cell carcinoma cell lines which we previously established. We could not identify the master regulator of EMT but established the spindle cell carcinoma cell line with reporter gene. In future, we try to identify the master regulator of EMT by using this reporter cell line.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Clear cell odontogenic carcinoma: establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene.2017
Author(s)
Kujiraoka S, Tsunematsu T, Sato Y, Yoshida M, Ishikawa A, Tohyama R, Tanaka M, Kobayashi Y, Kondo T, Ushio A, Otsuka K, Kurosawa M, Saito M, Yamada A, Arakaki R, Nagai H, Nikai H, Takeuchi K, Nagao T, Miyamoto Y, Ishimaru N, Kudo Y.
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Journal Title
Oral Oncology
Volume: 印刷中
Pages: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Ameloblastin induces tumor suppressive phenotype and enhances chemosensitivity to doxorubicin via Src-Stat3 inactivation in osteosarcoma.2016
Author(s)
Ando T, Kudo Y, Iizuka S, Tsunematsu T, Umehara H, Shrestha M, Matsuo T, Kubo T, Shimose S, Arihiro K, Ogawa I, Ochi M, Takata T.
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Journal Title
Scientific Reports
Volume: 7
Pages: 40187
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Human odontogenic epithelial cells derived from epithelial rests of Malassez possess stem cell properties.2016
Author(s)
Tsunematsu T, Fujiwara N, Yoshida M, Takayama Y, Kujiraoka S, Qi G, Kitagawa M, Kondo T, Yamada A, Arakaki R, Miyauchi M, Ogawa I, Abiko Y, Nikawa H, Murakami S, Takata T, Ishimaru N, Kudo Y.
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Journal Title
Laboratory Investigation
Volume: 96(10)
Pages: 1063-1075
DOI
Related Report
Peer Reviewed
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[Journal Article] PARP6 acts as a tumor suppressor via downregulating Survivin expression in colorectal cancer.2016
Author(s)
Qi G, Kudo Y, Tang B, Liu T, Jin S, Liu J, Zuo X, Mi S, Shao W, Ma X, Tsunematsu T, Ishimaru N, Zeng S, Tatsuka M, Shimamoto F.
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Journal Title
Oncotarget
Volume: 7(14)
Pages: 18812-18824
DOI
Related Report
Peer Reviewed
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[Journal Article] PARP6 inhibits cell growth and survival via inhibiting the Survivin expression in colorectal cancer2016
Author(s)
Qi, G., Kudo, Y., Tang, B., Liu, T., Jin, S., Liu, J., Zuo, X., Mi, S., Shao, W., Ma, X., Tsunematsu, T., Ishimaru, N., Zeng, S., Tatsuka, M., Shimamoto, F.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Molecular mechanism of metal allergy2016
Author(s)
Saito, M., Arakaki, R., Yamada, A., Tsunematsu, T., Kudo, Y., Ishimaru, N.
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Journal Title
Int. J. Mol. Sci
Volume: 17(2)
Pages: E202
DOI
Related Report
Peer Reviewed
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[Journal Article] MicroRNA-203 Suppresses Invasion and Epithelial-mesenchymal Transition Induction via Targeting NUAK1 and SNAI2 in Head and Neck Cancer2016
Author(s)
Obayashi, M., Yoshida, M., Tsunematsu, T., Ogawa, I., Sasahira, T., Kuniyasu, H., Imoto, I., Abiko, Y., Xu, D., Fukunaga, S., Tahara, H., Kudo, Y., Nagao, T., Takata, T.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Acceleration of Tumor Growth due to Dysfunction in M1 Macrophages and Enhanced Angiogenesis in an Animal Model of Autoimmune Disease2016
Author(s)
Kondo, T., Tsunematsu, T., Yamada, A., Arakaki, R., Saito, M., Oysuka, K., Kujiraoka, S., Ushio, A., Kurosawa, M., Kudo, Y., Ishimaru, N.
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Journal Title
Lab. Invest
Volume: 96(4)
Pages: 468-480
DOI
Related Report
Peer Reviewed
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[Journal Article] A role of regulatory T cell in the pathogenesis of IBD2016
Author(s)
Yamada, A., Arakaki, R., Saito, M., Tsunematsu, T., Kudo, Y., Ishimaru, N.
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Journal Title
World J. Gastroenterol
Volume: 22(7)
Pages: 2195-2205
DOI
Related Report
Peer Reviewed
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[Journal Article] Impaired Expansion of Regulatory T Cells in A Neonatal Thymectomy-Induced Autoimmune Mouse Model.2015
Author(s)
Yamada, A., Arakaki, R., Tsunematsu, T., Kudo, Y., Hayashi, Y., Ishimaru, N.
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Journal Title
Am. J. Pathol
Volume: 185(11)
Pages: 2886-2897
DOI
Related Report
Peer Reviewed
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